Dynein, axonemal, heavy chain 14

DNAH14
Identifiers
Aliases	DNAH14, C1orf67, Dnahc14, HL-18, HL18, dynein axonemal heavy chain 14
External IDs	OMIM: 603341; MGI: 2444525; HomoloGene: 90078; GeneCards: DNAH14; OMA:DNAH14 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,399,292 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	181,643,339 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; body of pancreas; ; testicle; ; anterior pituitary; ; gonad; ; buccal mucosa cell; ; islet of Langerhans; ; ventricular zone; ; epithelium of colon;
	Top expressed in
	spermatocyte; ; testicle; ; bone marrow; ; spermatid; ; zygote; ; secondary oocyte; ; granulocyte; ; thymus; ; primary oocyte; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; cytoskeletal motor activity; ATP binding; minus-end-directed microtubule motor activity; dynein light chain binding; dynein intermediate chain binding; dynein light intermediate chain binding;
Cellular component	cytoplasm; cell projection; microtubule; cytoskeleton; cilium; dynein complex;
Biological process	microtubule-based movement; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	127602
	240960
	ENSG00000185842
	ENSMUSG00000047369
	Q0VDD8
	n/a
NM_001145154; NM_001373; NM_144989; NM_001349911; NM_001349912;
	NM_001367479; NM_001367481
	NM_172846; NM_001377039
NP_001138626; NP_659426; NP_001336840; NP_001336841; NP_001354408;
	NP_001354410
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene.^[5]

Function

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185842 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047369 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Dynein, axonemal, heavy chain 14".
^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185842 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047369 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dynein, axonemal, heavy chain 14".

[6] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

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