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Protein-coding gene in the species Homo sapiens
BRD2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X0J , 2DVQ , 2DVR , 2DVS , 2DVV , 2E3K , 2G4A , 2YDW , 2YEK , 3AQA , 3ONI , 4A9E , 4A9F , 4A9H , 4A9I , 4A9J , 4A9M , 4A9N , 4A9O , 4AKN , 4ALG , 4ALH , 4J1P , 4MR5 , 4MR6 , 4QEU , 4QEV , 4QEW , 4UYF , 4UYG , 4UYH , 5BT5 , 5DFD , 5HEM , 5DFB , 5HEL , 5HFQ , 5HEN , 5DFC , 5IG6 , 5IBN , 5DW1
Identifiers Aliases BRD2 External IDs OMIM : 601540 ; MGI : 99495 ; HomoloGene : 74540 ; GeneCards : BRD2 ; OMA :BRD2 - orthologs Wikidata
Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene . BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3 , BRD4 , and BRDT in mammals [ 5] [ 6] [ 7]
Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila signal transduction pathway involved in growth control.[ 7]
BRD2 has been implicated in cancer.[ 5] [ 8]
BRD2 loss in mice causes obesity without diabetes for unknown reasons.[ 5]
BRD2 may have functional overlap with close homolog BRD3.[ 9]
BRD2 function is blocked by BET inhibitors . BRD2 has been shown to interact with E2F2 ,[ 10] [ 11] GATA1 .[ 9]
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