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Bengt Mannervik

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Bengt Mannervik
Born
Bengt Eriksson

(1943-08-19) 19 August 1943 (age 81)
Stockholm, Sweden
EducationNorra Real, Stockholm, Stockholm University (Ph.D. 1969)
Known forStudies of enzymes involved in glutathione metabolism
AwardsBjörkén Prize (Uppsala University)
Scientific career
FieldsBiochemistry
InstitutionsStockholm University, Uppsala University, Scripps Research Institute, La Jolla, California, and many visiting appointments

Bengt Mannervik (born 19 August 1943 in Stockholm),[1] is a Swedish biochemist known especially for work on enzymes related to glutathione metabolism.

Education

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After secondary education under his birth name, Bengt Eriksson, at Norra Real in Stockholm, Bengt Mannervik studied at Stockholm University[1] where he obtained his Licenciate of Philosophy in chemistry with a thesis on biochemistry in 1967. He obtained a Ph.D. there in 1969, and became a Docent (associate professor) at Stockholm University in 1970.

Career

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Bengt Mannervik was Senior Lecturer in the Department of Biochemistry at Stockholm University from 1970 to 1987, and was Acting Chairman for numerous periods between 1971 and 1988.[2] In 1988 he moved to Uppsala University as holder of the Karin and Herbert Jacobsson endowed chair in biochemistry.[1] He was Chairman of the Biochemistry Department from 1998 to 2010. From 2010 to 2012 he was a Senior Professor at Uppsala University, and was a member of the university senate from 2005 to 2008.[2]

In 2010 he became Professor at Stockholm University.[3] In addition he was an adjunct professor at the Scripps Research Institute in La Jolla, California, between 2013 and 2019.

Visiting professorships

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He has had visiting professorships at UC Berkeley; University of Chieti, Italy; University of Perugia, Italy; the Scripps Research Institute, La Jolla, California; and the Collège de France, Paris[2]

Professional services

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He has fulfilled roles in numerous professional organizations, including the Swedish Biochemical Society (secretary 1976–1982); Chairman of the Swedish National Committee on Biochemistry, Royal Swedish Academy of Sciences, 1988–1990; Chairman Scientific Program Committee for the 22nd Meeting of the Federation of European Biochemical Societies, FEBS 1993; editorial boards of the Biochemical Journal, ChemBioChem, Biochimica et Biophysica Acta, Protein Engineering Design and Selection, the Journal of Biological Chemistry.

In addition, he has had advisory roles at various companies: Telik Inc.; PanVera Corporation, Pharmacia Biotech; Uniroyal Chemical Company; Biovitrum AB; Maxygen; Vividion; Oxford Biomedical Research, Rochester Hills, Michigan.

Research

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From the beginning of his career[4] Bengt Mannervik studied enzymes of glutathione metabolism, including studies of levels in different tissues,[5] structure and catalytic activity of glutathione transferase,[6] a purification method,[7] a detailed review on the isoenzymes of glutathione transferase,[8] and many others. These publications have had a major influence on the field of glutathione biochemistry. Each of those mentioned above, together with three others, had been cited more than 1000 times by the end of 2024, the first[5] more than 5000 times, leading to an h index of 89, as calculated by Google Scholar.[9] In all he has had nearly 600 publications, with a combined total of more than 47000 citations.

His interest in glutathione transferases continued until the last years of his research, for example studies of their role as efficient ketosteroid isomerases[10] and as enzymes involved in the biosynthesis of moulting hormones in mosquitoes transmitting malaria and yellow fever.[11]

In addition to the work directed specifically at enzymes involved in glutathione metabolism and detoxication,[12] Mannervik coauthored texts on molecular toxicology.[13][14]

He also studied various more general aspects of enzymology, including graphical analysis,[15] error structure of kinetic experiments,[16] weighting of observations,[17][18] regression methods,[19] directed enzyme evolution,[20] and discrimination between models.[21]

Major contributions were more recently directed to the evolution of novel functions by in vitro protein evolution.[22][23][24]

Honours

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Bengt Mannervik (born Eriksson) studied at the prestigious high school Norra Real in Stockholm and was given the prize for the best graduate in 1962. In 1988 he won the competition among 20 applicants for the internationally advertised Karin and Herbert Jacobsson Professorship of Biochemistry at Uppsala University, originally held by Nobel Prize Laureate Arne Tiselius.[1] In 2013 he was awarded the Björkén Prize of Uppsala University.[25] He was elected to the Academia Europaea in 2023.[2] He was elected to the American Association of Cancer Research, and the Royal Society of Sciences at Uppsala. He is an Honorary Member of the American Society of Biochemistry and Molecular Biology

References

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  1. ^ a b c d "Curriculum vitae" (PDF). Stockholm University. Retrieved 24 December 2024.
  2. ^ a b c d "Bengt Mannervik". Academia Europaea. Retrieved 27 December 2024.
  3. ^ Stockholm University, https://www.su.se/english/profiles/bmann-1.188234
  4. ^ Eriksson, Bengt (1966). "On the synthesis and enzymatic reduction of the coenzyme A- glutathione mixed disulfide". Acta Chem. Scand. 20 (4): 1178–1179. doi:10.3891/acta.chem.scand.20-1178. PMID 5965128.
  5. ^ a b Moron, Maria S.; Depierre, Joseph W.; Mannervik, Bengt (1979). "Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver". Biochim. Biophys. Acta. 582 (1): 67–78. doi:10.1016/0304-4165(79)90289-7. PMID 760819.
  6. ^ Mannervik, Bengt; Danielson, U. Helena; Ketterer, Brian (1988). "Glutathione Transferases—Structure and Catalytic Activity". Crit. Rev. Biochem. 23 (3): 283–337. doi:10.3109/10409238809088226. PMID 3069329.
  7. ^ Carlberg, Inger; Mannervik, Bengt (1985). Glutathione reductase. Methods Enzymol. Vol. 113. pp. 484–490. doi:10.1016/S0076-6879(85)13062-4. ISBN 978-0-12-182013-8. PMID 3003504.
  8. ^ Mannervik, Bengt (1985). "The isoenzymes of glutathione transferase". Advances in Enzymology and Related Areas of Molecular Biology. Vol. 57. pp. 357–417. doi:10.1002/9780470123034.ch5. ISBN 978-0-471-89011-9. PMID 3898742. {{cite book}}: |journal= ignored (help)
  9. ^ Google Scholar: accessed 25 December 2024: https://scholar.google.com/citations?user=RymaWmIAAAAJ&hl=en&oi=ao
  10. ^ Mannervik, Bengt; Ismail, Aram; Lindstrom, Helena; Sjödin, Birgitta; Ing, Nancy H. (2021). "Glutathione transferases as efficient ketosteroid isomerases". Front. Mol. Biosci. 8: 765970. doi:10.3389/fmolb.2021.765970. PMC 8645602. PMID 34881290.
  11. ^ Šťastná, Katarína; Musdal, Yaman; Ismail, Aram; Ebihara, Kana; Niwa, Ryusuke; Mannervik, Bengt (2024). "Supreme glutathione-dependent ketosteroid isomerase in the yellow-fever transmitting mosquito Aedes aegypti". Biochem. Biophys. Res. Comm. 711: 149914. doi:10.1016/j.bbrc.2024.149914. PMID 38608434.
  12. ^ Mannervik, B., ed. (2024). Versatility of Glutathione Transferase Proteins. Basel: MDPI. ISBN 978-3-7258-0454-2.
  13. ^ Josephy, P. D.; Mannervik, B. (2006). Molecular Toxicology. Oxford University Press.
  14. ^ Mannervik, B.; Morgenstern, R. (2024). Glutathione transferases. Comprehensive Toxicology (4th ed.).
  15. ^ Mannervik, Bengt (1975). "Graphical analysis of steady-state kinetic data of multireactant enzymes". Anal. Biochem. 63 (1): 12–16. doi:10.1016/0003-2697(75)90184-0. PMID 1167422.
  16. ^ Mannervik, B.; Jakobson, I.; Warholm, M. (1986). "Error structure as a function of substrate and inhibitor concentration in enzyme kinetic experiments". Biochem. J. 235 (3): 797–804. doi:10.1042/bj2350797. PMC 1146758. PMID 3753447.
  17. ^ Mannervik, B.; Jakobson, I.; Warholm, M. (1979). "A new procedure to derive weighting factors for nonlinear regression analysis applied to enzyme kinetic data". Biochim. Biophys. Acta. 567 (1): 43–48. doi:10.1016/0005-2744(79)90170-0. PMID 454628.
  18. ^ Mannervik, B. Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models. Contemporary Enzyme Kinetics and Mechanism (ed. D. Purich). pp. 73–94.
  19. ^ Mannervik, B. (1975). "Nonlinear regression methods in design of experiments and mathematical modelling. Applications to the analysis of the steady-state kinetics of glutathione reductase". BioSystems. 7 (1): 101–119. Bibcode:1975BiSys...7..101M. doi:10.1016/0303-2647(75)90048-9. PMID 239774.
  20. ^ Larsson, Anna-Karin; Emrén, Lars O.; Bardsley, William G.; Mannervik, Bengt (2004). "Directed enzyme evolution guided by multidimensional analysis of substrate-activity space". Protein Eng. Des. Sel. l17 (1): 49–55. doi:10.1093/protein/gzh005. PMID 14985537.
  21. ^ Mannervik, Bengt; Bártfai, T. "Discrimination between mathematical models of biological systems exemplified by enzyme steady state kinetics". Acta Biol. Med. Germanica. 31 (2): 203–221.
  22. ^ Norrgård, M. A.; Ivarsson, Y.; Tars, K.; Mannervik, B. (2006). "Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution". Proc. Natl. Acad. Sci. USA. 103 (13): 4876–4881. Bibcode:2006PNAS..103.4876N. doi:10.1073/pnas.0600849103. PMC 1458763. PMID 16549767.
  23. ^ Kurtovic, S.; Mannervik, B. (2009). "Identification of emerging quasi-species in directed enzyme evolution". Biochemistry. 48 (40): 9330–9339. doi:10.1021/bi901168q. PMID 19746988.
  24. ^ Ismail, A.; Govindarajan, S.; Mannervik, B. (2024). "Human GST P1-1 redesigned for enhanced catalytic activity with the anticancer prodrug Telcyta and improved thermostability". Cancers. 16 (4): 762. doi:10.3390/cancers16040762. PMC 10887215. PMID 38398153.
  25. ^ "The Björkén Prize". 6 September 2024.
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