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English: Low magnification micrograph of a tubulovillous adenoma, TVA. Surgical specimen. H&E stain.

TVAs are precancerous lesions that have a mixture a villous morphology and tubular morphology, where the villous component is <50% of the lesion, but greater or equal to 25% of the lesion.

TVAs have nuclear changes like those in tubular adenomas and villous adenomas:

  • Nuclear elongation; elliptical nuclei,
  • Nuclear crowding/pseudostratification.

Morphologic changes include:

  • Loss of goblet cells,
  • Hyperchromatic ("open") nuclei at the luminal surface.

Tubular morphology:

  • Round gland-like structures.

Villous morphology:

  • Long finger-like projections; similar in appearance to villi.
Source Own work
Author Nephron

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current16:04, 10 October 2009Thumbnail for version as of 16:04, 10 October 20093,444 × 2,204 (1.09 MB)Nephron{{Information |Description={{en|1=Low magnification micrograph of a '''tubulovillous adenoma''', TVA. Surgical specimen. H&E stain. TVAs are precancerous lesions that have a mixture a villous m

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