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Tibor Juhasz

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Tibor Juhasz
Occupation(s)Physicist, academic
Awards
Academic background
EducationUniversity of Szeged (Dipl. Phys.)
University of California, Irvine (Ph.D.)
Academic work
InstitutionsUniversity of California, Irvine
ViaLase Inc

Tibor Juhasz is an American-Hungarian physicist and an academic. He is a professor at the Gavin Herbert Eye Institute and the Department of Biomedical Engineering at the University of California, Irvine[1] as well as the CEO of ViaLase.[2]

Juhasz is most known for his work on medical applications of lasers, laser-tissue interactions, tissue biomechanics, and biomedical imaging.[3] He is the recipient of the 2002 Berthold Leibinger Innovation Prize for the development and commercialization of femtosecond laser surgical technology as well as the 2022 Golden Goose Award of the American Association for the Advancement of Science and Association of American Universities for introducing femtosecond laser technology to ophthalmology.[4]

Education

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Juhasz completed his Diploma in Physics from JATE University of Szeged in 1982 followed by a Ph.D. in Physics from the same institution in 1986. He completed his postdoctoral education at the Department of Physics and Astronomy, at UC Irvine from 1987 to 1990. Later in 2001, he obtained a Doctor of Sciences degree from the Hungarian Academy of Sciences.[1][5]

Career

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Juhasz began his academic career in 1982 at the Technical University of Budapest, where he held various positions, including research assistant in the Department of External Physics from 1982 to 1985 and assistant professor from 1985 to 1986. In 1987, he joined the Department of Physics at the University of California, where he was postgraduate researcher from 1987 to 1990, and assistant researcher physicist from 1990 to 1994. Between 1996 and 1998, he was a senior associate research scientist at Kellogg Eye Center and the Center for Ultrafast Optical Sciences at the University of Michigan, Ann Arbor. From 1998 to 2004, he served as an associate professor in the Department of Biomedical Engineering and Kellogg Eye Center at the University of Michigan. Since 2004, he has been a professor at the Gavin Herbert Eye Institute and the Department of Biomedical Engineering at the University of California, Irvine.[1]

Juhasz co-founded IntraLase Corporation. At IntraLase Corporation, he served as vice president for R&D until 2002 and later took on the role of chief technology officer from 2002 to 2007. Subsequently, in 2008, he co-founded Lensx Lasers. During his time at Lensx Lasers, he served as chief technology officer from 2008 to 2010. From 2010 to 2016, he held the position of vice president of R&D at Alcon LenSx. In 2017, he founded ViaLase, and has since been serving as its CEO.[2]

Research

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Juhasz has conducted research in the field of femtosecond laser applications in ophthalmology. With over 25 US patents to his name, his research encompasses projects, including femtosecond laser applications in Corneal Surgery, Cataract Surgery and the development of an image-guided non-invasive femtosecond laser treatment for Glaucoma.[3]

Femtosecond lasers in corneal surgery

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Juhasz started his research career investigating interactions between ultrashort laser pulses and matter.[6][7][8] This turned his attention towards medical applications of femtosecond lasers. After establishing that femtosecond laser pulses have confined tissue effects with minimized collateral damage he led the development of the first commercially available ophthalmic femtosecond laser.[9][10] He collaborated with Ron Kurtz, Gerard Mourou, and IntraLase Corp to conduct investigations into the applications of femtosecond lasers in corneal surgery. He demonstrated that the utilization of femtosecond laser technology for flap creation in LASIK surgery offers enhanced safety and yields superior refractive outcomes in comparison to the conventional microkeratome method.[11][12][13] Furthermore, his work established that employing femtosecond laser technology for corneal transplantation offers distinct benefits in comparison to conventional methods.[14][15][16]

Femtosecond laser cataract surgery

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In collaboration with, Ron Kurtz, Zoltan Nagy, and Alcon LenSx, Juhasz worked on the development and investigation of clinical applications of femtosecond lasers in cataract surgery.[17] He led the design and development of the first clinical cataract femtosecond laser.[18] Ultimately, he demonstrated that the mechanical strength of femtosecond laser capsulotomy is on par with that of manual capsulotomy, but with a significantly reduced variability in strength. Consequently, these studies significantly decreased the likelihood and rate of capsular tears and other complications.[19][20]

Non-invasive OCT image-guided femtosecond laser treatment for glaucoma

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Concentrating his research efforts further on the clinical applications of the ophthalmic femtosecond laser technology, Juhasz undertook a research project supported by the National Institutes of Health (NIH), which aimed to reduce intraocular pressure (IOP) by establishing partial thickness channels from the front chamber (AC) to the area beneath the conjunctiva through the sclera.[21][22] Although the channels proved to be efficient, his early animal experiments showed a swift healing response, which subsequently constrained the long-term efficacy of these treatments. To counter this, he developed a micron-resolution OCT imaging technology.[23][24] Later, he demonstrated that by using micron-resolution OCT imaging, it is possible to precisely identify the trabecular meshwork and create precise drainage pathways that connect the anterior chamber to Schlemm's canal.[25][26][27] Additionally, he showed in preserved human cadaver eyes that the femtosecond laser-generated drainage pathways have the potential to reduce intraocular pressure (IOP).[28] His company ViaLase developed a clinical device that, in initial human trials, demonstrated a highly favorable safety record and delivered effective, long-lasting results over a two-year follow-up period.[29][30]

In addition to his work in clinical applications of femtosecond lasers, Juhasz also performed important research in the field of corneal biomechanics[citation needed] and in the field of the treatment of keratoconus.[31][32][33]

Awards and honors

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  • 2002 – Berthold Leibinger Innovation Prize, Berthold Leibinger Stiftung
  • 2013 – Doctor Honoris Causa, Semmelweis University
  • 2016 – External Member, Hungarian Academy of Sciences[34]
  • 2022 – Golden Goose Award, American Association for the Advancement of Science and Association of American Universities[35]
  • 2023 – Entrepreneurial Leader of the Year, UC Irvine

Selected articles

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  • Juhasz, Tibor; Kastis, George A.; Suárez, Carlos; Bor, Zsolt; Bron, Walter E. (1996). "Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water". Lasers in Surgery and Medicine. 19 (1): 23–31. doi:10.1002/(SICI)1096-9101(1996)19:1<23::AID-LSM4>3.0.CO;2-S. PMID 8836993. S2CID 23193533.
  • Juhasz, T.; Loesel, F.H.; Kurtz, R.M.; Horvath, C.; Bille, J.F.; Mourou, G. (1999). "Corneal refractive surgery with femtosecond lasers". IEEE Journal of Selected Topics in Quantum Electronics. 5 (4): 902–910. Bibcode:1999IJSTQ...5..902J. doi:10.1109/2944.796309.
  • Ratkay-Traub, Imola; Ferincz, Istvan E; Juhasz, Tibor; Kurtz, Ron M; Krueger, Ronald R (March 2003). "First Clinical Results With the Femtosecond Neodynium-glass Laser in Refractive Surgery". Journal of Refractive Surgery. 19 (2): 94–99. doi:10.3928/1081-597X-20030301-03. PMID 12701713.
  • Nordan, Lee T; Slade, Stephen G; Baker, Richard N; Suarez, Carlos; Juhasz, Tibor; Kurtz, Ron (January 2003). "Femtosecond Laser Flap Creation for Laser in situ Keratomileusis: Six-month Follow-up of Initial U.S. Clinical Series". Journal of Refractive Surgery. 19 (1): 8–9. doi:10.3928/1081-597X-20030101-03. PMID 12553599.
  • Mikula, Eric R.; Raksi, Ferenc; Ahmed, Iqbal Ike; Sharma, Manu; Holland, Guy; Khazaeinezhad, Reza; Bradford, Samantha; Jester, James V.; Juhasz, Tibor (25 March 2022). "Femtosecond Laser Trabeculotomy in Perfused Human Cadaver Anterior Segments: A Novel, Noninvasive Approach to Glaucoma Treatment". Translational Vision Science & Technology. 11 (3): 28. doi:10.1167/tvst.11.3.28. PMC 8963660. PMID 35333286.
  • Nagy, Zoltan Z.; Kranitz, Kinga; Ahmed, Iqbal Ike K.; De Francesco, Ticiana; Mikula, Eric; Juhasz, Tibor (December 2023). "First-in-Human Safety Study of Femtosecond Laser Image-Guided Trabeculotomy for Glaucoma Treatment". Ophthalmology Science. 3 (4): 100313. doi:10.1016/j.xops.2023.100313. PMC 10285639. PMID 37363134.
  • Luo, Shangbang; Mikula, Eric; Khazaeinezhad, Reza; Bradford, Samantha; Zhang, Fengyi; Jester, James; Juhasz, Tibor (April 2024). "Evaluating the effect of pulse energy on femtosecond laser trabeculotomy (FLT) outflow channels for glaucoma treatment in human cadaver eyes". Lasers in Surgery and Medicine. 56 (4): 382–391. doi:10.1002/lsm.23783. PMC 11361556. PMID 38570914.

References

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  1. ^ a b c "Tibor Juhasz | Samueli School of Engineering at UC Irvine". engineering.uci.edu.
  2. ^ a b "Vialase ® | Redefining Glaucoma Treatment". Vialase.
  3. ^ a b "Tibor Juhasz - Google Scholar".
  4. ^ "Awardees". The Golden Goose Award.
  5. ^ "Grabbing the Golden Goose". 23 January 2023.
  6. ^ Juhasz, T.; Bron, W. (November 1989). "Subpicosecond-resolved polariton decay". Physical Review Letters. 63 (21): 2385–2388. Bibcode:1989PhRvL..63.2385J. doi:10.1103/PhysRevLett.63.2385. PMID 10040875.[non-primary source needed]
  7. ^ Bron, W. E.; Juhasz, T.; Mehta, S. (3 April 1989). "New nonequilibrium phonon state". Physical Review Letters. 62 (14): 1655–1658. Bibcode:1989PhRvL..62.1655B. doi:10.1103/PhysRevLett.62.1655. PMID 10039730.[non-primary source needed]
  8. ^ Smith, G. O.; Juhasz, T.; Bron, W. E.; Levinson, Y. B. (13 April 1992). "Interaction of an electron-hole plasma with optical phonons in GaP". Physical Review Letters. 68 (15): 2366–2369. Bibcode:1992PhRvL..68.2366S. doi:10.1103/PhysRevLett.68.2366. PMID 10045377.[non-primary source needed]
  9. ^ Juhasz, Tibor; Kastis, George A.; Suárez, Carlos; Bor, Zsolt; Bron, Walter E. (1996). "Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water". Lasers in Surgery and Medicine. 19 (1): 23–31. doi:10.1002/(SICI)1096-9101(1996)19:1<23::AID-LSM4>3.0.CO;2-S. PMID 8836993. S2CID 23193533.[non-primary source needed]
  10. ^ Juhasz, T.; Loesel, F.H.; Kurtz, R.M.; Horvath, C.; Bille, J.F.; Mourou, G. (1999). "Corneal refractive surgery with femtosecond lasers". IEEE Journal of Selected Topics in Quantum Electronics. 5 (4): 902–910. Bibcode:1999IJSTQ...5..902J. doi:10.1109/2944.796309.[non-primary source needed]
  11. ^ Cabrera Fernández, Delia; Niazy, A. M.; Kurtz, R. M.; Djotyan, G. P.; Juhasz, T. (2005). "Finite element analysis applied to cornea reshaping". Journal of Biomedical Optics. 10 (6): 064018. Bibcode:2005JBO....10f4018C. doi:10.1117/1.2136149. PMID 16409083.[non-primary source needed]
  12. ^ Tran, Dan B.; Sarayba, Melvin A.; Bor, Zsolt; Garufis, Carrie; Duh, Yi-Jing; Soltes, Charles R.; Juhasz, Tibor; Kurtz, Ron M. (January 2005). "Randomized prospective clinical study comparing induced aberrations with IntraLase and Hansatome flap creation in fellow eyes: Potential impact on wavefront-guided laser in situ keratomileusis". Journal of Cataract and Refractive Surgery. 31 (1): 97–105. doi:10.1016/j.jcrs.2004.10.037. PMID 15721701. S2CID 21831666.[non-primary source needed]
  13. ^ Fernández, D. Cabrera; Niazy, A. M.; Kurtz, R. M.; Djotyan, G. P.; Juhasz, T. (22 March 2006). "A Finite Element Model for Ultrafast Laser–Lamellar Keratoplasty". Annals of Biomedical Engineering. 34 (1): 169–183. doi:10.1007/s10439-005-9014-3. PMID 16474919. S2CID 26968302.[non-primary source needed]
  14. ^ Soong, H; Mian, S; Abbasi, O; Juhasz, T (January 2005). "Femtosecond laser–assisted posterior lamellar keratoplastyInitial studies of surgical technique in eye bank eyes". Ophthalmology. 112 (1): 44–49. doi:10.1016/j.ophtha.2004.06.037. PMID 15629819.[non-primary source needed]
  15. ^ Sarayba, Melvin A; Juhasz, Tibor; Chuck, Roy S; Ignacio, Teresa S; Nguyen, Thao B; Sweet, Paula; Kurtz, Ronald M (April 2005). "Femtosecond Laser Posterior Lamellar Keratoplasty: A Laboratory Model". Cornea. 24 (3): 328–333. doi:10.1097/01.ico.0000138830.50112.f4. PMID 15778607. S2CID 33175561.[non-primary source needed]
  16. ^ Fernández, D Cabrera; Niazy, A M; Kurtz, R M; Djotyan, G P; Juhasz, T (March 2006). "Biomechanical Model of Corneal Transplantation". Journal of Refractive Surgery. 22 (3): 293–302. doi:10.3928/1081-597X-20060301-16. PMID 16602319.[non-primary source needed]
  17. ^ ""Revolutionary" Hungarian Invention Used To Improve American Fighter Pilots' Eyesight". 30 August 2016.
  18. ^ Winkler, Moritz; Shoa, Golroxan; Xie, Yilu; Petsche, Steven J.; Pinsky, Peter M.; Juhasz, Tibor; Brown, Donald J.; Jester, James V. (5 November 2013). "Three-Dimensional Distribution of Transverse Collagen Fibers in the Anterior Human Corneal Stroma". Investigative Ophthalmology & Visual Science. 54 (12): 7293–7501. doi:10.1167/iovs.13-13150. PMC 4589141. PMID 24114547.[non-primary source needed]
  19. ^ Mikula, Eric R.; Jester, James V.; Juhasz, Tibor (21 June 2016). "Measurement of an Elasticity Map in the Human Cornea". Investigative Ophthalmology & Visual Science. 57 (7): 3282–3286. doi:10.1167/iovs.15-18248. PMC 4961063. PMID 27327584.[non-primary source needed]
  20. ^ Mikula, Eric; Winkler, Moritz; Juhasz, Tibor; Brown, Donald J.; Shoa, Golroxan; Tran, Stephanie; Kenney, M. Cristina; Jester, James V. (October 2018). "Axial mechanical and structural characterization of keratoconus corneas". Experimental Eye Research. 175: 14–19. doi:10.1016/j.exer.2018.05.019. PMC 7324026. PMID 29842851.[non-primary source needed]
  21. ^ Sacks, Zachary S.; Kurtz, Ron M.; Juhasz, Tibor; Mourau, Gerard A. (2002). "High precision subsurface photodisruption in human sclera". Journal of Biomedical Optics. 7 (3): 442–450. Bibcode:2002JBO.....7..442S. doi:10.1117/1.1482381. PMID 12175295.[non-primary source needed]
  22. ^ Chaudhary, Gautam; Rao, Bin; Chai, Dongyul; Chen, Zhongping; Juhasz, Tibor (2007). "Investigation and visualization of scleral channels created with femtosecond laser in enucleated human eyes using 3D optical coherence tomography images". In Manns, Fabrice; Soederberg, Per G.; Ho, Arthur; Stuck, Bruce E.; Belkin, Michael (eds.). Ophthalmic Technologies XVII. Vol. 6426. pp. 64260B. doi:10.1117/12.701297. S2CID 122311420.[non-primary source needed]
  23. ^ Luo, Shangbang; Holland, Guy; Mikula, Eric; Bradford, Samantha; Khazaeinezhad, Eric; Jester, James; Juhasz, Tibor (May 2022). "Dispersion compensation for spectral domain optical coherence tomography by time-frequency analysis and iterative optimization". Optics Continuum. 1 (5): 1117–1136. doi:10.1364/OPTCON.455242.
  24. ^ Luo, Shangbang; Holland, Guy; Khazaeinezhad, Reza; Bradford, Samantha; Joshi, Rohan; Juhasz, Tibor (24 August 2023). "Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography". Scientific Reports. 13 (1): 13861. Bibcode:2023NatSR..1313861L. doi:10.1038/s41598-023-37248-0. PMC 10449890. PMID 37620338.[non-primary source needed]
  25. ^ Luo, Shangbang; Mikula, Eric; Khazaeinezhad, Reza; Bradford, Samantha; Zhang, Fengyi; Jester, James; Juhasz, Tibor (April 2024). "Evaluating the effect of pulse energy on femtosecond laser trabeculotomy (FLT) outflow channels for glaucoma treatment in human cadaver eyes". Lasers in Surgery and Medicine. 56 (4): 382–391. doi:10.1002/lsm.23783. PMC 11361556. PMID 38570914.
  26. ^ Mikula, Eric; Holland, Guy; Bradford, Samantha; Khazaeinezhad, Reza; Srass, Hadi; Suarez, Carlos; Jester, James V.; Juhasz, Tibor (18 August 2021). "Intraocular Pressure Reduction by Femtosecond Laser Created Trabecular Channels in Perfused Human Anterior Segments". Translational Vision Science & Technology. 10 (9): 22. doi:10.1167/tvst.10.9.22. PMC 8374973. PMID 34406341.[non-primary source needed]
  27. ^ "Nonlinear collagen crosslinking using a single, amplified, femtosecond laser pulse".
  28. ^ Mikula, Eric R.; Raksi, Ferenc; Ahmed, Iqbal Ike; Sharma, Manu; Holland, Guy; Khazaeinezhad, Reza; Bradford, Samantha; Jester, James V.; Juhasz, Tibor (25 March 2022). "Femtosecond Laser Trabeculotomy in Perfused Human Cadaver Anterior Segments: A Novel, Noninvasive Approach to Glaucoma Treatment". Translational Vision Science & Technology. 11 (3): 28. doi:10.1167/tvst.11.3.28. PMC 8963660. PMID 35333286.[non-primary source needed]
  29. ^ "WIPO - Search International and National Patent Collections". patentscope.wipo.int.
  30. ^ Nagy, Zoltan Z.; Kranitz, Kinga; Ahmed, Iqbal Ike K.; De Francesco, Ticiana; Mikula, Eric; Juhasz, Tibor (December 2023). "First-in-Human Safety Study of Femtosecond Laser Image-Guided Trabeculotomy for Glaucoma Treatment". Ophthalmology Science. 3 (4): 100313. doi:10.1016/j.xops.2023.100313. PMC 10285639. PMID 37363134.[non-primary source needed]
  31. ^ "Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea".
  32. ^ "Surgical treatment for glaucoma".
  33. ^ Chai, Dongyul; Juhasz, Tibor; Brown, Donald J.; Jester, James V. (20 March 2013). "Nonlinear optical collagen cross-linking and mechanical stiffening: a possible photodynamic therapeutic approach to treating corneal ectasia". Journal of Biomedical Optics. 18 (3): 038003. Bibcode:2013JBO....18c8003C. doi:10.1117/1.JBO.18.3.038003. PMC 3603223. PMID 23515869.[non-primary source needed]
  34. ^ "Introducing the newly elected members of the Hungarian Academy of Sciences". MTA.hu. May 12, 2016.
  35. ^ "2022 Golden Goose Award Honors Serendipitous Science".
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