Draft:Matthis Synofzik
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Matthis Synofzik | |
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| Born | Germany |
| Nationality | German |
| Alma mater | University of Tübingen & Munich School of Philosophy |
| Scientific career | |
| Fields | Precision Medicine, Neurology, Neurogenetics, Neuroscience, Philosophy & Ethics |
| Institutions | University of Tübingen, Germany |
| Website | hih-tuebingen.de |
Matthis Synofzik is a German translational neurologist and research neuroscientist. He is Professor (apl. Prof.) for Translational Genomics of Neurodegenerative Disease and leads the research division of Translational Genomics of Neurodegenerative Diseases at the Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Germany.
Education
[edit]Synofzik studied Philosophy at the Munich School of Philosophy and at the University of Tübingen. Concurrently, he studied Medicine. He earned his clinical medical qualification (2006), as well as was awarded his Philosophy degree (Magister artium) from the University of Tübingen. In 2008, he submitted his thesis[1] in the field of cognitive neuroscience and was awarded his doctorate (Dr. med.) at the University of Tübingen. In 2013, he completed his board certification in clinical neurology at the University of Tübingen. In 2014, he was appointed as a consultant neurologist with a main focus on neurodegenerative diseases, and established his research laboratory, focusing on genetic, molecular and cognitive neuroscience levels of systems neurodegeneration. In 2015, he completed his (Habilitation) (Qualification for full professorship) in Neurology at the University of Tübingen titled Clinics and Genetics of autosomal-recessive ataxias.[2]
Research interests
[edit]His work focuses on understanding the mechanisms of neurodegenerative diseases, particularly in the areas of hereditary ataxias, motor neuron diseases (ALS; hereditary spastic paraplegias), frontotemporal dementia and Alzheimer’s Disease. In his next-generation precision medicine and translational neuroscience approach, he combines next-generation genomics, biomarker development of ultra-sensitive fluid protein biomarkers, digital-motor biomarkers, and disease progression modeling to develop and investigate individualized molecular precision therapies. In his clinical practice, he specializes in diagnosing and treating patients with hereditary neurodegenerative disorders like hereditary ataxias, motor neuron diseases, frontotemporal dementia and Alzheimer’s Disease. He focuses on developing and applying advanced therapies, including RNA therapies and personalized medicine approaches. His clinical interests also extend to other rare and complex neurological disorders, where he combines diagnostic precision with cutting-edge research to develop individualized treatment plans for his patients.[citation needed]
Synofzik is known for his contributions to genetic research on ataxias and spastic paraplegias. He leads large-scale genomic initiatives like the PREPARE GENESIS database, which holds over 3,000 next-gen sequencing datasets for ataxia.[citation needed]
Synofzik has contributed to the creation of multimodal progression models for diseases like frontotemporal dementia and ataxias, incorporating data from fluid biomarkers, clinical outcomes, and neuroimaging. These models are essential for understanding disease dynamics and preparing for clinical trials.[citation needed]
Career
[edit]Following the completion of his Habilitation, Synofzik added clinical subspecialization in Geriatrics (2016) and Palliative Medicine (2018). In 2018, he was appointed professor (apl. Prof.) at the University of Tuebingen. In 2020, he assumed leadership of the research division of Translational Genomics of Neurodegenerative Diseases at the Hertie Institute for Clinical Brain Research. [citation needed]
Awards
[edit]Synofzik has received several awards and honors throughout his career, including:
- FARA - Bronya J. Keats International Research Collaboration Award on Friedreich Ataxia - 2017
- Else-Kröner Fresenius Stiftung - Clinical Scientist Scholarship - 2016-2018
- German Hereditary Ataxia Society (DHAG) - Heredo-Ataxia Prize - 2012
- University of Tübingen - Attempto-Award for the Neurosciences[3] - 2009
External links
[edit]References
[edit]- ^ Synofzik, Matthis (2008). "Die Rolle interner Modelle bei der Wahrnehmung von Eigenbewegungen". Thesis (in German).
- ^ Synofzik, Matthis Benjamin (2015). "Klinik und Genetik autosomal-rezessiver Ataxien". Habilitation (in German).
- ^ Synofzik, Matthis; Lindner, Axel; Thier, Peter (2008-06-03). "The cerebellum updates predictions about the visual consequences of one's behavior". Current Biology. 18 (11): 814–818. Bibcode:2008CBio...18..814S. doi:10.1016/j.cub.2008.04.071. ISSN 0960-9822. PMID 18514520.