File:Luong LD SA F2.jpg

Figure is adapted from Luong, P. Basic Principles of Genetics, Connexions Web site (2009) under a Creative Commons Attribution License (CC-BY 3.0). Further modification of the figure is performed by the image uploader with reference from Davis PK, Brackmann RK. Chromatin remodeling and cancer. Cancer Biol Ther. 2:22 (2003). PMID 12673113.

Caption: Chromatin remodeling complexes in the dynamic regulation of transcription: In the presence of acetylated histones (HAT mediated) and absence of methylase (HMT) activity, chromatin is loosely packaged. Additional nucleosome repositioning by chromatin remodeler complex, SWI/SNF opens up DNA region where transcription machineray proteins, like RNA Pol II, transcription factors and co-activators bind to turn on gene transcription. In the absence of SWI/SNF, nucleosomes can not move farther and remain tightly aligned to one another. Additional methylation by HMT and deacetylation by HDAC proteins condenses DNA around histones and thus, make DNA unavailable for binding by RNA Pol II and other activators, leading to gene silencing.

This work is licensed under the Creative Commons Attribution 3.0 License. https://creativecommons.org/licenses/by/3.0/CC-BY-3.0Creative Commons Attribution 3.0truetrue

This file is a candidate to be copied to Wikimedia Commons. Any user may perform this transfer; refer to Wikipedia:Moving files to Commons for details. If this file has problems with attribution, copyright, or is otherwise ineligible for Commons, then remove this tag and DO NOT transfer it; repeat violators may be blocked from editing. Other Instructions Endorse this file for transfer by adding |human=<your username> to this Template. If this file is freely licensed, but otherwise unsuitable for Commons (e.g. out of Commons' scope, still copyrighted in the US), then replace this Template with {{Do not move to Commons|reason=<Why it can't be moved>}} If you think that a local copy of this file should be retained, then replace this Template with {{Keep local|reason=<Why a local copy is needed>}} Please ensure that the file has a properly descriptive and unambiguous name before transferring; see Wikipedia:File mover#What files should be renamed? for details.

This file was suggested for transfer by a bot (User:Svenbot). Please verify that this file is suitable for Commons before transferring it.