HS6ST2

HS6ST2
Identifiers
Aliases	HS6ST2, heparan sulfate 6-O-sulfotransferase 2, MRXSPM
External IDs	OMIM: 300545; MGI: 1354959; HomoloGene: 9277; GeneCards: HS6ST2; OMA:HS6ST2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	132,961,395 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	50,770,733 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; renal medulla; ; testicle; ; middle temporal gyrus; ; placenta; ; ventricular zone; ; entorhinal cortex; ; Brodmann area 46;
	Top expressed in
	Epithelium of choroid plexus; ; lateral septal nucleus; ; Gonadal ridge; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; calvaria; ; nucleus accumbens; ; habenula; ; dorsal striatum; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; heparan sulfate 6-O-sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; membrane; nucleoplasm;
Biological process	heparan sulfate proteoglycan biosynthetic process, enzymatic modification; glycosaminoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	90161
	50786
	ENSG00000171004
	ENSMUSG00000062184
	Q96MM7
	Q80UW0
	NM_001077188; NM_147175; NM_001394073; NM_001394074; NM_147174
	NM_001077202; NM_001290467; NM_001290468; NM_015819
	NP_001070656; NP_671704
	NP_001070670; NP_001277396; NP_001277397; NP_056634
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene. ^[5]

Function

Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration.

This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171004 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Heparan sulfate 6-O-sulfotransferase 2". Retrieved 2016-07-11.

Habuchi H, Miyake G, Nogami K, Kuroiwa A, Matsuda Y, Kusche-Gullberg M, Habuchi O, Tanaka M, Kimata K (2003). "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties". Biochem. J. 371 (Pt 1): 131–42. doi:10.1042/BJ20021259. PMC 1223259. PMID 12492399.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171004 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062184 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Heparan sulfate 6-O-sulfotransferase 2". Retrieved 2016-07-11.

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Function

References

Further reading