File:The Meyer-Overton Correlation (Final).png
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Summary
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English: The Meyer-Overton Correlation for Anesthetics. This principle states that the potency of general anesthetic agents is directly correlated to lipid solubility. [X-axis] The more soluble the agent is, the more potent the anesthetic effect. This concept also applies to the therapeutic index (TI) of the drug, with more potent agents presenting a lower TI. [Y-axis] This diagram is a modified representation of only gaseous (inhalable) anesthetic agents based on the minimal alveolar concentration (MAC). However, most intravenous anesthetic agents maintain the same correlation based upon the effective dose 50% (ED50). [Origin] This correlation is named after Hans Horst Meyer and Charles Ernest Overton, who independently discovered and published about the same phenomena in 1899 and 1901, respectively. The original Meyer-Overton Correlation graph compared the anesthetic partition coefficient in olive oil (X-axis) to the effective dose that induced general anesthesia in tadpoles (Y-axis). This graph is an updated representation based on modern measures and methods of general anesthesia. |
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| Author | NeuroImagem |
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| current | 01:04, 26 November 2024 | | 2,338 × 1,996 (512 KB) | NeuroImagem | Uploaded own work with UploadWizard |
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