CLIC6
Appearance
(Redirected from CLIC6 (gene))
CLIC6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CLIC6, CLIC1L, chloride intracellular channel 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]
The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]
Interactions
[edit]CLIC6 has been shown to interact with Dopamine receptor D3.[7]
Function
[edit]CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
- ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6".
- ^ Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- ^ Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.
Further reading
[edit]- Singh H (May 2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–2121. Bibcode:2010FEBSL.584.2112S. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
- Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome. 13 (8): 456–462. doi:10.1007/s00335-001-2157-0. hdl:11586/196820. PMID 12226712. S2CID 26059147.
- Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
- Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.
External links
[edit]- CLIC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.