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File:SREBP regulatory mechanism.png

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Summary

Description
English: When sterol levels are high in the endoreticulum (ER), SREBP, SCAP and INSIG form a stable complex. When sterol levels drop, SCAP dissociate from INSIG and escorts SREBP into the Golgi apparatus, where two proteases, S1P and S2P, act sequentially to release the N-terminal bHLH domain of SREBP. The SREBP bHLH domain enters the nucleus to activate the transcription of genes with SREBP-responsive elements (SRE). Genes regulated by SREBP usually function to increase cellular sterol content, including the genes involved in sterol synthesis and the uptake of low-density lipoprotein (LDL).
Date
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Author Artemister

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Captions

SREBP regulates transcription in response to sterol levels

Items portrayed in this file

depicts

SREBP

INSIG

SREBF chaperone

inception

2 June 2019

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Date/TimeThumbnailDimensionsUserComment
current19:11, 2 June 2019Thumbnail for version as of 19:11, 2 June 2019904 × 1,305 (187 KB)ArtemisterUser created page with UploadWizard

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