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Phil S. Baran

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Phil S. Baran
BornAugust 10, 1977 (1977-08-10) (age 47)
Denville, NJ
NationalityAmerican
Alma materLake Sumter Community College (AA, 1995)
New York University (BS, 1997)
Scripps Research Institute (PhD, 2001)
Scientific career
FieldsChemistry
InstitutionsSkaggs Institute for Chemical Biology

Phil S. Baran (born August 10, 1977) is a synthetic organic chemist and Professor in the Department of Chemistry at the Scripps Research Institute.[1] His work is focused on synthesizing complex natural products,[2] the development of new reaction methodologies within synthetic organic electrochemistry,[3] and the development of new reagents.[4] He holds several patents and has authored nearly 300 research articles.

Early life and education

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Phil S. Baran was born in Denville, New Jersey, on August 10, 1977, and grew up in Coral Springs, Florida. He remembers being a poor student at high school, preferring to play role-playing games, write computer programs and build with Lego.[5]

Encouraged by his chemistry teacher to experiment after school, Baran quickly channeled his creativity into crafting molecules. In 1995 he began a chemistry degree at New York University, and enthusiastically accepted [David] Schuster’s offer to work in his lab, synthesizing compounds that linked C60 with porphyrins to make artificial photosynthetic systems.[5] He received his BS in chemistry from New York University in 1997.

He went on to earn his PhD from The Scripps Research Institute in 2001, under the supervision of K. C. Nicolaou, an experience he recalls was 'like hardcore Navy Seal training'[5] and where he co-authored 30 papers in less than four years.

He then pursued a postdoctoral fellowship in the laboratory of Nobel Laureate Elias James Corey at Harvard University who reflected on Baran's time in his lab, saying, "He had a phenomenal grasp of synthetic chemistry," and "felt that he could be a leader in his generation."[5]

Independent academic career

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Neon OPEN sign above Phil Baran's office door

Phil Baran began his independent career at the Scripps Research Institute in the summer of 2003, at only 26 years old, and received tenure just three years later. In the 20 years since then, he has supervised over 300 graduate students, post-doctoral scholars, visiting scholars and interns.[6] He is currently the Dr. Richard A. Lerner Endowed Chair at Scripps Research[7]

His work is focused on practicality and simplicity in the total synthesis of organic molecules, eschewing protecting groups, functional group manipulations, and non-essential redox manipulations. Several of his total syntheses are now being adopted for commercial production. His contributions in methodology center around practical C-H functionalization reactions and have had a remarkable impact based on actual drug candidates brought into the clinic using these methods and the sales of numerous reagents he has commercialized for use in the pharmaceutical industry.[8] Additionally, since the mid 2010's, Baran's lab has focused on developing electrochemical methodologies for use in total synthesis and medicinal chemistry as it allows for more atom economical and environmentally-conscious protocols.

Phil Baran has given hundreds of talks all over the world and is the recipient of dozens of distinguished awards. Among many honors, he has notably earned the Amgen Young Investigator Award (2005), ACS Award in Pure Chemistry (2010), the MacArthur Fellowship (2013), the Mukaiyama Award (2014), the ACS Elias J. Corey Award (2016), the Danisco Science Excellence Medal Award (2022), and the Edison Patent Award (2023).[9]

Industry career and collaborations

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In addition to his numerous achievements in academia, Baran also holds many accolades in industry as a scientific entrepreneur, company co-founder, consultant and scientific advisor. He co-founded his first company Sirenas Marine Discovery in 2012 alongside Eduardo Esquenazi and Jake Beverage —a company that is dedicated to marine-inspired molecular discoveries and pre-clinical leads for cancer, HIV, and infectious diseases.[10] In 2016, he joined forces with fellow Scripps colleagues, Benjamin F. Cravatt and Jin-Quan Yu to co-found Vividion Therapeutics with the goal of identifying small molecules that bind currently undrugged targets via a covalent-first chemoproteomics approach.[11] Vividion was sold to Bayer in 2021 for $2 billion ($1.5 billion with an additional $500 million in milestone payments).[12] In the same year, Baran founded Elsie Biotechnologies, an antisense oligonucleotide (ASO)-based company with the goal of discovering therapeutic agents that can achieve desirable medicinal effects not attainable with existing drugs by modulating gene expression of DNA or RNA.[13] Elsie Biotechnologies was sold to GlaxoSmithKline (GSK) in 2024 for $50 million. Baran also co-founded and is on the scientific advisory team of Galileo Biosystems, a preclinical stage biopharmaceutical company focused on developing therapeutic agents for inflammatory and autoimmune diseases.[14] He also serves on the scientific advisory board for seven additional companies (Eisai, Kemxtree, Quanta Therapeutics, Inc., Alkermes, Inc, Nutcracker Therapeutics, Inc., Hongene Biotech Corporation, and Sage Therapeutics) and has consulted for over twenty more, including presently at Bristol-Meyers-Squibb, Gilead, and BASF Corporation.[3][9]

IKA ElectraSyn 2.0

In 2014, Baran began a partnership with IKA, well-known laboratory equipment manufacturer, to bring to market a revolutionary piece of equipment that promised to standardize electrochemical protocols and make electrochemistry accessible to the average organic chemist. [15] Three years after the partnership began, the ElectraSyn was debuted in a Steve Jobs-esque fashion at the American Chemical Society annual meeting, drawing a large crowd of eager chemists.[16] In the seven years since, the ElectraSyn and subsequent ElectraSyn 2.0 have been widely adopted into the synthetic community and utilized towards hundreds of research articles and patents.[17] The publicity surrounding Baran's (as well as Jin-Quan Yu's) partnership with IKA was highlighted with a memorable promotional video found here.

Total syntheses

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  • Dragocins A−C (2024)[18]
  • Dynobactin A (2024)
  • (−)-Cyclopamine (2023)
  • (+)-KB343 (2023)
  • Portimine A and B (2023)
  • Kibdelomycin (2022)
  • Darobactin A (2022)
  • (+)-Calcipotriol (2022)
  • Tagetitoxin (2020)
  • (–)-Maximiscin (2020)
  • Taxol (2020)
  • Teleocidins B-1-B-4 (2019)
  • Herqulines B and C (2019)
  • (–)-Thapsigargin (2017)
  • Ariaosamines (2016)
  • (–)-Maoecrystal V (2016)
  • Pallambins C and D (2016)
  • (+)-Phorbol (2016)
  • Verruculogen (2015)
  • Fumitremorgin A (2015)
  • Ouabagenin (2013, 2015)
  • Dixiamycin B (2014)
  • (+)-Ingenol (2014)
  • (–)-Taxuyunnanine (2014)
  • (+)-Hongoquercin A (2013)
  • Phellodonin (2013)
  • Sarcodonin (2013)
  • Pipercyclobutanamide A (2012)
  • (+)-Taxadienone (2011)
  • (+)-Psychotetramine (2011)
  • (–)-Palau’amine (2010)
  • Vinigrol (2009)
  • (±)-Massadine (2008)
  • (±)-Psychotrimine (2008)
  • Cortistatin A (2008)
  • (–)-Axinellamine A and B (2008)
  • (±)-Chartelline C (2006)
  • Haouamine A (2006)
  • Avrainvillamide (2005)
  • Stephacidin A & B (2005)
  • (S)-Ketorolac (2005)
  • Sceptrin (2004)

Publications

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Phil S. Baran has authored and co-authored nearly 300 research publications and has an h-index of 126 with over 50,000 citations across his group's publications.[19] Articles authored by Baran and his group can be found in numerous prestigious journals including Science, Nature, Journal of American Chemical Society (JACS), Angewandte Chemie, Journal of Organic Chemistry (JOC), among several others.

Baran co-wrote the digital interactive reference text The Portable Chemist’s Consultant: A Survival Guide for Discovery, Process, and Radiolabeling as well as several book chapters and forewords.[20][21][22][23][24][25][26][27]

Community engagement

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  1. Skaggs Graduate School Commencement Ceremony (2024)
  2. Reddit AMA, 2016
  3. "What Makes a Good Chemist"

Awards and honors

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  • Highly Cited Researcher, yearly, 2014–2024[28]
  • Edison Patent Award, 2023
  • Horizon Discovery Prize, Royal Society of Chemistry, 2022
  • Danisco Science Excellence Medal Award, 2022
  • Bristol Chemical Synthesis Syngenta Award, 2021
  • Janssen Prize for Creativity, 2020
  • Inhoffen Medal, 2019
  • Manchot Research Professorship, 2017
  • Member, The National Academy of Sciences, 2017
  • Emanuel Merck Lectureship, 2017[29]
  • Mukaiyama Award, 2014
  • MacArthur Fellowship, 2013
  • Royal Society of Chemistry Synthetic Organic Chemistry Award, 2013
  • ACS San Diego Section Distinguished Scientist Award, 2012
  • ISHC Katritzky Heterocyclic Chemistry Award, 2011
  • Thieme–IUPAC Prize in Synthetic Organic Chemistry, 2010
  • ACS Award in Pure Chemistry, 2010
  • Sackler Prize, 2009
  • Novartis Lecturer, 2007–2008
  • Hirata Gold Medal, 2007
  • National Fresenius Award, 2007
  • Pfizer Award for Creativity in Organic Chemistry, 2006
  • Beckman Young Investigators Award, 2006[30]
  • Alfred P. Sloan Foundation Fellow, 2006–2008
  • BMS Unrestricted "Freedom to Discover" Grant, 2006–2010
  • NSF Career, 2006–2010
  • Eli-Lilly Young Investigator Award, 2005–2006
  • AstraZeneca Excellence in Chemistry Award, 2005
  • DuPont Young Professor Award, 2005
  • Roche Excellence in Chemistry Award, 2005
  • Amgen Young Investigator Award, 2005
  • Searle Scholar Award, 2005
  • GlaxoSmithKline Chemistry Scholar Award, 2005–2006
  • Nobel Laureate Signature Award for Graduate Education in Chemistry, ACS, 2003
  • National Institutes of Health Post-Doctoral Fellowship Award, Harvard, 2001–2003
  • Hoffmann-La Roche Award for Excellence in Organic Chemistry, 2000
  • Lesly Starr Shelton Award for Excellence in Chemistry Graduate Studies, 2000
  • National Science Foundation Pre-Doctoral Fellowship Award, Scripps, 1998–2001

References

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  1. ^ The Baran Laboratory Archived June 6, 2017, at the Wayback Machine, Scripps Research Institute
  2. ^ "Baran Lab". Retrieved August 27, 2023.
  3. ^ a b "Phil S. Baran" (PDF). Retrieved August 27, 2023.
  4. ^ "Baran Group – Professor Product Portal". Sigma-Aldrich.
  5. ^ a b c d Peplow, Mark (2014). "The sultan of synthesis". Features. Chemistry World. Vol. 11. Royal Society of Chemistry. ISSN 1473-7604. OCLC 5585253041. Retrieved November 12, 2024.
  6. ^ "Former Group Members | Baran Lab". Retrieved November 20, 2024.
  7. ^ "Philip Baran | Scripps Research". www.scripps.edu. Retrieved November 20, 2024.
  8. ^ "Phil S. Baran | American Academy of Arts and Sciences". www.amacad.org. October 8, 2024. Retrieved November 20, 2024.
  9. ^ a b "About Phil S Baran | Baran Lab". Retrieved November 20, 2024.
  10. ^ "About". Sirenas. Retrieved November 20, 2024.
  11. ^ "About Us". Vividion Therapeutics. Retrieved November 20, 2024.
  12. ^ "Bayer acquires small molecule startup Vividion Therapeutics for up to $2 billion". Chemical & Engineering News. Retrieved November 20, 2024.
  13. ^ "News". Elsie Biotechnologies. Retrieved November 20, 2024.
  14. ^ "About". Galileo Biosystems. Retrieved November 20, 2024.
  15. ^ PhD, Kevin Davies (August 22, 2017). "Electrifying Catalysis: IKA Takes Bite Out of Apple to Launch Electrochemistry Product". GEN - Genetic Engineering and Biotechnology News. Retrieved November 20, 2024.
  16. ^ Hickman, Daniel (August 24, 2017). "Dawn of a New Age in Synthetic Organic Electrochemistry". ChemistryViews. Retrieved November 20, 2024.
  17. ^ "Publications | Baran Lab". Retrieved November 20, 2024.
  18. ^ Smith, Brendyn P.; Truax, Nathanyal J.; Pollatos, Alexandros S.; Meanwell, Michael; Bedekar, Pranali; Garrido-Castro, Alberto F.; Baran, Phil S. (May 6, 2024). "Total Synthesis of Dragocins A−C through Electrochemical Cyclization". Angewandte Chemie International Edition. 63 (19): e202401107. doi:10.1002/anie.202401107. ISSN 1433-7851. PMC 11619770. PMID 38358802.
  19. ^ "Phil Baran". scholar.google.com. Retrieved November 12, 2024.
  20. ^ Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Sodium 1,1-Difluoroethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01783, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  21. ^ Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Zinc Difluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01787, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  22. ^ Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Isopropylsulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01785, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  23. ^ Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Trifluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01786, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  24. ^ Pan, Chung-Mao; Ishihara, Yoshihiro; Baran, Phil S. (March 31, 2016), "Palau'chlor", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01901, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  25. ^ Li, Jie Jack; Limberakis, Chris; Pflum, Derek A. (January 10, 2008). Modern Organic Synthesis in the Laboratory. Oxford University Press. doi:10.1093/oso/9780195187984.001.0001. ISBN 978-0-19-518798-4.
  26. ^ Li, Jie Jack (September 28, 2006), "Cardiovascular Drugs: From Nitroglycerin to Lipitor", Laughing Gas, Viagra, and Lipitor, Oxford University Press, doi:10.1093/oso/9780195300994.003.0008, ISBN 978-0-19-530099-4, retrieved November 12, 2024
  27. ^ Li, Jie Jack, ed. (March 30, 2009). Name Reactions for Homologations, Part I. Hoboken, NJ, USA: John Wiley & Sons, Inc. doi:10.1002/9780470487020. ISBN 978-0-470-48702-0.
  28. ^ "Scripps Research scientists make annual Highly Cited Researchers list". www.scripps.edu. Retrieved November 21, 2024.
  29. ^ Merck Group
  30. ^ "Phil S. Baran". Arnold and Mabel Beckman Foundation. Archived from the original on August 2, 2018. Retrieved August 1, 2018.
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