Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 22:35, 10 November 2007 (UTC)
[edit]Proteins without matches (19)
[edit]Proteins with a High Potential Match (6)
[edit]Manual Inspection (Page not found) (14)
[edit]
Protein Status Grid - Date: 22:35, 10 November 2007 (UTC)
[edit]Vebose Log - Date: 22:35, 10 November 2007 (UTC)
[edit]- INFO: Beginning work on CBFB... {November 10, 2007 1:54:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CBFB image.jpg {November 10, 2007 1:55:11 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:55:23 PM PST}
- CREATED: Created new protein page: CBFB {November 10, 2007 1:55:31 PM PST}
- INFO: Beginning work on CCKAR... {November 10, 2007 1:55:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCKAR image.jpg {November 10, 2007 1:56:48 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:57:07 PM PST}
- CREATED: Created new protein page: CCKAR {November 10, 2007 1:57:17 PM PST}
- INFO: Beginning work on CD53... {November 10, 2007 1:58:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:59:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD53 molecule
| HGNCid = 1686
| Symbol = CD53
| AltSymbols =; MOX44; TSPAN25
| OMIM = 151525
| ECnumber =
| Homologene = 20152
| MGIid = 88341
| GeneAtlas_image1 = PBB_GE_CD53_203416_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 963
| Hs_Ensembl = ENSG00000143119
| Hs_RefseqProtein = NP_000551
| Hs_RefseqmRNA = NM_000560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 111217284
| Hs_GenLoc_end = 111244069
| Hs_Uniprot = P19397
| Mm_EntrezGene = 12508
| Mm_Ensembl = ENSMUSG00000040747
| Mm_RefseqmRNA = NM_007651
| Mm_RefseqProtein = NP_031677
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 106887989
| Mm_GenLoc_end = 106918108
| Mm_Uniprot = Q3TV80
}}
}}
'''CD53 molecule''', also known as '''CD53''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.<ref>{{cite web | title = Entrez Gene: CD53 CD53 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=963| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1-4 |year= 1991 |pmid= 1879540 |doi= }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDT1... {November 10, 2007 2:26:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:27:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chromatin licensing and DNA replication factor 1
| HGNCid = 24576
| Symbol = CDT1
| AltSymbols =; DUP; RIS2
| OMIM = 605525
| ECnumber =
| Homologene = 32650
| MGIid = 1914427
| GeneAtlas_image1 = PBB_GE_CDT1_209832_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005657 |text = replication fork}}
| Process = {{GNF_GO|id=GO:0000076 |text = DNA replication checkpoint}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007090 |text = regulation of S phase of mitotic cell cycle}} {{GNF_GO|id=GO:0030174 |text = regulation of DNA replication initiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 81620
| Hs_Ensembl = ENSG00000167513
| Hs_RefseqProtein = NP_112190
| Hs_RefseqmRNA = NM_030928
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 87397687
| Hs_GenLoc_end = 87403166
| Hs_Uniprot = Q9H211
| Mm_EntrezGene = 67177
| Mm_Ensembl = ENSMUSG00000006585
| Mm_RefseqmRNA = NM_026014
| Mm_RefseqProtein = NP_080290
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 125454116
| Mm_GenLoc_end = 125459644
| Mm_Uniprot = Q8R4E9
}}
}}
'''Chromatin licensing and DNA replication factor 1''', also known as '''CDT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Xouri G, Dimaki M, Bastiaens PI, Lygerou Z |title=Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing. |journal=Cell Cycle |volume=6 |issue= 13 |pages= 1549-52 |year= 2007 |pmid= 17598984 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CES1... {November 10, 2007 1:59:44 PM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 1:59:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:00:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CES1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mx1.
| PDB = {{PDB2|1mx1}}, {{PDB2|1mx5}}, {{PDB2|1mx9}}, {{PDB2|1ya4}}, {{PDB2|1ya8}}, {{PDB2|1yah}}, {{PDB2|1yaj}}, {{PDB2|2dqy}}, {{PDB2|2dqz}}, {{PDB2|2dr0}}, {{PDB2|2h7c}}, {{PDB2|2hrq}}, {{PDB2|2hrr}}
| Name = Carboxylesterase 1 (monocyte/macrophage serine esterase 1)
| HGNCid = 1863
| Symbol = CES1
| AltSymbols =; ACAT; CEH; CES2; HMSE; HMSE1; MGC117365; PCE-1; SES1; TGH
| OMIM = 114835
| ECnumber =
| Homologene = 35606
| MGIid = 2148202
| Function = {{GNF_GO|id=GO:0004091 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009636 |text = response to toxin}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1066
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001130190
| Hs_RefseqmRNA = XM_001130190
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 104158
| Mm_Ensembl = ENSMUSG00000056973
| Mm_RefseqmRNA = NM_053200
| Mm_RefseqProtein = NP_444430
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 96055196
| Mm_GenLoc_end = 96086907
| Mm_Uniprot = Q8VCT4
}}
}}
'''Carboxylesterase 1 (monocyte/macrophage serine esterase 1)''', also known as '''CES1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1066| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHGB... {November 10, 2007 2:00:27 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:01:02 PM PST}
- CREATED: Created new protein page: CHGB {November 10, 2007 2:01:11 PM PST}
- INFO: Beginning work on CHRNE... {November 10, 2007 2:01:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:02:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, epsilon
| HGNCid = 1966
| Symbol = CHRNE
| AltSymbols =; CMS2A; FCCMS; SCCMS; CMS1D; ACHRE; CMS1E
| OMIM = 100725
| ECnumber =
| Homologene = 60
| MGIid = 87894
| GeneAtlas_image1 = PBB_GE_CHRNE_207274_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0008324 |text = cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007271 |text = synaptic transmission, cholinergic}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1145
| Hs_Ensembl = ENSG00000108556
| Hs_RefseqProtein = NP_000071
| Hs_RefseqmRNA = NM_000080
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 4741840
| Hs_GenLoc_end = 4747148
| Hs_Uniprot = Q04844
| Mm_EntrezGene = 11448
| Mm_Ensembl = ENSMUSG00000014609
| Mm_RefseqmRNA = NM_009603
| Mm_RefseqProtein = NP_033733
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 70431078
| Mm_GenLoc_end = 70435389
| Mm_Uniprot = Q8K1N0
}}
}}
'''Cholinergic receptor, nicotinic, epsilon''', also known as '''CHRNE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The achetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.<ref>{{cite web | title = Entrez Gene: CHRNE cholinergic receptor, nicotinic, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1145| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hantaï D, Richard P, Koenig J, Eymard B |title=Congenital myasthenic syndromes. |journal=Curr. Opin. Neurol. |volume=17 |issue= 5 |pages= 539-51 |year= 2005 |pmid= 15367858 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DNAJA3... {November 10, 2007 2:16:32 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DNAJA3 image.jpg {November 10, 2007 2:18:01 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:18:15 PM PST}
- CREATED: Created new protein page: DNAJA3 {November 10, 2007 2:18:23 PM PST}
- INFO: Beginning work on ENTPD1... {November 10, 2007 1:57:17 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:58:49 PM PST}
- CREATED: Created new protein page: ENTPD1 {November 10, 2007 1:58:58 PM PST}
- INFO: Beginning work on GDF5... {November 10, 2007 2:07:53 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GDF5 image.jpg {November 10, 2007 2:08:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:08:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GDF5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1waq.
| PDB = {{PDB2|1waq}}, {{PDB2|2bhk}}
| Name = Growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)
| HGNCid = 4220
| Symbol = GDF5
| AltSymbols =; CDMP1; LAP4; SYNS2
| OMIM = 601146
| ECnumber =
| Homologene = 468
| MGIid = 95688
| GeneAtlas_image1 = PBB_GE_GDF5_206614_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0040007 |text = growth}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8200
| Hs_Ensembl = ENSG00000125965
| Hs_RefseqProtein = NP_000548
| Hs_RefseqmRNA = NM_000557
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 33484559
| Hs_GenLoc_end = 33505982
| Hs_Uniprot = P43026
| Mm_EntrezGene = 14563
| Mm_Ensembl = ENSMUSG00000038259
| Mm_RefseqmRNA = NM_008109
| Mm_RefseqProtein = NP_032135
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 155632468
| Mm_GenLoc_end = 155636808
| Mm_Uniprot = Q8BRW9
}}
}}
'''Growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)''', also known as '''GDF5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.<ref>{{cite web | title = Entrez Gene: GDF5 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8200| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reddi AH |title=Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix. |journal=Matrix Biol. |volume=14 |issue= 8 |pages= 599-606 |year= 1997 |pmid= 9057810 |doi= }}
*{{cite journal | author=Luyten FP |title=Cartilage-derived morphogenetic protein-1. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 11 |pages= 1241-4 |year= 1998 |pmid= 9451821 |doi= }}
*{{cite journal | author=Ducy P, Karsenty G |title=The family of bone morphogenetic proteins. |journal=Kidney Int. |volume=57 |issue= 6 |pages= 2207-14 |year= 2000 |pmid= 10844590 |doi= 10.1046/j.1523-1755.2000.00081.x }}
*{{cite journal | author=Faiyaz-Ul-Haque M, Ahmad W, Wahab A, ''et al.'' |title=Frameshift mutation in the cartilage-derived morphogenetic protein 1 (CDMP1) gene and severe acromesomelic chondrodysplasia resembling Grebe-type chondrodysplasia. |journal=Am. J. Med. Genet. |volume=111 |issue= 1 |pages= 31-7 |year= 2003 |pmid= 12124730 |doi= 10.1002/ajmg.10501 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IER3... {November 10, 2007 2:15:13 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:16:25 PM PST}
- CREATED: Created new protein page: IER3 {November 10, 2007 2:16:32 PM PST}
- INFO: Beginning work on IL1RL1... {November 10, 2007 2:18:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:19:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin 1 receptor-like 1
| HGNCid = 5998
| Symbol = IL1RL1
| AltSymbols =; T1; ST2; DER4; FIT-1; MGC32623; ST2L; ST2V
| OMIM = 601203
| ECnumber =
| Homologene = 2862
| MGIid = 98427
| GeneAtlas_image1 = PBB_GE_IL1RL1_207526_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0004908 |text = interleukin-1 receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9173
| Hs_Ensembl = ENSG00000115602
| Hs_RefseqProtein = NP_003847
| Hs_RefseqmRNA = NM_003856
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 102294394
| Hs_GenLoc_end = 102334929
| Hs_Uniprot = Q01638
| Mm_EntrezGene = 17082
| Mm_Ensembl = ENSMUSG00000026069
| Mm_RefseqmRNA = NM_001025602
| Mm_RefseqProtein = NP_001020773
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 40374143
| Mm_GenLoc_end = 40409958
| Mm_Uniprot = Q3UM53
}}
}}
'''Interleukin 1 receptor-like 1''', also known as '''IL1RL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.<ref>{{cite web | title = Entrez Gene: IL1RL1 interleukin 1 receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9173| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LRP8... {November 10, 2007 2:06:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:07:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
| HGNCid = 6700
| Symbol = LRP8
| AltSymbols =; APOER2; HSZ75190
| OMIM = 602600
| ECnumber =
| Homologene = 31250
| MGIid = 1340044
| GeneAtlas_image1 = PBB_GE_LRP8_205282_at_tn.png
| GeneAtlas_image2 = PBB_GE_LRP8_208433_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008034 |text = lipoprotein binding}} {{GNF_GO|id=GO:0030227 |text = apolipoprotein E receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0045860 |text = positive regulation of protein kinase activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7804
| Hs_Ensembl = ENSG00000157193
| Hs_RefseqProtein = NP_001018064
| Hs_RefseqmRNA = NM_001018054
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 53483800
| Hs_GenLoc_end = 53566409
| Hs_Uniprot = Q14114
| Mm_EntrezGene = 16975
| Mm_Ensembl = ENSMUSG00000028613
| Mm_RefseqmRNA = NM_001080926
| Mm_RefseqProtein = NP_001074395
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 107300193
| Mm_GenLoc_end = 107372099
| Mm_Uniprot = Q924X6
}}
}}
'''Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor''', also known as '''LRP8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.<ref>{{cite web | title = Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7804| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NMT2... {November 10, 2007 2:19:42 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:20:38 PM PST}
- CREATED: Created new protein page: NMT2 {November 10, 2007 2:20:48 PM PST}
- INFO: Beginning work on NRP2... {November 10, 2007 2:13:58 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:15:05 PM PST}
- CREATED: Created new protein page: NRP2 {November 10, 2007 2:15:13 PM PST}
- INFO: Beginning work on NUMB... {November 10, 2007 2:11:43 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NUMB image.jpg {November 10, 2007 2:12:39 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:12:48 PM PST}
- CREATED: Created new protein page: NUMB {November 10, 2007 2:12:58 PM PST}
- INFO: Beginning work on PDCD6... {November 10, 2007 2:21:41 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PDCD6 image.jpg {November 10, 2007 2:21:59 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:22:41 PM PST}
- CREATED: Created new protein page: PDCD6 {November 10, 2007 2:22:52 PM PST}
- INFO: Beginning work on SMARCA5... {November 10, 2007 2:10:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:11:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
| HGNCid = 11101
| Symbol = SMARCA5
| AltSymbols =; ISWI; SNF2H; WCRF135; hISWI; hSNF2H
| OMIM = 603375
| ECnumber =
| Homologene = 55764
| MGIid = 1935129
| GeneAtlas_image1 = PBB_GE_SMARCA5_213251_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCA5_202303_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMARCA5_213859_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042393 |text = histone binding}}
| Component = {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0031213 |text = RSF complex}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016584 |text = nucleosome positioning}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8467
| Hs_Ensembl = ENSG00000153147
| Hs_RefseqProtein = NP_003592
| Hs_RefseqmRNA = NM_003601
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 144654066
| Hs_GenLoc_end = 144694016
| Hs_Uniprot = O60264
| Mm_EntrezGene = 93762
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_053124
| Mm_RefseqProtein = NP_444354
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5''', also known as '''SMARCA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.<ref>{{cite web | title = Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8467| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dirscherl SS, Krebs JE |title=Functional diversity of ISWI complexes. |journal=Biochem. Cell Biol. |volume=82 |issue= 4 |pages= 482-9 |year= 2005 |pmid= 15284901 |doi= 10.1139/o04-044 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF14... {November 10, 2007 2:12:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNFRSF14 image.jpg {November 10, 2007 2:13:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:13:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFRSF14_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jma.
| PDB = {{PDB2|1jma}}, {{PDB2|2aw2}}
| Name = Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
| HGNCid = 11912
| Symbol = TNFRSF14
| AltSymbols =; TR2; ATAR; HVEA; HVEM; LIGHTR
| OMIM = 602746
| ECnumber =
| Homologene = 2833
| MGIid = 2675303
| GeneAtlas_image1 = PBB_GE_TNFRSF14_209354_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005031 |text = tumor necrosis factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8764
| Hs_Ensembl = ENSG00000157873
| Hs_RefseqProtein = NP_003811
| Hs_RefseqmRNA = NM_003820
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 2479150
| Hs_GenLoc_end = 2486613
| Hs_Uniprot = Q92956
| Mm_EntrezGene = 230979
| Mm_Ensembl = ENSMUSG00000042333
| Mm_RefseqmRNA = NM_178931
| Mm_RefseqProtein = NP_849262
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 153766010
| Mm_GenLoc_end = 153771877
| Mm_Uniprot =
}}
}}
'''Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)''', also known as '''TNFRSF14''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.<ref>{{cite web | title = Entrez Gene: TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8764| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPT1... {November 10, 2007 2:02:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TPT1 image.jpg {November 10, 2007 2:04:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:04:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TPT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yz1.
| PDB = {{PDB2|1yz1}}, {{PDB2|2hr9}}
| Name = Tumor protein, translationally-controlled 1
| HGNCid = 12022
| Symbol = TPT1
| AltSymbols =; FLJ27337; HRF; TCTP; p02
| OMIM = 600763
| ECnumber =
| Homologene = 55730
| MGIid = 104890
| GeneAtlas_image1 = PBB_GE_TPT1_216520_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TPT1_207783_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TPT1_211943_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005771 |text = multivesicular body}} {{GNF_GO|id=GO:0045298 |text = tubulin complex}}
| Process = {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7178
| Hs_Ensembl = ENSG00000133112
| Hs_RefseqProtein = NP_003286
| Hs_RefseqmRNA = NM_003295
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 44809008
| Hs_GenLoc_end = 44813505
| Hs_Uniprot = P13693
| Mm_EntrezGene = 22070
| Mm_Ensembl = ENSMUSG00000060126
| Mm_RefseqmRNA = NM_009429
| Mm_RefseqProtein = NP_033455
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 74579584
| Mm_GenLoc_end = 74581515
| Mm_Uniprot = P63028
}}
}}
'''Tumor protein, translationally-controlled 1''', also known as '''TPT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRRAP... {November 10, 2007 2:08:47 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 2:10:07 PM PST}
- CREATED: Created new protein page: TRRAP {November 10, 2007 2:10:16 PM PST}
- INFO: Beginning work on TUBA1B... {November 10, 2007 2:22:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TUBA1B image.jpg {November 10, 2007 2:25:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:25:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUBA1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, alpha 1b
| HGNCid = 18809
| Symbol = TUBA1B
| AltSymbols =; K-ALPHA-1
| OMIM = 602530
| ECnumber =
| Homologene = 81745
| MGIid = 107804
| GeneAtlas_image1 = PBB_GE_TUBA1B_201090_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBA1B_209251_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBA1B_211058_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10376
| Hs_Ensembl = ENSG00000123416
| Hs_RefseqProtein = NP_006073
| Hs_RefseqmRNA = NM_006082
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 47807836
| Hs_GenLoc_end = 47811571
| Hs_Uniprot = P68363
| Mm_EntrezGene = 22143
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011654
| Mm_RefseqProtein = NP_035784
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tubulin, alpha 1b''', also known as '''TUBA1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Venter JC |title=Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. |journal=J. Pharm. Pharmacol. |volume=45 Suppl 1 |issue= |pages= 355-60 |year= 1993 |pmid= 8098743 |doi= }}
*{{cite journal | author=Lopez-Fanarraga M, Avila J, Guasch A, ''et al.'' |title=Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 219-29 |year= 2002 |pmid= 11580271 |doi= 10.1006/jsbi.2001.4386 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UROD... {November 10, 2007 2:05:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein UROD image.jpg {November 10, 2007 2:06:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:06:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UROD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jph.
| PDB = {{PDB2|1jph}}, {{PDB2|1jpi}}, {{PDB2|1jpk}}, {{PDB2|1r3q}}, {{PDB2|1r3r}}, {{PDB2|1r3s}}, {{PDB2|1r3t}}, {{PDB2|1r3v}}, {{PDB2|1r3w}}, {{PDB2|1r3y}}, {{PDB2|1uro}}
| Name = Uroporphyrinogen decarboxylase
| HGNCid = 12591
| Symbol = UROD
| AltSymbols =; PCT
| OMIM = 176100
| ECnumber =
| Homologene = 320
| MGIid = 98916
| GeneAtlas_image1 = PBB_GE_UROD_208970_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UROD_208971_at_tn.png
| Function = {{GNF_GO|id=GO:0004853 |text = uroporphyrinogen decarboxylase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006779 |text = porphyrin biosynthetic process}} {{GNF_GO|id=GO:0006783 |text = heme biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7389
| Hs_Ensembl = ENSG00000126088
| Hs_RefseqProtein = NP_000365
| Hs_RefseqmRNA = NM_000374
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 45250417
| Hs_GenLoc_end = 45253928
| Hs_Uniprot = P06132
| Mm_EntrezGene = 22275
| Mm_Ensembl = ENSMUSG00000028684
| Mm_RefseqmRNA = NM_009478
| Mm_RefseqProtein = NP_033504
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 116488150
| Mm_GenLoc_end = 116492307
| Mm_Uniprot = Q91VW4
}}
}}
'''Uroporphyrinogen decarboxylase''', also known as '''UROD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.<ref>{{cite web | title = Entrez Gene: UROD uroporphyrinogen decarboxylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7389| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VKORC1... {November 10, 2007 2:25:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:26:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Vitamin K epoxide reductase complex, subunit 1
| HGNCid = 23663
| Symbol = VKORC1
| AltSymbols =; EDTP308; FLJ00289; IMAGE3455200; MGC2694; MST134; MST576; VKCFD2; VKOR
| OMIM = 608547
| ECnumber =
| Homologene = 11416
| MGIid = 106442
| GeneAtlas_image1 = PBB_GE_VKORC1_217949_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0047057 |text = vitamin-K-epoxide reductase (warfarin-sensitive) activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0042373 |text = vitamin K metabolic process}} {{GNF_GO|id=GO:0050820 |text = positive regulation of coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79001
| Hs_Ensembl = ENSG00000167397
| Hs_RefseqProtein = NP_076869
| Hs_RefseqmRNA = NM_024006
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 31009956
| Hs_GenLoc_end = 31013551
| Hs_Uniprot = Q9BQB6
| Mm_EntrezGene = 27973
| Mm_Ensembl = ENSMUSG00000030804
| Mm_RefseqmRNA = NM_178600
| Mm_RefseqProtein = NP_848715
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 127684211
| Mm_GenLoc_end = 127686765
| Mm_Uniprot = Q9CRC0
}}
}}
'''Vitamin K epoxide reductase complex, subunit 1''', also known as '''VKORC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: VKORC1 vitamin K epoxide reductase complex, subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79001| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oldenburg J, Bevans CG, Müller CR, Watzka M |title=Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. |journal=Antioxid. Redox Signal. |volume=8 |issue= 3-4 |pages= 347-53 |year= 2006 |pmid= 16677080 |doi= 10.1089/ars.2006.8.347 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZEB2... {November 10, 2007 2:20:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ZEB2 image.jpg {November 10, 2007 2:21:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 2:21:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ZEB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2da7.
| PDB = {{PDB2|2da7}}
| Name = Zinc finger E-box binding homeobox 2
| HGNCid = 14881
| Symbol = ZEB2
| AltSymbols =; SIP1; SIP-1; KIAA0569; SMADIP1; ZFHX1B
| OMIM = 605802
| ECnumber =
| Homologene = 8868
| MGIid = 1344407
| GeneAtlas_image1 = PBB_GE_ZEB2_203603_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0019208 |text = phosphatase regulator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0048598 |text = embryonic morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9839
| Hs_Ensembl = ENSG00000169554
| Hs_RefseqProtein = NP_055610
| Hs_RefseqmRNA = NM_014795
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 144862055
| Hs_GenLoc_end = 144994386
| Hs_Uniprot = O60315
| Mm_EntrezGene = 24136
| Mm_Ensembl = ENSMUSG00000026872
| Mm_RefseqmRNA = NM_001033635
| Mm_RefseqProtein = NP_001028807
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 44809127
| Mm_GenLoc_end = 44935233
| Mm_Uniprot = Q3URW5
}}
}}
'''Zinc finger E-box binding homeobox 2''', also known as '''ZEB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (TCF8; MIM 189909)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs (see MIM 605568).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: ZEB2 zinc finger E-box binding homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9839| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mowat DR, Wilson MJ, Goossens M |title=Mowat-Wilson syndrome. |journal=J. Med. Genet. |volume=40 |issue= 5 |pages= 305-10 |year= 2003 |pmid= 12746390 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
