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Shuguang Zhang

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Shuguang Zhang
Born
Chongqing, China
Known forself-assembling peptides
Academic background
EducationUniversity of California, Santa Barbara (Ph.D.), Sichuan University (B.S.)
Doctoral advisorEduardo Orias
Academic work
DisciplineBiochemistry
Sub-disciplineMolecular Architecture
InstitutionsMassachusetts Institute of Technology
Websitehttps://www.media.mit.edu/people/shuguang/overview/

Shuguang Zhang is an American biochemist. He is at the MIT Media Lab's Laboratory for Molecular Architecture.[1] Shuguang Zhang's research focuses on designs of biological molecules, particularly proteins and peptides. He has published over 200 scientific papers, which have cumulatively been cited over 40,300 times with an h-index of 96.[2][3] On the “Updated science-wide author databases of standardizes citation indicators”,[4] he is ranked 18th worldwide in the field of Biomedical Engineering. Zhang is also a co-founder and board member of Molecular Frontiers Foundation,[5] which organizes annual Molecular Frontiers Symposia in Sweden and around the world.[6] The selected winners are awarded Molecular Frontiers Inquiry Prize.[7]

Early life and education

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Shuguang Zhang received his B.S. in biochemistry from Sichuan University in 1980 and Ph.D. in Biochemistry & Molecular Biology from University of California at Santa Barbara in 1988 (under mentorship of Eduardo Orias). The same year, he joined MIT to work with Alexander Rich.

Career and Scientific Work

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Self-Assembling Peptides

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In 1990, Shuguang Zhang made a serendipitous discovery of a self-assembling peptide in yeast protein Zuotin.[8][9] This discovery led to the development of a new field of peptide nanobiotechnology and to designs of a variety of self-assembling peptides for widespread uses, including peptide hydrogels in materials science, 3D tissue cell culture and tissue engineering, nanomedicine, sustained molecular releases, clinical and surgical applications.[10][11][12][13] He co-founded a startup company 3DMatrix that brings the self-assembling peptide materials to human clinical for treatment of diabetic ulcers, bedsores (pressure ulcers) and for accelerated wound healings as well as surgical uses.[14] Many self-assembling peptide scaffold hydrogel products have received approvals from the US FDA, European Medicine Agency (EMA), Japan Medical Agency and medical approval agency in Chengdu, China.[15]

QTY Code

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Less widely-known, Zhang invented the QTY Code as a systematic method of rendering insoluble peptide sequences water-soluble, to facilitate biochemical research, while retaining the native conformation and functionality.[16][17][18][19] In 2011, Shuguang Zhang started to design membrane proteins, because there are ~26% of genes that code for membrane proteins in genomes which are crucial for both internal and external cellular communications.[20][21] He conceived a simple molecular QTY Code, namely Glutamine (Q), Threonine (T) and Tyrosine (Y) to systematically replace the hydrophobic amino acids Leucine (L), Valine (V), Isoleucine (I), and Phenylalanine (F) in the 7 transmembrane alpha-helices of G protein-coupled receptors (GPCRs).[16][18] Thus, it changes the water-insoluble form of membrane proteins, including GPCRs, into a water-soluble form. The QTY code results suggest that despite 46%-56% transmembrane alpha-helices changes, water-soluble QTY variants still maintain stable structures and biological function, namely, ligand-binding activities. This simple QTY code is a likely useful tool and has big impact for designs of water-soluble variants of previously water-insoluble and perhaps aggregated proteins, including amyloids.[16]

Fellowships and awards

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  • American Cancer Society Postdoctoral Fellow
  • Whitaker Foundation Investigator, MIT
  • 2006 Guggenheim Fellowship[22]
  • Academic sabbatical at University of Cambridge[23]
  • 2006 Wilhelm Exner Medal of Austria[24]
  • Elected to Austrian Academy of Sciences, 2010[25]
  • Elected to American Institute of Medical and Biological Engineering, 2011[26]
  • Elected to US National Academy of Inventors, 2013[27]
  • 2020 Emil Thomas Kaiser Award from the Protein Society[28]
  • Elected to European Academy of Science and Arts, 2021[29]
  • Elected honorary fellow, Erwin Schrödinger Society at the Austrian Academy of Sciences, 2021[30]

References

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  1. ^ "Shuguang Zhang, MIT Media Lab, People". MIT Media Lab.
  2. ^ "Shuguang Zhang". scholar.google.com.
  3. ^ "ORCiD Shuguang Zhang".
  4. ^ Baas, Jeroen (2020). "Bibliometrics". Mendeley Data. Vol. 2. Mendeley. doi:10.17632/btchxktzyw.2.
  5. ^ "Molecular Frontiers Board of Directors".
  6. ^ "Molecular Frontiers Symposia".
  7. ^ "Molecular Frontiers Inquiry Prize".
  8. ^ Zhang, Shuguang (October 20, 2017). "Discovery and design of self-assembling peptides". Interface Focus. 7 (6): 20170028. doi:10.1098/rsfs.2017.0028. PMC 5665798. PMID 29147558.
  9. ^ Zhang, Shuguang (October 11, 1992). "Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae". The EMBO Journal. 11 (10): 3787–3796. doi:10.1002/j.1460-2075.1992.tb05464.x. PMC 556839. PMID 1396572.
  10. ^ "John Simon Guggenheim Foundation - Shuguang Zhang".
  11. ^ Levin, Aviad (September 15, 2020). "Biomimetic peptide self-assembly for functional materials". Nature Reviews Chemistry. 4 (11): 615–634. doi:10.1038/s41570-020-0215-y. PMC 7617017. S2CID 221718855.
  12. ^ Gelain, Fabrizio (February 17, 2021). "Self-assembling peptide scaffolds in the clinic". npj Regenerative Medicine. 6 (1): 9. doi:10.1038/s41536-020-00116-w. PMC 7889856. PMID 33597509.
  13. ^ Yang, Jia (2021). "Self-Assembled Peptide Drug Delivery Systems". ACS Appl. Bio Mater. 4 (1): 24–46. doi:10.1021/acsabm.0c00707. PMID 35014275. S2CID 225639201.
  14. ^ "About - 3-D Matrix".
  15. ^ Gelain, Fabrizio; Luo, Zhongli; Rioult, Marika; Zhang, Shuguang (17 February 2021). "Self-assembling peptide scaffolds in the clinic". npj Regenerative Medicine. 6 (1): 9. doi:10.1038/s41536-020-00116-w. PMC 7889856. PMID 33597509. S2CID 231948060.
  16. ^ a b c Zhang, Shuguang (September 11, 2018). "QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities". Proc. Natl. Acad. Sci. USA. 115 (37): E8652–E8659. Bibcode:2018PNAS..115E8652Z. doi:10.1073/pnas.1811031115. PMC 6140526. PMID 30154163.
  17. ^ Qing, Rui (December 17, 2019). "QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity". Proc. Natl. Acad. Sci. USA. 116 (51): 25668–25676. Bibcode:2019PNAS..11625668Q. doi:10.1073/pnas.1909026116. PMC 6926000. PMID 31776256.
  18. ^ a b Arnaud, Celia (August 29, 2018). "Following a code for swapping amino acids makes membrane proteins water soluble". Chemical & Engineering News. 96.
  19. ^ Trafton, Anne (August 28, 2018). "Scientists alter membrane proteins to make them easier to study". Phys.org.
  20. ^ Fagerberg, Linn; Jonasson, Kalle; Von Heijne, Gunnar; Uhlén, Mathias; Berglund, Lisa (19 March 2010). "Prediction of the human membrane proteome". Proteomics. 10 (6): 1141–1149. doi:10.1002/pmic.200900258. PMID 20175080. S2CID 5082887.
  21. ^ Wallin, Erik; Von Heijne, Gunnar (31 December 2008). "Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms". Protein Science. 7 (4): 1029–1038. doi:10.1002/pro.5560070420. PMC 2143985. PMID 9568909.
  22. ^ "John Simon Guggenheim Foundation - Shuguang Zhang".
  23. ^ "Cambridge vs. Cambridge: a personal comparison - News Article on Nature Network Boston" (PDF).
  24. ^ "Shuguang Zhang - Wilheim Exner Medaillen Stiftung".
  25. ^ "ÖAW Mitglieder Detail".
  26. ^ "Shuguang Zhang, Ph.D. COF-1267 - AIMBE".
  27. ^ "National Academy of Inventors".
  28. ^ "Shuguang Zhang receives Emil Thomas Kaiser Award – MIT Media Lab".
  29. ^ "Members - European Academy of Sciences and Arts".
  30. ^ "flyer-20th-colloquium.pdf" (PDF).

Further reading

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