TVAs are precancerous lesions that have a mixture a villous morphology and tubular morphology, where the villous component is <50% of the lesion, but greater or equal to 25% of the lesion.
TVAs have nuclear changes like those in tubular adenomas and villous adenomas:
Nuclear elongation; elliptical nuclei,
Nuclear crowding/pseudostratification.
Morphologic changes include:
Loss of goblet cells,
Hyperchromatic ("open") nuclei at the luminal surface.
Tubular morphology:
Round gland-like structures.
Villous morphology:
Long finger-like projections; similar in appearance to villi.
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{{Information |Description={{en|1=Low magnification micrograph of a '''tubulovillous adenoma''', TVA. Surgical specimen. H&E stain. TVAs are precancerous lesions that have a mixture a villous m