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File:Fibrinogen to fibrin coagulation.svg

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Summary

Description
English: Blood soluble fibrinogens turn to insoluble fibrins to facilitate blood clotting.

1. FpAs are cut off by thrombin. New N-terminals link to γA chains of D domains and protofibrils begin to form.

2. FpBs are cut off by thrombin a bit later. New N-terminals link to Bβ chains of D domains. αCs previously bound by FpBs are also released. αCs allow for bi- and equilateral branching.

3. XIIIa cross-links fibrins (dark blue lines). C-terminal γA-γA- and Aα-Aα-cross-links form.

  • Cyan: Aα chains
  • Red: Bβ chains
  • Pink: γA chains
  • FpA: fibrinopeptides A
  • FpB: fibrinopeptides B
  • αC: Aα chain C-terminal domain
  • D: D domain
  • E: E domain
  • IIa: thrombin
  • XIIIa: factor XIIIa (activated form)
  • Bi: bilateral branching
  • Eq: equilateral branching

Source for info (picture adapted from figure 3.1):

Date
Source Own work
Author 5-HT2AR

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14 November 2019

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Date/TimeThumbnailDimensionsUserComment
current05:56, 15 November 2019Thumbnail for version as of 05:56, 15 November 2019820 × 620 (20 KB)5-HT2ARadded B-b interaction between the B knob sequences (red lines)
17:56, 14 November 2019Thumbnail for version as of 17:56, 14 November 2019820 × 620 (21 KB)5-HT2ARUser created page with UploadWizard

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