Draft:Vladimir Dadali

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Vladimir Dadali (born December 18, 1937, Mykolaiv, Mykolaiv Oblast, Ukrainian SSR, USSR) is a biochemist, Doctor of Chemical Sciences, Professor of the Department of Biological and General Chemistry of the North-Western State Medical University named after I.I. Mechnikov. He was involved in the development and implementation of natural medicinal products (raunatin, novoaekol). Currently, he is developing recipes for natural compositions related to dietary supplements.

Biography

Vladimir Dadali was born into the family of a military serviceman. He graduated with honors from the Pharmaceutical Faculty of the First Moscow State Medical Institute (now university) named after I.M. Sechenov in 1960 and then from the Chemistry Faculty of Kharkiv State University.

He worked as a research associate at the Kharkiv Research Chemical and Pharmaceutical Institute, where he co-authored the development of the drug "Raunatin", and then at the Department of Chemical Kinetics of Kharkiv State University.

Scientific career

In 1986, he defended his Doctorate dissertation on the topic "The Mechanism of Catalysis and Structural Effects in a Series of Imidazoles" at the Physical Chemistry Council of Moscow State University named after Lomonosov.

The scientific interests of Professor Dadali are diverse. In 2002 the research "Biologically Active Supplements in the Treatment of Patients with Cardiovascular Pathology" was conducted by Vladimir Dadali and his colleagues Baskovich and Stolpnik. With the active support of Professor V. A. Dadali, a regional (innovative) center "Adaptogen" was created.

Since 2002 Professor Dadali has been studying Transfer Factors and their potential use in supporting human immunity. That year he conducted the research on the topic "Application of Transfer Factor on Patients with Osteomyelitis" . Later, in 2011 took part in the research "Study Of Adaptogenic And Antioxidant Properties Of The Dietary Supplement "Transfer Factor Advanced", where new properties of Transfer Factors were found and proved.

Patents

• Method for treating patients with allergic rhinitis
• Water-soluble molecular inclusion complex of reduced form of coenzyme Q10 in β-cyclodextrin and a method for its preparative production
• Express method for obtaining the reduced form of coenzyme Q10 based on catalysts for use in pharmaceutical and food compositions

Public lectures

Professor Dadali's channel on Youtube

Notes

• For example, the video "4Life: Partnering with Professor Dadali". Video published on August 29, 2024. Accessed on September 1, 2024.
• Vidal's Drug Directory "Raunatin" Archived March 13, 2023, at the Wayback Machine.
• Patents — Interregional Center "Adaptogen" Archived March 16, 2023, at the Wayback Machine. Country — Russia (RU), number of patents — 7, received — 1999-2000, team of authors — 13 people.
• From №2373968. Accessed: March 14, 2023. Archived March 14, 2023.
• From №2509760. Date of access: March 14, 2023. Archived March 14, 2023.
• From №2535928. Accessed: March 14, 2023. Archived March 14, 2023.

Scientific Work

Dadali VA, Svidovyĭ VI, Makarov VG, Gor'kova LB, Kuleva VA, Pavlova RN, Tarasova OV, Timofeeva VM. Deĭstvie infrazvuka i zashchitnyĭ éffekt adaptogenov v éksperimente [Effects of infrasound and protective effect of adaptogens in experimental animals]. Gig Sanit. 1992 Jan;(1):40-3. Russian. PMID: 1526491.

Dadali VA, Golovanova NE, Pavlova RN, Dzhangulova NE, Vinogradova VE. Corrective effect of clotrimazole and beta-ionol during exposure to thiophenol. Bull Exp Biol Med. 2000 Nov;130(11):1090-2. PMID: 11182824.

KOLESNIKOV DG, PROKOPENKO AP, CHERNOBAI VT, DADALI VA. [Production of Raunatin from Rauwolfia serpentina roots]. Med Prom SSSR. 1961 Dec;12:25-7. Russian. PMID: 14457978.

Maĭmulov VG, Baskovich GA, Dadali VA. Metodologicheskie aspekty biokhimicheskikh issledovaniĭ adaptatsionnogo statusa organizma [Methodologic aspects of biochemical research on the adaptational status in the human body]. Gig Sanit. 1993 Oct;(10):61-3. Russian. PMID: 8163240.

Pavlova RN, Kuznetsova OA, Dadali VA, Abyshev AZ, Sokolova EA. Zavisimost' antioksidantnogo deĭstviia proizvodnykh imidazola ot kontsentratsii i sposoba vvedeniia [Dependence of the antioxidant effect of imidazole derivatives on concentration and a method of administration]. Eksp Klin Farmakol. 2001 May-Jun;64(3):50-2. Russian. PMID: 11558440.

Pavlova RN, Kariakina LA, Beĭshebaeva ChR, Dadali VA. [The utilization of omegalicin in treatment of psoriasis]. Klin Lab Diagn. 2011 Jul;(7):17-20. Russian. PMID: 21899112.

Krivolesova SA, Svidovyĭ VI, Lobov GI, Dadali VA. Deĭstvie infrazvuka i shuma na sokratitel'nuiu aktivnost' limfaticheskikh sosudov (éksperimental'noe issledovanie) [Effects of infrasound and noise on contractility of lymphatic vessels (an experimental study)]. Med Tr Prom Ekol. 2001;(2):16-20. Russian. PMID: 11270145.

Dadali VA, Makarov VG. Biologicheski aktivnye veshchestva lekarstvennykh rasteniĭ kak faktor detoksikatsii organizma [Biologically active substances from medicinal plants as a factor of the organism detoxication]. Vopr Pitan. 2003;72(5):49-55. Russian. PMID: 14619618.

Dadali VA, Tutel'ian VA, Dadali IuV, Kravchenko LV. [Carotenoids. Bioavailability, biotransformation, antioxidant properties]. Vopr Pitan. 2010;79(2):4-18. Russian. PMID: 20560478.

Dubinina EE, Dadali VA. Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry (Mosc). 2010 Sep;75(9):1069-87. doi: 10.1134/s0006297910090014. PMID: 21077827.

Dadali VA, Tutel'ian VA, Dadali IuV, Kravchenko LV. [Carotenoids. Biological activities]. Vopr Pitan. 2011;80(4):4-18. Russian. PMID: 22232877.

References

• Dadali V.A., Rak A.V., Stolpnik E.S., McCausland K., Oganova E.A. 2002. Применение Трансфер Фактора в лечении больных остеомиелитом. [Application Of Transfer Factor In The Treatment Of Patients With Osteomyelitis.] Bulletin of the I.I. Mechnikov St. Petersburg State Medical Academy. No. 3-4. P. 48.
• Dadali V.A., Baskovich G.A., Stolpnik E.S. 2002. Биологически Активные Добавки В Лечении Больных С Сердечно-сосудистой Патологией. [Biologically Active Supplements in the Treatment of Patients with Cardiovascular Pathology]. Bulletin of the St. Petersburg State Medical Academy named after I.I. Mechnikov. No. 1-2. P. 101
• Dadali V.A., Pavlova R.N., Golovanova N.E., Smertina M.N., Kuleba V.A., Agafonova O.A., Beishebaeva Ch.R. 2011. Исследование Адаптогенных И Антиоксидантных Свойств Бад "Трансфер Фактора Эдвэнсд. [Study Of Adaptogenic And Antioxidant Properties Of The Dietary Supplement "Transfer Factor Advanced"]. Problems of biological, medical and pharmaceutical chemistry. Vol. 9. No. 11. P. 64-70.
• Department of Biological and General Chemistry named after V. V. Sokolovsky. (n.d.). North-Western State Medical University named after I. I. Mechnikov.
• Две знаменательные даты отметил д.хим.н. профессор Владимир Абдулаевич Дадали: 75 лет со дня рождения и 25 лет руководства кафедрой биохимии. Поздравляем! Вестник Санкт-Петербургской государственной медицинской академии им. [Two significant dates were celebrated by Dr. of Chemical Sciences, Professor Vladimir Abdulayevich Dadali: 75 years since his birthday and 25 years of leading the Department of Biochemistry. Congratulations! Bulletin of the North-Western State Medical University], × 1 ×(15), 6.
• Владимиру Абдулаевичу Дадали, доктору химических наук, профессору кафедры биологической и общей химии им. В. В. Соколовского, исполнилось 85 лет! Поздравляем! [Vladimir Abdulayevich Dadali, Doctor of Chemical Sciences, Professor of the Department of Biological and General Chemistry named after V.V. Sokolovsky, on his 85th birthday! Congratulations!] Bulletin of the North-Western State Medical University, × 11 ×(125), 6.
• Makarov, V. G., Ryzhenkov, V. E., Dadali, V. A., et al. (2000). Результаты изучения биологической активности нового препарата Ликол // Вопросы биологии, медицины и фармацевтической химии. ["Results of studying the biological activity of the new drug Lykol". Questions of Biology, Medicine, and Pharmaceutical Chemistry], × 1 ×, 47–50.
• Makarov, V. G., Ryzhenkov, V. E., Fedotova, Yu. O., & Shikov, A. N. (2004). Действие полифенольного препарата ликол на центральную нервную систему. [The effect of the polyphenol drug lykol on the central nervous system. ]Psychopharmacology and Biological Narcology, × 1 ×, 601–607.
• Shabrov, A.V., Dadali, V. A., & Makarov, V. G. (2003). Биохимические основы действия микрокомпонентов пищи. [Biochemical basis of the action of microcomponents of food ] (Ed. V. A. Dadali). Avvaloon.
• Dadali, V. A., & Tutelyan, V. A. (2007). Фитостерины - биологическая активность и перспективы практического применения // Успехи современной биологии ["Phytosterols: Biological activity and prospects for practical application". Advances in Modern Biology], × 127 ×(5), 458–470.
• Dadali, V. A., Tutelyan, V. A., Dadali, Yu. V., & Kravchenko, L. V. (2011). Каротиноиды. Биологическая активность // Вопросы питания. ["Carotenoids: Biological activity". Issues of Nutrition], × 80 ×(4), 4–16.
• Dadali, V. A., Tutelyan, V. A., Dadali, Yu. V., & Kravchenko, L. V. (2010). Каротиноиды. Строение и свойства // Вопросы питания ["Carotenoids: Structure and properties". Issues of Nutrition], × 79 ×(2), 13–19.
• Dadali, V. A. (2024). Основы биохимии для нутрициологов. [Fundamentals of biochemistry for nutritionists]. GEOTAR.

• Dadali, V. A., & Dadali, Yu. V. (2011). Микронутриенты в профилактике метаболического синдрома. - Вопросы здорового и диетического питания. [Micronutrients in the prevention of metabolic syndrome. Issues of Healthy and Dietary Nutrition], × 10 ×, 3–11.
• Litvinenko L.M., Fershikov A.G., Panchenko B.V., Dadali V.A., Savelova V.A. THEORETICAL ANALYSIS OF THE STRUCTURE AND INTRAMOLECULAR DYNAMICS OF IMIDAZOLIUM HALIDE AND N-METHYLIMIDAZOLIUM HALIDE ION PAIRS. Theoretical and Experimental Chemistry. 1986. Т. 21. № 5. С. 497-504.