Talk:11-Deoxycortisol

Text and/or other creative content from Cortodoxone was copied or moved into 11-Deoxycortisol. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

This is the talk page for discussing improvements to the 11-Deoxycortisol article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: Index, 1: 2 years

Pharmacology Low‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Low	This article has been rated as Low-importance on the project's importance scale.

Psychology Low‑importance

	Psychology portal This article is within the scope of WikiProject Psychology, a collaborative effort to improve the coverage of Psychology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PsychologyWikipedia:WikiProject PsychologyTemplate:WikiProject Psychologypsychology articles
Low	This article has been rated as Low-importance on the project's importance scale.

Chemicals Mid‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Molecular Biology: MCB Low‑importance

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
Low	This article has been rated as Low-importance on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Physiology Low‑importance

	This article is within the scope of WikiProject Physiology, a collaborative effort to improve the coverage of Physiology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PhysiologyWikipedia:WikiProject PhysiologyTemplate:WikiProject PhysiologyPhysiology articles
Low	This article has been rated as Low-importance on the importance scale.
	This article has not yet been associated with a particular area.

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

Alleged low blood pressure in 21-hydroxylase deficiency

@Christian75:@Medgirl131:@Wimvandorst:@Wimvandorst:@Edgar181:@Maneesh:

On 29 May 2009‎ an unauthenticated user from the IP address 146.203.126.113 added a brief note on clinical relevance of 11-deoxycortisol https://en.wikipedia.org/w/index.php?title=11-Deoxycortisol&oldid=292986319

The disputed addition is (quote): "In 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)."

There were no reference to support these claims.

In fact, in 11-beta-hydroxylase deficiency, it is 11-deoxycorticosterone that leads to hypertension, although it raises together with 11-deoxycortisol, but 11-deoxycortisol itself does not lead to hypertension. I have corrected this and added a reference.

However, I cannot find the explicit reference for the second part of the addition "(as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)". I could not find an article that clearly states that hypotension is a symptom in 21-alpha-hydroxylase deficiency. There were some mentions pressure in some websites (that do not list sources) about low blood pressure in most severe salt-losing forms, but these symptoms are no longer found in most recent articles, reviews and practical guidelines about 21-hydroxylase deficiency.

---Maxim Masiutin (talk) 13:37, 28 September 2020 (UTC)[reply]

I found references (PMID 9809193 and 36807213) to support the claim that in 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids). Maxim Masiutin (talk) 10:00, 26 October 2023 (UTC)[reply]