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Draft:Antonella Santuccione Chadha

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  • Comment: Please remove all external links from the draft text. References may include external links to the source, but words in the running text may not. bonadea contributions talk 09:41, 31 December 2024 (UTC)
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Dr. Antonella Santuccione Chadha (*1974) is a medical doctor and neuroscientist specialized in clinical pathology, and expert in neurological and psychiatric disorders as well as sex and gender precision medicine. She is the founder and pro bono CEO of the Women’s Brain Foundation (formerly Women’s Brain Project Association), an international non-profit organization dedicated to investigating sex- and gender-specific differences in the brain and their impact on the prevalence and progression of psychiatric as well as neurological disorders.[1] [2] Additionally, she is the Vice President and Board Member of Euresearch, a Swiss organization that supports research and innovation projects across Europe. [3] Dr. Santuccione Chadha also advises several start-ups focused on advancing the diagnosis and treatment of psychiatric and neurological disorders, contributing to the progress of precision medicine and making effective treatments more accessible. [1]

Personal Life

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Antonella Santuccione Chadha grew up in a small village in the Abruzzo region of Italy. She spent her childhood on her grandparents’ farm, as her parents —a teacher and a police officer— were often away due to their professions. She now resides in Thalwil, near Lake Zurich, with her husband and two sons. She is particularly committed to researching sex and gender differences in medicine, which led her to establish the Women’s Brain Foundation. [2]

Professional Career

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Dr. Antonella Santuccione Chadha completed her medical studies with distinction in 1999 at the Gabriele d'Annunzio University Chieti (https://en.unich.it/) in Italy. After completing her doctoral thesis at the University Hospital in Chieti and the Institute of Medical Statistics, she interned at the European Commission (Brussels, Belgium). [1] She subsequently worked as a resident doctor in clinical pathology at the University Hospital Chieti.

In 2001, she began her postdoctoral research at the Center for Molecular Neurobiology at the University Hospital Hamburg-Eppendorf in Germany. Her career also included postdoctoral fellowships at the Institute of the University Hospital Siena in Italy and the Institute for Clinical Pathology at the University Hospital Zurich in Switzerland.[4] [5]

From 2006 to 2012, Dr. Santuccione Chadha led the neurobiology research group at the psychogeriatric unit of the University Hospital Zurich, focusing on dementia, schizophrenia, depression, psychosis, and substance abuse. During this time, she was supervised by Professor Dr. Christoph Hock and Professor Dr. Nitsch, pioneers in neuroimmunology and discoverers of Aducanumab.[6] In this role, she led a team of doctoral students, technicians, and nurses. During this period, she also completed various training courses and clinical studies in Good Clinical Practice (Zurich, Switzerland), advanced training in Cognitive Behavioral Psychotherapy (Munich, Germany), and advanced training in clinical research study management (Zurich, Switzerland). [7]

In 2012, Antonella Santuccione Chadha joined Roche in Grenzach-Wyhlen (Germany) as a Medical Manager for Psychiatry. Alongside her work at Roche, she served as a consultant at the Lausanne Dialogue Workshops, a global initiative for Alzheimer's disease.[8] From 2014 to June 2018, she worked as a clinical expert for psychiatric and neurological disorders at Swissmedic (Bern, Switzerland).[7] During this time, she founded the Women’s Brain Foundation and served on the ROADMAP expert advisory board. [9]

Dr. Santuccione Chadha returned to Roche in 2018 as a Director in the medical department for Alzheimer’s disease (partnership and biomarkers). [7] During the COVID-19 pandemic, she offered pro bono support to the regional government in Abruzzo, Italy, for crisis management. [2] From 2020 to 2022, she led the Alzheimer's disease division (Stakeholder Engagement for Alzheimer’s) at Biogen (Baar, Switzerland). Since 2021, she has served as Vice President and a member at Euresearch (www.euresearch.ch). [1] In 2022, she became Chief Medical Officer at Altoida (www.altoida.com), a U.S.-based neurocognitive assessment platform, and in 2023, she was appointed CEO.[1] As of 2024, she advises BottneuroAG (www.bottneuro.ch) and ReconnectLab AG (www.reconnect-labs.com). [10] [11]

Antonella Santuccione Chadha is the author of numerous scientific publications. Her current research interest focuses on the influence of sex and gender factors on psychiatric disorders and their consideration in diagnostic and treatment solutions, a goal she pursues through her foundation, the Women’s Brain Foundation. [7]

Women’s Brain Foundation (formerly “Women’s Brain Project”)

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The Women’s Brain Foundation (WBF) is an international non-profit organization headquartered in Basel, Switzerland, that unites a global team of scientists from various disciplines. Founded in 2016, the foundation seeks to establish the first research institute for sex- and gender-specific precision medicine in Switzerland. The idea arose during Chadha's work at Swissmedic, where she observed that eight out of ten medications withdrawn from the market were due to fatal side effects in women.[1]

The foundation focuses on applying sex and gender in precision medicine, spanning from basic research to new technologies. It supports and promotes research on sex- and gender differences with the goal of advancing precision medicine and accelerating innovations in women's health. While its primary focus is on brain disorders, the foundation’s initiatives extend to other areas of women’s health. The WBF gained international recognition for its research on sex-specific differences in Alzheimer’s disease, a condition that disproportionately affects women. [1]

Goals of the Women’s Brain Foundation [1]

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  1. Promoting sex and gender-specific research: The WBF advocates for a stronger consideration of sex and gender in biomedical research to develop personalized treatment approaches.
  2. Education: The organization aims to raise awareness of the importance of sex and gender-specific differences in brain health.
  3. Advancing precision medicine: By integrating sex and gender-specific data, the foundation seeks to enable tailored prevention, diagnosis, and treatment.
  4. Collaboration: Promoting interdisciplinary exchange between scientists, clinicians, and policymakers.

Key Topics

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Awards

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For her work, Antonella Santuccione Chadha, who has been listed among the Top 100 Women in Business in Switzerland since 2018, has received several awards:

  • 2018-2023: TOP 100 Business Women in Switzerland
  • 2019: “Woman of the Year” in Switzerland, awarded by the magazine Women in Business[12]
  • 2020: World Sustainability Award for her contributions to advancing precision medicine[13]
  • 2021: Women for Innovation Switzerland [1]
  • 2021: Premio Medicina Italia [1]
  • 2022: Bold Women Award Switzerland[14]
  • 2023: Trailblazer [1]
  • 2024: Empowering Women Award[15]
  • 2024: Katherinenturm[16]

Publications

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Scientific publications (a selection, presented in chronological order)

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  • Santuccione A, Sytnyk V, Leshchyns’ka I and Schachner M. Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. Journal of Cell Biology 2005; 169(2): 341-54. (highlighted in Science)
  • Sutter R, Shakhova O, Penkar S, Bhagat H, Sutter C, Santuccione A, Bernays R, Heppner F, Brandner S, Schuller U, Grotzer M, Moch H, Schraml P and Marino S. Cerebellar stem cells act as medulloblastoma initiating cells in a mouse model and a neural stem cell signature characterises a subset of human medulloblastoma. Oncogene 2010; 29: 1845-56.
  • Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, Schachner M. Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth. J Neurosci. 2010; 30(27):9292-305.
  • Zhang X, Santuccione A, Leung C and Marino S. Fate specification of glial progenitors but not proliferation of granule cell progenitors is controlled by Bmi1 through BMP pathway inhibition during cerebellar development. Glia 2011; 59:1118-31.
  • Santuccione Chadha A, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, BernreutherC, Welt T, GrimmJ, Glatzel M, Rajendran L, Hock C and Nitsch RM.Active vaccination with ankyrin G reduces -amyloid pathology in APP transgenic mice. Molecular Psychiatry 2012; 18(3):358- 68 7.
  • Tackenberg C, Grinschgl S, Trutzel A, Santuccione Chadha A, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis 2013; 25;4:e608.
  • Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM. Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. Mol Psychiatry 2013; 18(3):358-68.
  • Gruber O, Santuccione Chadha A, Aach H. Magnetic resonance imaging in studying schizophrenia, negative symptoms, and the glutamate system. Front Psychiatry 2014; 3(5):32.
  • Welt T, Kulic L, Hoey SE, McAfoose J, Späni C, Santuccione Chadha A, Fisher A, Nitsch RM. Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study. J Alzheimers Dis. 2015;46(4):971-82.
  • Ferretti M T, Schumacher Dimech A, Baracchi F M. Iulita F, Cavedo E, Chiesa PA, Chadha Santuccione A, Girouard H, Misoch S, Giacobini E, Depypere H, Hampel H. Sex and gender-specific phenotypes of Alzheimer’s disease: gateway to precision medicine. Nat Rev Neurol 2018 (8):457-469.
  • Jacoline CB,P Jonsson, C Reed,D O’Rourke, A Santuccione Chadha,N Hedberg,A Makady, E Xoxi, C Gispen-de-Wied, A Schiel, R Long, Gallacher Regulatory and health technology assessment considerations for disease-modifying drugs in Alzheimer’s disease. CNS Drugs 2018, 32(12):1085-1090.
  • Ferretti MT, Santuccione-Chadha A, Hampel H. Nature. Account for sex in brain research for precision medicine. 2019; 569(7754):40.
  • Biskup E, Quevenco FC, Ferretti MT, Santuccione-Chadha A. Sex differences in brain metabolic activity: Beyond the concept of brain age. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10630-10631.
  • Ferretti MT, Martinkova J, Biskup E, Benke T, Gialdini G, Nedelska Z, Rauen, Mantua, Religa D, Hort J, Santuccione Chadha A, Schmidt R Sex and gender differences in Alzheimer's disease: current challenges and implications for clinical practice. European Journal of Neurology, 2020, 27(6):928-943.
  • Cirillo D, Catuara Solar S, Morey C, Guney E, Subirats L, Mellino S, Gigante A, Valencia A, Rementeria MR, Santuccione Chadha A, Mavridis N. Sex and gender differences and biases in Artificial Intelligence for Biomedicine and Healthcare. npj Digit. Med. 2020 3, 81.
  • Ferrari A, Santus E, Cirillo D, Ponce-de-Leon M, Marino N, Ferretti MT, Santuccione Chadha A, Mavridis N, Valencia A. Simulating SARS-CoV-2 epidemics by region-specific variables and modeling contact tracing app containment. NPJ Digit Med. 2021 Jan 14;4(1):9.
  • Santus E, Marino N, Cirillo D, Chersoni E, Montagud A, Santuccione Chadha A, Valencia A, Hughes K, Lindvall C. Artificial Intelligence-Aided Precision Medicine for COVID-19: Strategic Areas of Research and Development. J Med Internet Res. 2021 Mar 12;23(3):e22453.
  • Schumacher Dimech A, Ferretti MT, Sandset EC, Santuccione Chadha A. The role of sex and gender differences in precision medicine. The work of the Women’s Brain Project. Eur Heart J. 2021;42(34):3215-3217.
  • Butlen-Ducuing F, Balkowiec-Iskra E, Dalla C, Slattery DA, Ferretti MA, Kokras N, Balabanov P, C De Vries, Mellino S, Santuccione Chadha A. Implications of sex-related differences in central nervous system disorders for drug research and development. Nat Rev Drug Discov. 2021 Dec;20(12):881-882.
  • Martinkova J, Quevenco F C, Karcher H, Ferrari Alberto, Sandset E, Szoeke C, Hort J, Schmidt R, Santuccione Chadha A, Ferretti MT. Gender ratio and reporting of gender-stratified results in clinical trials for Alzheimer’s disease: systematic review and meta-analysis. JAMA Open. 2021;4(9):e2124124.
  • Ferretti MT, Santuccione Chadha A. The missing X factor in Alzheimer disease. Nat Rev Neurol. 2021 Dec;17(12):727-728.
  • Robbert L. Harms, A Ferrari, B. Meier, Martinkova, E Santus, N Marino, D Cirillo, S Mellino, S Catuara Solar, Ioannis Tarnanas, C Szoeke, A Valencia, Maria Teresa Ferretti, Azizi Seixas, A Santuccione Chadha. Sex and Gender differences in a digital biomarkers for Alzheimers’ Disease. EPMA J . 2022;13(2):299-313.
  • Gustavsson A, Norton N, Fast T, Frölich L, Georges J, Holzapfel D, Kirabali T, Krolak-Salmon P, Rossini PM, Ferretti MT, Lanman L, Chadha AS, van der Flier WM. Global estimates on the number of persons across the Alzheimer's disease continuum. Alzheimers Dement. 2023;19(2):658-670.
  • Hentzen NB, Ferretti MT, Santuccione Chadha A, et al. Mapping of European activities on the integration of sex and gender factors in neurology and neuroscience. Eur J Neurol. 2022; 29: 2572-2579.
  • Jensen A, Stromme M, Moyassari S, Santuccione Chadha A, Carmela Tartaglia C, Szoeke C, Ferretti MT, COVID-19 vaccines: Considering sex differences in efficacy and safety. Contemp Clin Trials 2022;115:106700.
  • Dawson WD, Smith E, Booi L, Mosse M, Lavretsky H, Reynolds CF 3rd, Cummings J, Brannally P, Hynes W, Lenze EJ, Manes F, Ayadi R, Frank L, Chapman SB, Robertson IH, Rubenstein L, Jraissati J, Ibáñez A, Fillit H, Jeste DV, Rao A, Berk M, Storch EA, Santuccione Chadha A, Eyre HA. Investing in Late-Life Brain Capital. Innov Aging. 2022 May 18;6(3):igac016.
  • Muurling M, de Boer C, Vairavan S, Harms RL, Chadha AS, Tarnanas I, Luis EV, Religa D, Gjestsen MT, Galluzzi S, Ibarria Sala M, Koychev I, Hausner L, Gkioka M, Aarsland D, Visser PJ, Brem AK. Augmented reality versus standard tests to assess cognition and function in early Alzheimer's disease. NPJ Digit Med. 2023 Dec 18;6(1):234.
  • Marino N, Putignano G, Cappilli S, Chersoni E, Santuccione A, Calabrese G, Bischof E, Vanhaelen Q, Zhavoronkov A, Scarano B, Mazzotta AD, Santus E. Towards AI-driven longevity research: An overview. Front Aging. 2023 1;4:1057204.
  • Owolabi MO, Leonardi M, Bassetti C, Jaarsma J, Hawrot T, Makanjuola AI, Dhamija RK, Feng W, Straub V, Camaradou J, Dodick DW, Sunna R, Menon B, Wright C, Lynch C, Chadha AS, Ferretti MT, Dé A, Catsman-Berrevoets CE, Gichu M, Tassorelli C, Oliver D, Paulus W, Mohammed RK, Charway-Felli A, Rostasy K, Feigin V, Craven A, Cunningham E, Galvin O, Perry AH, Fink EL, Baneke P, Helme A, Laurson-Doube J, Medina MT, Roa JD, Hogl B, O'Bryan A, Trenkwalder C, Wilmshurst J, Akinyemi RO, Yaria JO, Good DC, Hoemberg V, Boon P, Wiebe S, Cross JH, Haas M, Jabalpurwala I, Mojasevic M, DiLuca M, Barbarino P, Clarke S, Zuberi SM, Olowoyo P, Owolabi A, Oyesiku N, Maly-Sundgren PC, Norrving B, Soekadar SR, van Doorn PA, Lewis R, Solomon T, Servadei F. Global synergistic actions to improve brain health for human development. Nat Rev Neurol. 2023;19(6):371-383.
  • Baez S., Castro-Aldrete L., Britton GB, Ibanez A, Santuccione A. Enhancing brain health in the global south through a sex and gender lens. Nat. Mental Health 2024; 2: 1308–1317.
  • Ferretti MT, Ding H, Au R, Liu C, Devine S, Auerbach S, Mez J, Gurnani A, Liu Y, Santuccione A, Ang TFA. Maximizing utility of neuropsychological measures in sex-specific predictive models of incident Alzheimer's disease in the Framingham Heart Study. Alzheimers Dement. 2024;20(2):1112-1122.
  • Winter SF, Walsh D, Catsman-Berrevoets C, Feigin V, Destrebecq F, Dickson SL, Leonardi M, Hoemberg V, Tassorelli C, Ferretti MT, Dé A, Chadha AS, Lynch C, Bakhtadze S, Saylor D, Hwang S, Rostasy K, Kluger BM, Wright C, Zee PC, Dodick DW, Jaarsma J, Owolabi MO, Zaletel J, Albreht T, Dhamija RK, Helme A, Laurson-Doube J, Amos A, Baingana FK, Baker GA, Sofia F, Galvin O, Hawrot T. National plans and awareness campaigns as priorities for achieving global brain health. Lancet Glob Health. 2024;12(4):e697-e706.
  • Vargas-Gonzalez JC, Chadha AS, Castro-Aldrete L, Ferretti MT, Tartaglia MC. Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer's disease. Nat Aging. 2024;4(11):1538-1543.

Books and Book Chapters

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  • Edited together with Maria Teresa Ferretti und Anne Marie Schumacher Dimech: Sex and Gender Differences in Alzheimer’s Disease. Academic Press, 2021. ISBN 978-0-12-819344-0[17]
  • With Maria Teresa Ferretti and Viviana Kasam: Una bambina senza testa. Mondo Nuovo, 2021. ISBN 978-88-32115-54-3[18]
  • With Maria Teresa Ferretti and Simona Mellin: The Women’s Brain Project, Buchkapitel in Sex and Gender Bias in Technology and Artificial Intelligence. Elsevier, 2022. ISBN: 9780128213926
  • With Simona Mellino, Enrico Santus, Dario Motti: Innovating Health Against Future Pandemics. Elsevier, 2024. ISBN: 9780443136818

Key Contributions to Public Reports

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  • Official scientific report by the expert panel for Bovine Spongiform Encephalopathy (BSE), European Commission: Geographical risk assessment of bovine spongiform encephalopathy (GBR) in Pakistan (2001); Geographical risk assessment (GBR) of bovine spongiform encephalopathy in India (2001)
  • Draft guidelines for the clinical investigation of medicinal products for the treatment of Alzheimer’s disease and other dementias (2016) https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-clinical-investigation-medicines-treatment-alzheimers-disease-and-other-dementias_en.pdf
  • Women and Dementia in Europe – Addressing the disproportionately high burden of dementia on women (2017), European Institute of Women’s Health, Women-and-dementia-in-Europe-report-2017.pdf
  • Understanding the Social and Economic Impact of Neurological Disorders Worldwide. The Economist the_value_of_action-_mitigating_the_global_impact_of_neurological_disorders_infographic1_sep_2022.pdf
  • Gender-Specific Research on Neurological Disorders. The Economist Impact, WomensBrainProject_report_230306.pdf
  • Societal Impact of Research Funding for Women’s Health, WHAM and RAND Report, TheWHAMReport_ADRD.pdf
  • Brain health-directed policymaking a new concept to strengthen democracy, Brookings Institution, 2022. https://www.brookings.edu/wp-content/uploads/2022/11/Brain-health-directed-policymaking_Final.pdf

Patent

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Santuccione A, Merlini M, Hoch C., Nitsch R. Ankyrin G (ankG) or an agent derived thereof for use in the treatment, amelioration or prevention of a neurological disorder, 2012. https://patentimages.storage.googleapis.com/a2/19/79/a25e2721276c2b/WO2012113775A1.pdf

Grants and Funding

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  • 2009-2011 Novartis Research Foundation. Project „Funktionelle Bedeutung eines neuen Antigens in der Pathophysiologie der Alzheimer-Krankheit“; PI: Prof. Christoph Hock, Co-investigator: Dr. Antonella Santuccione.
  • 2008-2010 Swiss Commission for Research Partnerships with Developing Countries (KFPE). Project: “Functional significance of a new antigen in the pathophysiology of Alzheimer’s disease”; PI: Dr. Antonella Santuccione, Co-Investigator: Dr. Aparna Shetty.
  • 2017 and 2019 SNF grants for the 2nd Forum on “Women’s Brain and Mental Health”.
  • Multiple research grants for the Women’s Brain Foundation.

Public talks

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Media

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BBC, Financial Times, La Stampa, La Repubblica, Le Temps, Swissinfo, The Independent, CFI, NZZ, Sky24, SRF Tagesschau, Sonntag Zeitung, Rai, The Guardian, Geo Wissen, il Corriere della sera, Businesswire, The Economist, TV France, RAI, France 24.

Start Up Advisor

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Authority Data (Person): GND: 1238193633 (lobid, OGND) | VIAF: 47166233716496040062

References

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  1. ^ a b c d e f g h i j k Women's Brain Foundation https://www.womensbrainproject.com/. Retrieved 29 December 2024. {{cite web}}: Missing or empty |title= (help)
  2. ^ a b c Stallmach, Lena (14 January 2021). "Frauen werden in der Medizin oft behandelt, als wären sie Männer. Das will Antonella Santuccione Chadha ändern". www.nzz.ch. NZZ. Retrieved 29 December 2024.
  3. ^ Euresearch. "Euresearch Association - Presidium and Board". EURESEARCH. Retrieved 2024-12-29.
  4. ^ Schweizerischer Nationalfonds. "Antonella Santuccione". Schweizerischer Nationalfonds. Retrieved 29 December 2024.
  5. ^ Lüscher, Martin (19 August 2022). "Kaffee mit..." FuW. Retrieved 29 December 2024.
  6. ^ Sina, Christina (17 June 2021). "New treatment option for Alzheimer patients". Institute for Regenerative Medicine. Universität Zürich. Retrieved 30 December 2024.
  7. ^ a b c d Elsevier. "Antonella Chadha Santuccione". Elsevier - Series Editor. Retrieved 30 December 2024.
  8. ^ Alzheimer Europe (12 December 2024). "Lausanne XI Workshop focuses on opportunities for action and collaboration". Alzheimer Europe. Retrieved 30 December 2024.
  9. ^ ROADMAP. "Advisory Group". ROADMAP. Retrieved 30 December 2024.
  10. ^ Bottneuro. "Dr. Antonella Santuccione Chadha joined as an Advisor". Bottneuro - News & Events. Retrieved 30 December 2024.
  11. ^ reconnect labs. "OUR TEAM". reconnect labs. Retrieved 30 December 2024.
  12. ^ Women in Business (27 February 2020). "WOMAN OF THE YEAR 2019 – Antonella Santuccione Chadha". Women in Business. Retrieved 30 December 2024. {{cite web}}: |last1= has generic name (help)
  13. ^ MDPI. "Announcing the Recipients of the 2020 World Sustainability Award and Emerging Sustainability Leader Award". MDPI. Retrieved 30 December 2024.
  14. ^ FACES Magazin (19 September 2022). "Bold & Bubbly: Veuve Clicquot Bold Woman Award". FACES. Retrieved 30 December 2024.
  15. ^ Welti, Dörte. "Dr Antonella Santuccione Chadha: Elephants have more money than women to solve problems". Ladies Drive. Retrieved 30 December 2024.
  16. ^ Bahls, Christine. "Founder and CEO of the Women's Brain Foundation to be Honoured for Role in Shaping Swiss History". Women's Brain Foundation. Retrieved 30 December 2024.
  17. ^ Santuccione Chadha, Antonella (23 July 2021). Sex and Gender Differences in Alzheimer's Disease (1sr ed.). Elsevier. ISBN 9780128193440.
  18. ^ Santuccione Chadha, Antonella (11 March 2021). una bambina senza testa. Edizioni Mondo Nuovo. ISBN 978-88-32115-54-3.
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