Bruceolide
Appearance
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IUPAC name
Methyl 3,11β,12α,15β-tetrahydroxy-2,16-dioxo-13,20-epoxy-13β-picras-3-en-21-oate
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Systematic IUPAC name
Methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,4,9-tetrahydroxy-8,11a-dimethyl-5,10-dioxo-1,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-2H-3,3a1-(epoxymethano)phenanthro[10,1-bc]pyran-3-carboxylate | |
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3D model (JSmol)
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CompTox Dashboard (EPA)
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Properties | |
C21H26O10 | |
Molar mass | 438.429 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bruceolide is a quassinoid that has been isolated from Bischofia javanica. Synthetic derivatives have shown in vitro antimalarial activity.[1][2]
References
[edit]- ^ Murakami, Nobutoshi; Umezome, Takashi; Mahmud, Taifo; Sugimoto, Masanori; Kobayashi, Motomasa; Wataya, Yusuke; Kim, Hye-Sook (March 1998). "Anti-malarial activities of acylated bruceolide derivatives". Bioorganic & Medicinal Chemistry Letters. 8 (5): 459–462. doi:10.1016/S0960-894X(98)00045-6. PMID 9871598.
- ^ Organization, World Health (1999). WHO monographs on selected medicinal plants. Geneva: World Health Organization. p. 63. ISBN 9241545178.