TSPYL5 (gene)

TSPYL5
Identifiers
Aliases	TSPYL5, TSPY like 5
External IDs	OMIM: 614721; MGI: 2442458; HomoloGene: 14134; GeneCards: TSPYL5; OMA:TSPYL5 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	97,277,928 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	33,688,030 bp
RNA expression pattern
	Top expressed in
	testicle; ; seminal vesicula; ; spinal ganglia; ; corpus epididymis; ; tail of epididymis; ; superior vestibular nucleus; ; lateral nuclear group of thalamus; ; lactiferous duct; ; trigeminal ganglion; ; cardiac muscle tissue of right atrium;
	Top expressed in
	spermatocyte; ; Amygdala; ; visual cortex; ; hippocampus proper; ; prefrontal cortex; ; piriform cortex; ; dorsal striatum; ; nucleus of stria terminalis; ; primary visual cortex; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus;
Biological process	regulation of growth; nucleosome assembly; positive regulation of protein kinase B signaling; positive regulation of protein ubiquitination; cellular response to gamma radiation; positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	85453
	239364
	ENSG00000180543
	ENSMUSG00000038984
	Q86VY4
	Q69ZB3
	NM_033512
	NM_001085421
	NP_277047
	NP_001078890
	Wikidata
View/Edit Human	View/Edit Mouse

TSPY like 5 is a protein that in humans is encoded by the TSPYL5 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180543 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038984 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TSPY like 5". Retrieved 2018-09-06.

Jung Y, Park J, Bang YJ, Kim TY (February 2008). "Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers". Lab. Invest. 88 (2): 153–60. doi:10.1038/labinvest.3700706. PMID 18059362.
Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG (February 2010). "TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway". Biochem. Biophys. Res. Commun. 392 (3): 448–53. doi:10.1016/j.bbrc.2010.01.045. PMID 20079711.
Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R (January 2011). "TSPYL5 suppresses p53 levels and function by physical interaction with USP7". Nat. Cell Biol. 13 (1): 102–8. doi:10.1038/ncb2142. PMID 21170034. S2CID 288643.
Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM (April 2013). "TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression". Mol. Endocrinol. 27 (4): 657–70. doi:10.1210/me.2012-1397. PMC 3607698. PMID 23518928.
Qiu X, Hu B, Huang Y, Deng Y, Wang X, Zheng F (January 2016). "Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance". Dig. Dis. Sci. 61 (1): 149–57. doi:10.1007/s10620-015-3878-3. PMID 26386860. S2CID 22547345.
Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V (May 2016). "Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression". Hum. Mol. Genet. 25 (9): 1714–27. doi:10.1093/hmg/ddw043. PMC 4986328. PMID 26911678.
Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, Ponnusamy MP, Batra SK, Ganti AK (July 2017). "MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53". Clin. Cancer Res. 23 (14): 3906–3917. doi:10.1158/1078-0432.CCR-16-2530. PMC 5511558. PMID 28196872.
Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ (February 2017). "Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma". BMC Cancer. 17 (1): 158. doi:10.1186/s12885-017-3134-7. PMC 5326500. PMID 28235398.
Shao L, Shen Z, Qian H, Zhou S, Chen Y (December 2017). "Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5". DNA Cell Biol. 36 (12): 1108–1116. doi:10.1089/dna.2017.3904. PMID 28972400.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180543 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038984 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TSPY like 5". Retrieved 2018-09-06.

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References

Further reading