BZW1

BZW1
Identifiers
Aliases	BZW1, BZAP45, Nbla10236, basic leucine zipper and W2 domains 1, 5MP2
External IDs	MGI: 1914132; HomoloGene: 41651; GeneCards: BZW1; OMA:BZW1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,827,338 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,446,512 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; amniotic fluid; ; germinal epithelium; ; Epithelium of choroid plexus; ; gingival epithelium; ; parietal pleura; ; mucosa of paranasal sinus; ; stromal cell of endometrium; ; cartilage tissue; ; epithelium of nasopharynx;
	Top expressed in
	endothelial cell of lymphatic vessel; ; renal corpuscle; ; somite; ; abdominal wall; ; primitive streak; ; maxillary prominence; ; mandibular prominence; ; ventricular zone; ; endocardial cushion; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA binding; cadherin binding;
Cellular component	cytoplasm; membrane;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9689
	66882
	ENSG00000082153
	ENSMUSG00000051223
	Q7L1Q6
	Q9CQC6
NM_001207067; NM_001207068; NM_001207069; NM_014670; NM_001321688;
	NM_001321690; NM_001321691; NM_001321693; NM_001321694
	NM_025824
NP_001193996; NP_001193997; NP_001193998; NP_001308617; NP_001308619;
	NP_001308620; NP_001308622; NP_001308623; NP_055485
	NP_080100
	Wikidata
View/Edit Human	View/Edit Mouse

Basic leucine zipper and W2 domain-containing protein 1 is a protein that in humans is encoded by the BZW1 gene and expressed in the nucleus.^[5]^[6]^[7] It enables RNA and cadherin binding activity.^[8]

Salivary gland carcinoma and eastern equine encephalitis are associated with BZW1.

Interactions

BZW1 has been shown to interact with PSTPIP1^[9] and CDC5L.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082153 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
^ Mitra P, Vaughan PS, Stein JL, Stein GS, van Wijnen AJ (August 2001). "Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription". Biochemistry. 40 (35): 10693–9. doi:10.1021/bi010529o. PMID 11524015.
^ "Entrez Gene: BZW1 basic leucine zipper and W2 domains 1".
^ "BZW1 basic leucine zipper and W2 domains 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-10-20.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

External links

Human BZW1 genome location and BZW1 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082153 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051223 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10964520-5] Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.

[pmid11524015-6] Mitra P, Vaughan PS, Stein JL, Stein GS, van Wijnen AJ (August 2001). "Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription". Biochemistry. 40 (35): 10693–9. doi:10.1021/bi010529o. PMID 11524015.

[entrez-7] "Entrez Gene: BZW1 basic leucine zipper and W2 domains 1".

[8] "BZW1 basic leucine zipper and W2 domains 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-10-20.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid11101529-10] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

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Interactions

References

Further reading

External links