Lafadofensine

Lafadofensine
Clinical data
Drug class	Serotonin–norepinephrine–dopamine reuptake inhibitor
Identifiers
	IUPAC name (3S)-N,N-bis(4-fluorophenyl)pyrrolidin-3-amine;
CAS Number	914989-90-5 ; 914989-91-6 (fumarate);
PubChem CID	15605612;
ChemSpider	13081085;
UNII	7HFV4D3KJL;
ChEMBL	ChEMBL5095070;
Chemical and physical data
Formula	C16H16F2N2
Molar mass	274.315 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CNC[C@H]1N(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F;
	InChI InChI=1S/C16H16F2N2/c17-12-1-5-14(6-2-12)20(16-9-10-19-11-16)15-7-3-13(18)4-8-15/h1-8,16,19H,9-11H2/t16-/m0/s1; Key:ZKEVVJGPWXTETN-INIZCTEOSA-N;

Lafadofensine (INNTooltip International Nonproprietary Name), also known as (3S)-N,N-bis(4-fluorophenyl)pyrrolidin-3-amine, is a drug described as an antidepressant which has not been marketed at this time.^[1]^[2]^[3] It is said to act as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).^[1] The drug was first described by 2010^[4] and its INNTooltip International Nonproprietary Name was proposed by 2021.^[5]

References

^ ^a ^b World Health Organization (2024). "Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances, 2024" (PDF). World Health Organization. p. 102. Retrieved 21 October 2024. -fensine norepinephrine, serotonin, dopamine reuptake inhibitors brasofensine (76), diclofensine (44), lafadofensine (126), liafensine (109), nomifensine (24), perafensine (44), tesofensine (89)
^ "LAFADOFENSINE". Inxight Drugs. Retrieved 21 October 2024.
^ "Lafadofensine". PubChem. Retrieved 21 October 2024.
^ "N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors". Google Patents. 10 June 2010. Retrieved 21 October 2024.
^ https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf

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[WHO2024-1] World Health Organization (2024). "Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances, 2024" (PDF). World Health Organization. p. 102. Retrieved 21 October 2024. -fensine norepinephrine, serotonin, dopamine reuptake inhibitors brasofensine (76), diclofensine (44), lafadofensine (126), liafensine (109), nomifensine (24), perafensine (44), tesofensine (89)

[InxightDrugs-2] "LAFADOFENSINE". Inxight Drugs. Retrieved 21 October 2024.

[PubChem-3] "Lafadofensine". PubChem. Retrieved 21 October 2024.

[AU2006244851B2-4] "N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors". Google Patents. 10 June 2010. Retrieved 21 October 2024.

[WHO2021-5] ttps://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf

[1]

[2]

[3]

[4]

[5]

See also

References