Jack L. Feldman
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Jack L. Feldman is an American neuroscientist, David Geffen School of Medicine Chair in Neuroscience and Distinguished Professor of Neurobiology at the University of California, Los Angeles (UCLA).[1][2] His research contributions include elucidating the mechanisms underlying breathing and sighing.[3][4][2] He discovered and named the pre-Bötzinger complex,[5] an area in the brain stem that is responsible for controlling breathing. He was the recipient of the Hodgkin–Huxley–Katz Prize[6] from the Physiological Society in 2017.
Early life
[edit]Feldman received his Bachelor's degree in physics from the Polytechnic Institute of NY in 1968, and a PhD in physics from the University of Chicago. His PhD focused breathing and respiratory networks from a theoretical perspective.[7] He went on to perform experimental neuroscience as a postdoc in Paris with Henri Gautier and Andre Hugelin and a second postdoc with Mort Cohen in New York. In 1978, he began his first academic appointment as assistant professor at Northwestern in Chicago, where he went through the ranks to full professor. In 1986, he moved to UCLA, where he is a Distinguished Professor of Neurobiology.[7]
Research
[edit]Feldman's early research focused on locating the central pattern generator responsible for breathing in 1986 identified the pre-Bötzinger complex.[5] The areas was so named because it was located immediately caudal to an area he had previously named the Bötzinger complex[8] in 1978 after a bottle of Bötzinger wine that was being served during dinner. In 2016, he and his collaborators identified a neuropeptide that acts in the pre-Bötzinger complex to govern sighing.[9][10][11] When this neuropeptide was introduced to the pre-Bötzinger complex animals engaged in vigorous respiratory sighing.
Feldman has published over 150 peer-reviewed papers in scientific journals.
Honors
[edit]- Fellow, American Association for the Advancement of Science (2009)
- Hodgkin Huxley Katz Prize, The Physiological Society (2016)[1]
References
[edit]- ^ a b "Jack L. Feldman, Ph.D. | Brain Research Institute". www.bri.ucla.edu. Retrieved 2020-01-19.
- ^ a b "Jack L. Feldman Ph.D. | Neurobiology Department at UCLA". www.neurobio.ucla.edu. Retrieved 2020-01-19.
- ^ "BBC World Service - Newsday, How the brain's sighing reflex was named". BBC. 9 February 2016. Retrieved 2020-01-19.
- ^ "Scientists Uncover the Brain Mechanisms that Makes you Sigh". The Washington Post.
- ^ a b Smith, J. C.; Ellenberger, H. H.; Ballanyi, K.; Richter, D. W.; Feldman, J. L. (1991-11-01). "Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals". Science. 254 (5032): 726–729. Bibcode:1991Sci...254..726S. doi:10.1126/science.1683005. ISSN 0036-8075. PMC 3209964. PMID 1683005.
- ^ "Hodgkin-Huxley-Katz Prize Lecture".
- ^ a b Grillner, Sten (2011-01-01), Gossard, Jean Pierre; Dubuc, Réjean; Kolta, Arlette (eds.), "Chapter 13 - On walking, chewing, and breathing—A tribute to Serge, Jim, and Jack", Progress in Brain Research, Breathe, Walk and Chew: The Neural Challenge: Part II, 188, Elsevier: 199–211, doi:10.1016/B978-0-444-53825-3.00018-8, ISBN 9780444538253, PMID 21333811, retrieved 2020-01-19
- ^ Control of Ventilation. Medical physiology: a cellular and molecular approach (2nd ed., International ed.). Philadelphia, PA: Saunders/Elsevier. 2009.
- ^ Feltman, Rachel (2016-02-08). "Scientists uncover the brain mechanism that makes you sigh". Washington Post. Retrieved 2020-01-19.
- ^ Breathing Matters, retrieved 2020-01-19
- ^ Li, Peng; Janczewski, Wiktor A.; Yackle, Kevin; Kam, Kaiwen; Pagliardini, Silvia; Krasnow, Mark A.; Feldman, Jack L. (February 2016). "The peptidergic control circuit for sighing". Nature. 530 (7590): 293–297. Bibcode:2016Natur.530..293L. doi:10.1038/nature16964. ISSN 1476-4687. PMC 4852886. PMID 26855425.
