PRX-14040

PRX-14040
Clinical data
Other names	PRX14040
Drug class	Dopamine reuptake inhibitor; Pro-motivational agent
Identifiers
	IUPAC name 5-(2-(1-(3,4-dichlorophenyl)cyclobutyl)-2-hydroxyethyl)-2-oxa-5-azoniabicyclo[2.2.1]heptane chloride;
PubChem CID	117903522;
Chemical and physical data
Formula	C17H22Cl3NO2
Molar mass	378.72 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(C1)(C2=CC(=C(C=C2)Cl)Cl)C(C[NH+]3CC4CC3CO4)O.[Cl-];
	InChI InChI=1S/C17H21Cl2NO2.ClH/c18-14-3-2-11(6-15(14)19)17(4-1-5-17)16(21)9-20-8-13-7-12(20)10-22-13;/h2-3,6,12-13,16,21H,1,4-5,7-10H2;1H; Key:QAHXUHUHCQYFHC-UHFFFAOYSA-N;

PRX-14040 is a selective dopamine reuptake inhibitor that was developed by Prexa Pharmaceuticals.^[1]^[2]^[3] It has 28-fold selectivity for the dopamine transporter over the norepinephrine transporter.^[2] Similarly to various other dopamine reuptake inhibitors, the drug has been found to reverse motivational deficits induced by the dopamine depleting agent tetrabenazine in animals.^[1]^[2]

References

^ ^a ^b Salamone JD, Correa M, Ferrigno S, Yang JH, Rotolo RA, Presby RE (October 2018). "The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation". Pharmacol Rev. 70 (4): 747–762. doi:10.1124/pr.117.015107. PMC 6169368. PMID 30209181.
^ ^a ^b ^c Desibhatla, Mukund (16 June 2021). "The Development and Evaluation of Novel DA Transport Inhibitors and their Effects on Effort-Related Motivation: A Review". Honors Scholar Theses. Retrieved 10 August 2024.
^ Yohn SE, Gogoj A, Haque A, Lopez-Cruz L, Haley A, Huxley P, Baskin P, Correa M, Salamone JD (September 2016). "Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040". Pharmacol Biochem Behav. 148: 84–91. doi:10.1016/j.pbb.2016.06.004. PMID 27296079.

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