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Non-coding RNA in the species Homo sapiens
In molecular biology, GNAS antisense RNA (non-protein coding) , also known as GNAS-AS1 , is a long non-coding RNA .It is antisense to the GNAS gene . It is an imprinted gene , expressed only from the paternal allele , suggesting that it may have a role in suppression of the paternal NESP55 allele encoded by GNAS.[ 3]
Tobi EW, Lumey LH, Talens RP, et al. (2009). "DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific" . Hum. Mol. Genet . 18 (21): 4046– 4053. doi :10.1093/hmg/ddp353 . PMC 2758137 . PMID 19656776 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55– 65. doi :10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Hayward BE, Bonthron DT (2000). "An imprinted antisense transcript at the human GNAS1 locus" . Hum. Mol. Genet . 9 (5): 835– 841. doi :10.1093/hmg/9.5.835 . PMID 10749992 .
Wroe SF, Kelsey G, Skinner JA, et al. (2000). "An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3342– 3346. doi :10.1073/pnas.050015397 . PMC 16241 . PMID 10716699 .
Li T, Vu TH, Zeng ZL, et al. (2000). "Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus" . Genomics . 69 (3): 295– 304. doi :10.1006/geno.2000.6337 . PMID 11056047 .
Williamson CM, Skinner JA, Kelsey G, Peters J (2002). "Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster". Mamm. Genome . 13 (2): 74– 79. doi :10.1007/s00335-001-2102-2 . PMID 11889554 . S2CID 22736144 .