CGB5

CGB5
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1HCN, 1HRP, 1QFW,%%s1QFW, 1HCN, 1HRP
Identifiers
Aliases	CGB5, HCG, CGB, hCGB, chorionic gonadotropin beta subunit 5, chorionic gonadotropin subunit beta 5
External IDs	OMIM: 608825; HomoloGene: 37338; GeneCards: CGB5; OMA:CGB5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,045,311 bp
RNA expression pattern
	Top expressed in
	placenta; ; gonad; ; Pituitary Gland; ; anterior pituitary; ; duodenum; ; embryo; ; muscle tissue; ; left testis; ; body of pancreas; ; smooth muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space; cytoplasm;
Biological process	peptide hormone processing; apoptotic process; signal transduction; female gamete generation; cell-cell signaling; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; hormone-mediated signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	93659
	n/a
	ENSG00000189052
	n/a
	P0DN86
	n/a
	NM_033043
	n/a
NP_000728.1; NP_149032.1; NP_149133.1; NP_149439.1; NP_149032;
	NP_149439
	n/a
	Wikidata
View/Edit Human

Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ^[3]

Function

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chorionic gonadotropin, beta polypeptide 5". Retrieved 2014-08-28.

Lustbader, J. W.; Birken, S; Pileggi, N. F.; Kolks, M. A.; Pollak, S; Cuff, M. E.; Yang, W; Hendrickson, W. A.; Canfield, R. E. (1989). "Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states". Biochemistry. 28 (24): 9239–43. doi:10.1021/bi00450a001. PMID 2611225.
Ghosh, D; Ezashi, T; Ostrowski, M. C.; Roberts, R. M. (2003). "A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene". Molecular Endocrinology. 17 (1): 11–26. doi:10.1210/me.2002-0223. PMID 12511603.
Couvelard, A; Paraf, F; Vidaud, D; Dubois, S; Vidaud, M; Fléjou, J. F.; Degott, C (2004). "Human chorionic gonadotrophin beta expression in malignant Barrett's oesophagus". Virchows Archiv. 445 (3): 279–84. doi:10.1007/s00428-004-1078-1. PMID 15309632. S2CID 24519855.
Kuorelahti, A; Rulli, S; Huhtaniemi, I; Poutanen, M (2007). "Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation". Endocrinology. 148 (8): 3694–703. doi:10.1210/en.2007-0249. hdl:11336/27509. PMID 17510243.
Dominguez-Lopez, P; Diaz-Cueto, L; Ulloa-Aguirre, A; Lopez-Valle, M. A.; Arechavaleta-Velasco, F (2008). "No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women". Endocrine. 34 (1–3): 117–20. doi:10.1007/s12020-008-9103-9. PMID 19002615. S2CID 30505243.
Chen, Y; Miyazaki, J; Nishizawa, H; Kurahashi, H; Leach, R; Wang, K (2013). "MTA3 regulates CGB5 and Snail genes in trophoblast". Biochemical and Biophysical Research Communications. 433 (4): 379–84. doi:10.1016/j.bbrc.2013.02.102. PMC 3761375. PMID 23510993.
Hanna, C. W.; Bretherick, K. L.; Liu, C. C.; Stephenson, M. D.; Robinson, W. P. (2010). "Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage". Human Reproduction. 25 (10): 2664–71. doi:10.1093/humrep/deq211. PMID 20716560.
Eskild, A; Fedorcsak, P; Mørkrid, L; Tanbo, T. G. (2012). "Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy". Fertility and Sterility. 98 (4): 905–10. doi:10.1016/j.fertnstert.2012.06.011. PMID 22769733.
Tegoni, M; Spinelli, S; Verhoeyen, M; Davis, P; Cambillau, C (1999). "Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunits". Journal of Molecular Biology. 289 (5): 1375–85. doi:10.1006/jmbi.1999.2845. PMID 10373373.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189052 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Chorionic gonadotropin, beta polypeptide 5". Retrieved 2014-08-28.

[1]

[2]

[3]

Function

References

Further reading