TP53RK

TP53RK
Identifiers
Aliases	TP53RK, BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB
External IDs	OMIM: 608679; MGI: 1914050; HomoloGene: 6042; GeneCards: TP53RK; OMA:TP53RK - orthologs
EC number	3.6.-.-
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,689,444 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,641,425 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; islet of Langerhans; ; bronchial epithelial cell; ; stromal cell of endometrium; ; gonad; ; cartilage tissue; ; olfactory zone of nasal mucosa; ; right adrenal cortex; ; epithelium of nasopharynx;
	Top expressed in
	spermatid; ; female urethra; ; embryo; ; granulocyte; ; embryo; ; lumbar spinal ganglion; ; primitive streak; ; stroma of kidney; ; epiblast; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; p53 binding; protein binding; ATP binding; hydrolase activity; phosphotransferase activity, alcohol group as acceptor; protein serine/threonine kinase activity;
Cellular component	cytosol; membrane; nucleus; nucleoplasm; EKC/KEOPS complex; cytoplasm;
Biological process	protein phosphorylation; phosphorylation; tRNA threonylcarbamoyladenosine metabolic process; tRNA processing; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	112858
	76367
	ENSG00000172315
	ENSMUSG00000042854
	Q96S44
	Q99PW4
	NM_033550
	NM_023815
	NP_291028
	NP_076304.2
	Wikidata
View/Edit Human	View/Edit Mouse

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.^[5]^[6]^[7] This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control,^[8] telomere regulation ^[9] and tRNA modification.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". The Journal of Biological Chemistry. 276 (47): 44003–11. doi:10.1074/jbc.M105669200. PMID 11546806.
^ Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Letters. 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID 12914926. S2CID 24581860.
^ "Entrez Gene: TP53RK TP53 regulating kinase".
^ Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". The EMBO Journal. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMC 1538566. PMID 16874308.
^ Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.
^ Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A". The EMBO Journal. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMC 3049205. PMID 21183954.

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (Apr 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochemical and Biophysical Research Communications. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.
Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC (Sep 2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516.
Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications. 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042854 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11546806-5] Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". The Journal of Biological Chemistry. 276 (47): 44003–11. doi:10.1074/jbc.M105669200. PMID 11546806.

[pmid12914926-6] Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Letters. 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID 12914926. S2CID 24581860.

[entrez-7] "Entrez Gene: TP53RK TP53 regulating kinase".

[pmid16874308-8] Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". The EMBO Journal. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMC 1538566. PMID 16874308.

[pmid16564010-9] Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.

[pmid21183954-10] Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A". The EMBO Journal. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMC 3049205. PMID 21183954.

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References

Further reading