UCHL3

UCHL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UCH, 1XD3
Identifiers
Aliases	UCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDs	OMIM: 603090; MGI: 1355274; HomoloGene: 4377; GeneCards: UCHL3; OMA:UCHL3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	75,606,020 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	101,933,561 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; islet of Langerhans; ; left adrenal cortex; ; mucosa of esophagus; ; rectum; ; skin of leg; ; gastrocnemius muscle; ; skin of abdomen;
	Top expressed in
	left ventricle; ; interventricular septum; ; spermatid; ; epiblast; ; embryo; ; spermatocyte; ; neural tube; ; esophagus; ; placenta; ; Mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cysteine-type peptidase activity; hydrolase activity; peptidase activity; ubiquitin binding; NEDD8-specific protease activity; thiol-dependent deubiquitinase;
Cellular component	nucleus; intracellular anatomical structure; cytoplasm; cytosol;
Biological process	protein catabolic process; proteolysis; ubiquitin-dependent protein catabolic process; post-translational protein modification; protein deubiquitination; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7347
	50933
	ENSG00000118939
	ENSMUSG00000022111
	P15374
	Q9JKB1
	NM_001270952; NM_006002
	NM_016723
	NP_001257881; NP_005993
	NP_057932
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.^[5]^[6]

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118939 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022111 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. Bibcode:1989Sci...246..670W. doi:10.1126/science.2530630. PMID 2530630.
^ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
^ Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. S2CID 28207136.
^ Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

Johnston SC, Larsen CN, Cook WJ, et al. (1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". EMBO J. 16 (13): 3787–96. doi:10.1093/emboj/16.13.3787. PMC 1170002. PMID 9233788.
Wilkinson KD, Laleli-Sahin E, Urbauer J, et al. (1999). "The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3". J. Mol. Biol. 291 (5): 1067–77. doi:10.1006/jmbi.1999.3038. PMID 10518943.
Baek SH, Yoo YJ, Tanaka K, Chung CH (1999). "Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution". Biochem. Biophys. Res. Commun. 264 (1): 235–40. doi:10.1006/bbrc.1999.1492. PMID 10527871.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
Nam MJ, Madoz-Gurpide J, Wang H, et al. (2004). "Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3". Proteomics. 3 (11): 2108–15. doi:10.1002/pmic.200300594. PMID 14595809. S2CID 27511690.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Misaghi S, Galardy PJ, Meester WJ, et al. (2005). "Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate". J. Biol. Chem. 280 (2): 1512–20. doi:10.1074/jbc.M410770200. PMID 15531586.
Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118939 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022111 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2530630-5] Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. Bibcode:1989Sci...246..670W. doi:10.1126/science.2530630. PMID 2530630.

[entrez-6] "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".

[pmid21762696-7] Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. S2CID 28207136.

[pmid9790970-8] Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Thioesterases (EC 3.1.2)
Acetyl-CoA thioesterases
Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4 ACOT6 ACOT7 ACOT8 ACOT9 ACOT11 ACOT12 ACOT13
Formyl-CoA thioesterases
Palmitoyl protein thioesterases	PPT1 PPT2
Succinyl-CoA thioesterases
Ubiquitin C-terminal hydrolases	UCHL1 UCHL3 UCHL5

UCHL3

Interactions

See also

References

Further reading