MYCL

MYCL
Identifiers
Aliases	MYCL, LMYC, MYCL1, bHLHe38, L-Myc, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, MYCL proto-oncogene, bHLH transcription factor
External IDs	OMIM: 164850; MGI: 96799; HomoloGene: 3921; GeneCards: MYCL; OMA:MYCL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,902,256 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	122,896,278 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of leg; ; epithelium of esophagus; ; skin of abdomen; ; skin of thigh; ; granulocyte; ; body of pancreas; ; mucosa of urinary bladder; ; gonad; ; gums;
	Top expressed in
	transitional epithelium of urinary bladder; ; corneal stroma; ; hair follicle; ; ventricular zone; ; ganglionic eminence; ; tail of embryo; ; white matter of cerebellum; ; genital tubercle; ; lip; ; medial ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein dimerization activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; regulation of inner ear auditory receptor cell differentiation; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4610
	16918
	ENSG00000116990
	ENSMUSG00000028654
	P12524
	P10166
	NM_005376; NM_001033081; NM_001033082
	NM_008506; NM_001303121
	NP_001028253; NP_001028254; NP_005367
	NP_001290050; NP_032532
	Wikidata
View/Edit Human	View/Edit Mouse

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.^[5]^[6]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.^[7]

Interactions

MYCL1 has been shown to interact with MAX.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116990 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028654 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.
^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC 401025. PMID 2548855.
^ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–1217. Bibcode:1991Sci...251.1211B. doi:10.1126/science.2006410. PMID 2006410.
^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.

Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341.
Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC 401025. PMID 2548855.
Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. doi:10.1128/mcb.8.1.186. PMC 363100. PMID 2827002.
De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. doi:10.1128/mcb.8.10.4381. PMC 365511. PMID 3054516.
DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. doi:10.1101/gad.1.10.1311. PMID 3322939.
Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. Bibcode:1995PNAS...9210217A. doi:10.1073/pnas.92.22.10217. PMC 40767. PMID 7479755.
FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.
Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. doi:10.1111/j.1349-7006.2002.tb01193.x. PMC 5926866. PMID 11802801.
Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. doi:10.3892/or.9.2.345. PMID 11836605.
Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. doi:10.3892/or.9.3.551. PMID 11956626.
Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. doi:10.1111/j.1582-4934.2002.tb00188.x. PMC 6740283. PMID 12169206.
Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. doi:10.1016/S0002-9440(10)64294-0. PMC 1851191. PMID 12707044.
Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. doi:10.1158/1078-0432.CCR-0779-3. PMID 15014029.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer. 55 (3): 271–277. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094.

External links

MYCL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116990 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028654 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978772-5] Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.

[entrez-6] "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".

[7] Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC 401025. PMID 2548855.

[pmid2006410-8] Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–1217. Bibcode:1991Sci...251.1211B. doi:10.1126/science.2006410. PMID 2006410.

[pmid10229200-9] FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.

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Interactions

References

Further reading

External links