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John Constantino

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John Constantino
Occupation(s)Inaugural System Chief of Behavioral and Mental Health
AwardsGeorge Tarjan Award, American Academy of Child and Adolescent Psychiatry, 2015
Academic background
Alma materCornell University; Washington University School of Medicine
Academic work
InstitutionsChildren's Healthcare of Atlanta

John N. Constantino is a child psychiatrist and expert on neurodevelopmental disorders, especially autism spectrum disorders (ASD).[1] Constantino is the inaugural System Chief of Behavioral and Mental Health at Children's Healthcare of Atlanta. He is a Professor of Pediatrics, Psychiatry and Behavioral Sciences and Genetics at the Emory University School of Medicine.

Constantino is best known for developing the Social Responsiveness Scale (SRS),[2] a diagnostic rating scale used to distinguish autism spectrum disorder from other child psychiatric conditions by identifying the presence and extent of social impairments.[3] The SRS, published in 2005, includes parent-, teacher-, self-, and spouse-report rating forms. It has been used to assess social-behavioral characteristics indicative of the broader autism phenotype.[4] The SRS is a widely used tool to help clinicians identify social impairments in individuals both with and without a diagnosis of ASD.

Constantino received the 2014 Irving Philips Award and the 2015 George Tarjan Award from the American Academy of Child and Adolescent Psychiatry,[5] respectively for lifetime contributions in prevention and developmental disabilities. In 2013, he received the Alumni Achievement Award from the Washington University School of Medicine.[6]

Biography

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Constantino earned his B.A. at Cornell University in 1984. Constantino completed his medical degree at Washington University School of Medicine in 1988. After completing a 5-year combined residency in pediatrics, general psychiatry and child psychiatry at the Albert Einstein School of Medicine, Constantino joined the faculty of Washington University School of Medicine where he held the appointment of the Blanche F. Ittelson Chair and Chief of the Division of Child and Adolescent Psychiatry from 2009 to 2022 and co-led its Intellectual and Developmental Disabilities Research Center (IDDRC). His research program at the IDDRC was funded through numerous grants from the National Institutes of Health. [7]

Constantino was appointed the Liz and Frank Blake Chair of Behavioral and Mental Health at Children's Healthcare of Atlanta in 2024, following his move to Atlanta in 2022 to lead a large-scale effort to model system transformation and parity in child mental health there and at Emory University.[8]

Research

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Constantino's research program focuses on developmental disabilities and social development from infancy through early adulthood.[9]  Some of his most influential work has used twin studies to examine the prevalence of autistic traits in the general population (also referred to as the broader autism phenotype[10]) and in at-risk groups including individuals with attention deficit hyperactivity disorder who have heightened rates of autistic traits.[11]

As a member of the Autism Genome Project Consortium,[12] Constantino was involved in genetic linkage studies of autism risk.[13] His laboratory linked familial risk for autism to early variations in visual social engagement,[14] motor coordination[15] and activity level.[16] Other research has examined patterns of familial aggregation in multiplex autism, defined as instances where two or more individuals in the same family are affected; knowledge gained from these studies helped specify the impact of combined influences of independently-inherited traits on early childhood social development[17][18] His work has also elucidated opportunities to resolve enduring disparities in developmental outcomes of minority children affected by autism.[19] His research contributions have also addressed environmental influences on antisocial development[20] including prospects for its prevention through parenting education[21] and the prevention of maltreatment in early childhood.[22]

Representative publications

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  • Constantino, J. N., Zhang, Y. I., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. American Journal of Psychiatry, 167(11), 1349–1356.
  • Constantino JN, Gruber CP (2012) The Social Responsiveness Scale Manual, Second Edition (SRS-2). Los Angeles, CA: Western Psychological Services.
  • Constantino JN. Prevention of child maltreatment: strategic targeting of a curvilinear relationship between adversity and psychiatric impairment. World Psychiatry. 2018 Feb;17(1):103-104. doi: 10.1002/wps.20495. PMID: 29352551; PMCID: PMC5775142.
  • Constantino JN. Early behavioral indices of inherited liability to autism. Pediatr Res. 2019 Jan;85(2):127-133. doi: 10.1038/s41390-018-0217-3. Epub 2018 Oct 24. PMID: 30356093; PMCID: PMC6353672.
  • Constantino JN, Charman T, Jones EJH. Clinical and Translational Implications of an Emerging Developmental Substructure for Autism. Annu Rev Clin Psychol. 2021 May 7;17:365-389 Broder-Fingert S, Mateo CM, Zuckerman KE. Structural Racism and Autism. Pediatrics. 2020 Sep;146(3):e2020015420.

References

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  1. ^ "John Constantino". scholar.google.com. Retrieved 2024-09-02.
  2. ^ "(SRS™-2) Social Responsiveness Scale, Second Edition". www.wpspublish.com. Retrieved 2024-09-02.
  3. ^ Wagner, Rachael E.; Zhang, Yi; Gray, Teddi; Abbacchi, Anna; Cormier, Deporres; Todorov, Alexandre; Constantino, John N. (2019). "Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study". Child Development. 90 (2): 441–451. doi:10.1111/cdev.13170. ISSN 0009-3920. PMC 6446804. PMID 30346626.
  4. ^ Zeliadt, Nicholette; Spectrum (2016-11-14). "What Grandmothers Can Teach Science About Autism". The Atlantic. Retrieved 2024-09-02.
  5. ^ Dryden, Jim (2014-11-04). "Constantino receives Phillips award". The Source. Retrieved 2024-09-02.
  6. ^ "John N. Constantino, MD". Washington University School of Medicine in St. Louis. Retrieved 2024-09-02.
  7. ^ Brian (2015-11-23). "$6.5 million to fund research, treatment of developmental disabilities". Washington University School of Medicine in St. Louis. Retrieved 2024-09-02.
  8. ^ Constantino, John N. (2023). "Bridging the Divide Between Health and Mental Health: New Opportunity for Parity in Childhood". Journal of the American Academy of Child and Adolescent Psychiatry. 62 (11): 1182–1184. doi:10.1016/j.jaac.2023.03.019. ISSN 1527-5418. PMID 37230286.
  9. ^ Constantino, John N. (2011). "The quantitative nature of autistic social impairment". Pediatric Research. 69 (5 Pt 2): 55R – 62R. doi:10.1203/PDR.0b013e318212ec6e. ISSN 1530-0447. PMC 3086844. PMID 21289537.
  10. ^ Constantino, John N.; Todd, Richard D. (2003-05-01). "Autistic Traits in the General Population: A Twin Study". Archives of General Psychiatry. 60 (5): 524. doi:10.1001/archpsyc.60.5.524. ISSN 0003-990X.
  11. ^ Reiersen, Angela M.; Constantino, John N.; Volk, Heather E.; Todd, Richard D. (2007). "Autistic traits in a population-based ADHD twin sample". Journal of Child Psychology and Psychiatry. 48 (5): 464–472. doi:10.1111/j.1469-7610.2006.01720.x. ISSN 0021-9630. PMID 17501727.
  12. ^ "dbGaP Study". www.ncbi.nlm.nih.gov. Retrieved 2024-09-02.
  13. ^ The Autism Genome Project Consortium (2007). "Mapping autism risk loci using genetic linkage and chromosomal rearrangements". Nature Genetics. 39 (3): 319–328. doi:10.1038/ng1985. ISSN 1061-4036. PMC 4867008. PMID 17322880.
  14. ^ Constantino, John N.; Kennon-McGill, Stefanie; Weichselbaum, Claire; Marrus, Natasha; Haider, Alyzeh; Glowinski, Anne L.; Gillespie, Scott; Klaiman, Cheryl; Klin, Ami; Jones, Warren (2017). "Infant viewing of social scenes is under genetic control and is atypical in autism". Nature. 547 (7663): 340–344. doi:10.1038/nature22999. ISSN 0028-0836. PMC 5842695. PMID 28700580.
  15. ^ Mous, Sabine E.; Jiang, Allan; Agrawal, Arpana; Constantino, John N. (2017). "Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings". Journal of Neurodevelopmental Disorders. 9 (1): 32. doi:10.1186/s11689-017-9212-y. ISSN 1866-1947. PMC 5583755. PMID 28870164.
  16. ^ Pohl, Alexa; Jones, Warren R.; Marrus, Natasha; Zhang, Yi; Klin, Ami; Constantino, John N. (2019-08-22). "Behavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability". Translational Psychiatry. 9 (1): 202. doi:10.1038/s41398-019-0545-z. ISSN 2158-3188. PMC 6706410. PMID 31439834.
  17. ^ Virkud, Yamini V.; Todd, Richard D.; Abbacchi, Anna M.; Zhang, Yi; Constantino, John N. (2009-04-05). "Familial aggregation of quantitative autistic traits in multiplex versus simplex autism". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 150B (3): 328–334. doi:10.1002/ajmg.b.30810. ISSN 1552-4841. PMC 2819431. PMID 18618672.
  18. ^ Constantino, John N. (2018). "Deconstructing autism: from unitary syndrome to contributory developmental endophenotypes". International Review of Psychiatry. 30 (1): 18–24. doi:10.1080/09540261.2018.1433133. ISSN 1369-1627. PMC 5934305. PMID 29498298.
  19. ^ Constantino, John N.; Abbacchi, Anna M.; May, Brandon K.; Klaiman, Cheryl; Zhang, Yi; Lowe, Jennifer K.; Marrus, Natasha; Klin, Ami; Geschwind, Daniel H. (2023). "Prospects for Leveling the Playing Field for Black Children With Autism". Journal of the American Academy of Child & Adolescent Psychiatry. 62 (9): 949–952. doi:10.1016/j.jaac.2023.05.005. PMC 10948275. PMID 37196781.
  20. ^ Jonson-Reid, Melissa; Presnall, Ned; Drake, Brett; Fox, Louis; Bierut, Laura; Reich, Wendy; Kane, Phyllis; Todd, Richard D.; Constantino, John N. (2010). "Effects of child maltreatment and inherited liability on antisocial development: an official records study". Journal of the American Academy of Child and Adolescent Psychiatry. 49 (4): 321–332, quiz 431. ISSN 1527-5418. PMC 2878182. PMID 20410725.
  21. ^ Presnall, Ned; Webster-Stratton, Carolyn H.; Constantino, John N. (2014). "Parent Training: Equivalent Improvement in Externalizing Behavior for Children With and Without Familial Risk". Journal of the American Academy of Child & Adolescent Psychiatry. 53 (8): 879–887.e2. doi:10.1016/j.jaac.2014.04.024. PMC 4492282. PMID 25062595.
  22. ^ Constantino, John N.; Buchanan, Gretchen; Tandon, Mini; Bader, Carol; Jonson-Reid, Melissa (2023-09-01). "Reducing Abuse and Neglect Recurrence Among Young Foster Children Reunified With Their Families". Pediatrics. 152 (3). doi:10.1542/peds.2022-060118. ISSN 0031-4005. PMC 11539087.
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