Tropomodulin 3

TMOD3
Identifiers
Aliases	TMOD3, UTMOD, tropomodulin 3
External IDs	OMIM: 605112; MGI: 1355315; HomoloGene: 8727; GeneCards: TMOD3; OMA:TMOD3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	51,947,295 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,466,939 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; oral cavity; ; buccal mucosa cell; ; gums; ; lower lobe of lung; ; gingival epithelium; ; epithelium of colon; ; skin of hip; ; Achilles tendon; ; mucosa of sigmoid colon;
	Top expressed in
	lactiferous gland; ; Ileal epithelium; ; corneal stroma; ; left lung lobe; ; sciatic nerve; ; cardiac muscle tissue of left ventricle; ; seminal vesicula; ; right lung lobe; ; blood; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; cadherin binding involved in cell-cell adhesion; tropomyosin binding;
Cellular component	cytoplasm; cytoskeleton; striated muscle thin filament; myofibril;
Biological process	pointed-end actin filament capping; positive regulation of mitotic cell cycle phase transition; actin cytoskeleton organization; erythrocyte development; cell-cell adhesion; muscle contraction; actin filament organization; myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	29766
	50875
	ENSG00000138594
	ENSMUSG00000058587
	Q9NYL9
	Q9JHJ0
	NM_014547
	NM_016963; NM_001357828
	NP_055362
	NP_058659; NP_001344757
	Wikidata
View/Edit Human	View/Edit Mouse

^[5]

^[6]

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fischer, Robert S.; Yarmola, Elena G.; Weber, Kari L.; Speicher, Kaye D.; Speicher, David W.; Bubb, Michael R.; Fowler, Velia M. (2006-11-24). "Tropomodulin 3 Binds to Actin Monomers". Journal of Biological Chemistry. 281 (47): 36454–36465. doi:10.1074/jbc.M606315200. ISSN 0021-9258. PMID 17012745.
^ "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility (PDF Download Available)". ResearchGate. Retrieved 2017-03-28.
^ Cox PR, Zoghbi HY (Apr 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
^ "Entrez Gene: TMOD3 tropomodulin 3 (ubiquitous)".

Weber KL, Fischer RS, Fowler VM (2008). "Tmod3 regulates polarized epithelial cell morphology". J. Cell Sci. 120 (Pt 20): 3625–32. doi:10.1242/jcs.011445. PMID 17928307.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Fischer RS, Yarmola EG, Weber KL, et al. (2007). "Tropomodulin 3 binds to actin monomers". J. Biol. Chem. 281 (47): 36454–65. doi:10.1074/jbc.M606315200. PMID 17012745.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Fischer RS, Fritz-Six KL, Fowler VM (2003). "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility". J. Cell Biol. 161 (2): 371–80. doi:10.1083/jcb.200209057. PMC 2172920. PMID 12707310.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138594 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058587 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Fischer, Robert S.; Yarmola, Elena G.; Weber, Kari L.; Speicher, Kaye D.; Speicher, David W.; Bubb, Michael R.; Fowler, Velia M. (2006-11-24). "Tropomodulin 3 Binds to Actin Monomers". Journal of Biological Chemistry. 281 (47): 36454–36465. doi:10.1074/jbc.M606315200. ISSN 0021-9258. PMID 17012745.

[6] "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility (PDF Download Available)". ResearchGate. Retrieved 2017-03-28.

[pmid10662549-7] Cox PR, Zoghbi HY (Apr 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.

[entrez-8] "Entrez Gene: TMOD3 tropomodulin 3 (ubiquitous)".

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References

Further reading