File:MiRNA processing.JPG

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Summary

Description

English: Overview of microRNA processing in animals, from transcription to the formation of the effector complex.

Enzymes:
Pol II (transcription) and associated proteins
Drosha, Pasha (pri-miRNA → pre-miRNA)
RAN-GTP, Exportin-5 (export from nucleus)
Dicer (pre-miRNA → miRNA)
RISC (effector complex)

Abbrevations:
pri-miRNA = primary microRNA transcript
pre-miRNA = precursor microRNA
miRNA = microRNA
miRNA* = antisense microRNA
miRISC = microRNA-induced silencing complex

Date

9 January 2008

Source

Self-made, based on an illustration in Esquela-Kerscher A, Slack FJ (2006). "Oncomirs — microRNAs with a role in cancer". Nature Reviews Cancer 6 (4): 259–69. DOI:10.1038/nrc1840. PMID 16557279.

Author

w:User:Narayanese

Other versions

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Licensing

I, the copyright holder of this work, release this work into the public domain. This applies worldwide.
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File history

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	Date/Time	Dimensions	User	Comment
current	20:38, 24 July 2008	838 × 1,496 (211 KB)	Narayanese	oops, was supposed to be 3' overhang, fixed now
	20:28, 24 July 2008	838 × 1,496 (211 KB)	Narayanese	Changed to short 3' overhang in pre-miRNA, per Yoontae Lee et al Nature 2003.
	22:05, 18 June 2008	838 × 1,496 (211 KB)	Narayanese	Green protein oval, more enzymes, same source as before
	01:30, 13 January 2008	838 × 1,496 (165 KB)	Narayanese	added drosha, pasha, dicer
	16:56, 9 January 2008	838 × 1,496 (143 KB)	Narayanese	{{Information \|Description= \|Source=self-made \|Date= \|Location= \|Author= \|Permission= \|other_versions= }}
	13:09, 9 January 2008	838 × 1,804 (156 KB)	Narayanese	{{Information \|Description= \|Source=self-made \|Date= \|Location= \|Author= \|Permission= \|other_versions= }}
	12:29, 9 January 2008	847 × 1,810 (147 KB)	Narayanese	{{Information \|Description=Overview of microRNA processing \|Source=self-made \|Date=9 January 2008 \|Location= \|Author= \|Permission= \|other_versions= }}