Louise Rollins-Smith
 | This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. (January 2025) |
Louise Rollins-Smith | |
|---|---|
| Nationality | American |
| Alma mater | Hamline University, University of Minnesota |
| Scientific career | |
| Fields | Immunology, Amphibians, Antimicrobial peptides |
| Institutions | Vanderbilt University |
| Thesis | (1977) |
Louise Rollins-Smith is a professor of biological sciences, professor of pediatrics, and a professor of pathology, microbiology and immunology at Vanderbilt University. She is known for her work investigating host-pathogen interactions using amphibians as model organisms.
Education and career
[edit]Rollins-Smith received her Bachelor's degree in Biology at Hamline University, Saint Paul, Minnesota, before completing a Masters and a Ph.D. in zoology at the University of Minnesota in 1977.[1] Rollins-Smith was a postdoctoral researcher at the University of Rochester before joining Vanderbilt University in 1984.[2]
Research
[edit]Rollins-Smith has studied disease and immunity in amphibians. Her early research was focused upon Lucké renal adenocarcinoma of leopard frogs,[3][4] the development of immunological tolerance and immune changes at metamorphosis in frogs.[5] Rollins-Smith has also studied the effects of immunotoxic and agricultural chemicals on amphibian immunity.[6][7] Rollins-Smith's research has examined the link between widespread amphibian declines and the amphibian chytrid fungi, Bactrochochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal),[8] particularly in relation to amphibian immunity.[9][10] Rollins-Smith has also become known for her work on amphibian skin antimicrobial peptides (AMPs). Alongside her colleagues, she has provided evidence that the effectiveness of AMPs is a valuable predictor of amphibian species susceptibility to the Bd,[11] and that AMPs are potent inhibitors of viral infection, including HIV infection of human T lymphocytes.[12]
Selected publications
[edit]- Carey, Cynthia; Cohen, Nicholas; Rollins-Smith, Louise (1999-09-01). "Amphibian declines: an immunological perspective". Developmental & Comparative Immunology. 23 (6): 459–472. doi:10.1016/S0145-305X(99)00028-2. ISSN 0145-305X. PMID 10512457.
- Rollins-Smith, Louise A. (1998). "Metamorphosis and the amphibian immune system". Immunological Reviews. 166 (1): 221–230. doi:10.1111/j.1600-065X.1998.tb01265.x. ISSN 1600-065X. PMID 9914915.
- Woodhams, D. C.; Ardipradja, K.; Alford, R. A.; Marantelli, G.; Reinert, L. K.; Rollins-Smith, L. A. (2007). "Resistance to chytridiomycosis varies among amphibian species and is correlated with skin peptide defenses". Animal Conservation. 10 (4): 409–417. Bibcode:2007AnCon..10..409W. doi:10.1111/j.1469-1795.2007.00130.x. ISSN 1367-9430.
- Rollins-Smith, Louise A. (2009-08-01). "The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788 (8): 1593–1599. doi:10.1016/j.bbamem.2009.03.008. ISSN 0005-2736. PMID 19327341.
- Ramsey, Jeremy P.; Reinert, Laura K.; Harper, Laura K.; Woodhams, Douglas C.; Rollins-Smith, Louise A. (2010). "Immune Defenses against Batrachochytrium dendrobatidis, a Fungus Linked to Global Amphibian Declines, in the South African Clawed Frog, Xenopus laevis". Infection and Immunity. 78 (9): 3981–3992. doi:10.1128/iai.00402-10. PMC 2937463. PMID 20584973.
References
[edit]- ^ "Vanderbilt University School of Medicine". wag.app.vanderbilt.edu. Retrieved 2023-12-12.
- ^ "Rollins-Smith Lab Members | The Rollins-Smith Lab". www.vumc.org. Retrieved 2023-12-12.
- ^ Rollins-Smith, Louise A.; Cohen, Nicholas (September 1984). "Effect of Thyroxine on Induction of Lucké Renal Adenocarcinomas in Lucké Tumor Herpesvirus-Infected Leopard Frog Tadpoles2". JNCI: Journal of the National Cancer Institute. 73 (3): 717–720. doi:10.1093/jnci/73.3.717. ISSN 1460-2105. PMID 6332231.
- ^ Rollins-Smith, Louise A.; Cohen, Nicholas (January 1982). "Effect of Thymectomy on Development of Lucké Renal Adenocarcinomas in Virus-Infected Leopard Frog Tadpoles23". JNCI: Journal of the National Cancer Institute. 68 (1): 133–138. doi:10.1093/jnci/68.1.133. ISSN 1460-2105.
- ^ Rollins-Smith, Louise A.; Blair, Patrick J.; Davis, A. Tray (1992). "Thymus Ontogeny in Frogs: T-Cell Renewal at Metamorphosis". Journal of Immunology Research. 2 (3): 207–213. doi:10.1155/1992/26251. ISSN 2314-8861. PMC 2275863. PMID 1320967.
- ^ Rollins-Smith, Louise A.; Hopkins, B. Diane (1997-03-01). "F2 2:00 Immunotoxic effects of diazinon and lead on the developing hematopoietic system of Xenopus laevis". Developmental & Comparative Immunology. The 7th Congress of The International Society of Developmental and Comparative Immunology. 21 (2): 121. doi:10.1016/S0145-305X(97)88572-2. ISSN 0145-305X.
- ^ Christin, M. S.; Ménard, L.; Gendron, A. D.; Ruby, S.; Cyr, D.; Marcogliese, D. J.; Rollins-Smith, L.; Fournier, M. (2004-03-30). "Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens". Aquatic Toxicology. 67 (1): 33–43. Bibcode:2004AqTox..67...33C. doi:10.1016/j.aquatox.2003.11.007. ISSN 0166-445X. PMID 15019249.
- ^ "Amphibian population on the decline". Stewart-Houston Times. 1998-10-27. p. 15. Retrieved 2025-01-07.
- ^ Brown, Josh (2014-07-14). "Scientists find new weapon to fight deadly frog virus". The Tennessean. pp. A13. Retrieved 2025-01-07.
- ^ Phelan, Meagan (17 October 2013). "Fatal Frog Fungus Maneuvers Past Immune System". American Association for the Advancement of Science (AAAS). Retrieved 2025-01-07.
- ^ Rollins-Smith, Louise A.; Doersam, Jennifer K.; Longcore, Joyce E.; Taylor, Sharon K.; Shamblin, Jessica C.; Carey, Cynthia; Zasloff, Michael A. (2002-01-01). "Antimicrobial peptide defenses against pathogens associated with global amphibian declines". Developmental & Comparative Immunology. 26 (1): 63–72. doi:10.1016/S0145-305X(01)00041-6. ISSN 0145-305X. PMID 11687264.
- ^ Pinto, Claudia (2005-10-21). "Frog secretions block HIV infections, VU study finds". The Tennessean. pp. A1, [1]. Retrieved 2025-01-07.
External links
[edit]- Louise Rollins-Smith publications indexed by Google Scholar
- Rollins-Smith Lab
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