User talk:Gmk625/sandbox

Join my sandbox!

https://en.wikipedia.org/wiki/User:Gmk625/sandbox

Okay group, try this and let me know if it worked... Trying to figure this out!

@Sjq94: @Blaketd: @Kny1216: @KatieWilhelmus:

Gmk625 (talk) 19:24, 2 November 2016 (UTC)

Alexander Disease Review

Yes the article has appropriate and reliable sources. I checked a few sources and some pages were not found KatieWilhelmus (talk) 02:17, 8 November 2016 (UTC)Katie Wilhelmus

Topics to consider adding: -age of onset -mode of inheritance -ethnic/racial bias -explain symptoms in lay terms Gmk625 (talk) 02:36, 8 November 2016 (UTC)

I added to treatment since there was not a lot of information there to begin with: Hydrocephaly may been seen in younger patients and can be relieved with surgery or implanting a shunt to relieve pressure[17]. " KatieWilhelmus (talk) 19:52, 15 November 2016 (UTC)KatieWilhelmusKatieWilhelmus (talk) 19:52, 15 November 2016 (UTC)

Modes of Inheritance and Symptoms

Alexander Disease is inherited in an autosomal dominant fashion by a heterozygous mutation in the GFAP gene on chromosome 17q21 . Autosomal Dominant means that the mutated gene is located on an autosome, which is not a sex chromosome, and is dominant to the normal allele. There are three types of Alexander disease, which are diagnosed by the difference in the age of onset . The three forms are infantile, juvenile and adult. The most common symptoms seen with Alexander disease are delays in physical, mental and behavioral development, seizures and an enlarged brain . Alexander disease is characterized by homogeneous eosinophilic masses called Rosenthal fibers. These fibers usually form throughout the surfaces of the brain and brain-stem . The Rosenthal fibers are located in astrocytes, which are cells that mimic blood vessels. These fibers produce a toxic a key feature of Alexander disease, which is demyelination of the brain . KatieWilhelmus (talk) 20:10, 15 November 2016 (UTC)KatieWilhelmus Kny1216 (talk) 05:31, 28 November 2016 (UTC)

Prevalence

Alexander disease is very rare. The estimated frequency of occurrence is about 1 in 1 million. To date, there have been over 550 cases of Alexander disease reported. However there are not any actual frequency of occurrence statistics published. There is no indication that Alexander disease has an ethnic, geographic, racial, or gender bias. At first, Alexander disease appeared to primarily occur in the early onset. However, it is now being seen in almost all age groups with approximately the same frequency. Kny1216 (talk) 05:40, 28 November 2016 (UTC)