DGKQ

DGKQ
Identifiers
Aliases	DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs	OMIM: 601207; MGI: 102918; HomoloGene: 20352; GeneCards: DGKQ; OMA:DGKQ - orthologs
EC number	2.7.1.107
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 958,887 bp End 986,895 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 53.24 cM Start 108,794,559 bp End 108,817,538 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum pancreatic ductal cell granulocyte jejunal mucosa mucosa of transverse colon right hemisphere of cerebellum middle temporal gyrus duodenum mucosa of sigmoid colon thymus Top expressed in primary visual cortex superior frontal gyrus cerebellar cortex dentate gyrus of hippocampal formation granule cell right kidney lip genital tubercle neural layer of retina jejunum granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding phospholipase binding metal ion binding kinase activity kinase binding protein binding ATP binding diacylglycerol kinase activity transmembrane receptor protein tyrosine kinase activator activity NAD+ kinase activity Cellular component cytoplasm cytosol nuclear speck membrane plasma membrane cytoskeleton nucleus endosome vesicle membrane nuclear matrix presynapse postsynapse glutamatergic synapse Biological process G protein-coupled receptor signaling pathway thrombin-activated receptor signaling pathway response to ATP intracellular signal transduction phosphorylation regulation of transcription by RNA polymerase II protein kinase C signaling platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway signal transduction glycerolipid metabolic process diacylglycerol metabolic process lipid phosphorylation regulation of gluconeogenesis phosphatidic acid biosynthetic process activation of transmembrane receptor protein tyrosine kinase activity regulation of G protein-coupled receptor signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation cAMP-mediated signaling positive regulation of peptidyl-tyrosine phosphorylation response to cAMP regulation of cholesterol metabolic process regulation of TORC1 signaling regulation of cortisol biosynthetic process regulation of progesterone biosynthetic process metabolism regulation of synaptic vesicle endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1609 110524 Ensembl ENSG00000145214 ENSMUSG00000004815 UniProt P52824 Q6P5E8 RefSeq (mRNA) NM_001347 NM_199011 NM_001357029 RefSeq (protein) NP_001338 NP_950176 NP_001343958 Location (UCSC) Chr 4: 0.96 – 0.99 Mb Chr 5: 108.79 – 108.82 Mb PubMed search
Wikidata
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Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.

Interactions

DGKQ has been shown to interact with RHOA.

Further reading

• Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
• Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
• van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
• Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
• Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.