File:Clopidogrel activation.svg
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Summary
| Description |
English: Clopidogrel (top left) being activated. The active metabolite (top right) has Z configuration at the double bond C3–C16 and possibly R configuration at the newly asymmetric C4.
The first step is a cytochrome P450 mediated oxidation; the two structures at the bottom are tautomers of each other; and the final step is a hydrolysis. |
| Date | |
| Source | Own work, based on Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, Pascal M, Herbert JM, Maffrand JP, Picard C (2002). "Structure and stereochemistry of the active metabolite of clopidogrel". Drug Metab. Dispos. 30 (11): 1288–95. DOI:10.1124/dmd.30.11.1288. PMID 12386137. |
| Author | Anypodetos |
This W3C-invalid structural formula was created with BKchem-Inkscape.
Licensing
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This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. |
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:47, 24 December 2011 | | 533 × 323 (110 KB) | Anypodetos | Fix stereochemistry |
| 12:30, 24 December 2011 |  | 533 × 323 (107 KB) | Anypodetos | Fix bond width | |
| 12:22, 24 December 2011 |  | 533 × 323 (107 KB) | Anypodetos | {{Information |Description ={{en|1={{w|clopidogrel}} (top left) being activated. The active metabolite (top right) has ''Z'' configuration at the double bond C3–C16 and and ''S'' configuration at the newly asymmetric C7. ({{cite journal | author = Pe |
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