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CD24

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(Redirected from Antigens, cd24)

CD24
Identifiers
AliasesCD24, CD24A, CD24 molecule
External IDsOMIM: 600074; MGI: 88323; GeneCards: CD24; OMA:CD24 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291737
NM_001291738
NM_001291739
NM_013230
NM_001359084

NM_009846

RefSeq (protein)

NP_001278666
NP_001278667
NP_001278668
NP_037362
NP_001346013

NP_033976

Location (UCSC)Chr 6: 106.97 – 106.98 MbChr 10: 43.45 – 43.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.[5] CD24 is a cell adhesion molecule.

Function

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CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils[6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.[7] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,[8] and this appears to be defective in sepsis.[8] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.[citation needed]

Researchers have identified CD24 as a novel cell surface marker that flags anastasis in melanoma cells, a process where cells that have initiated apoptosis can recover and survive.[9] This discovery highlights CD24’s role in marking apoptotic subpopulations that exhibit metabolic activity and proliferative capacities, contributing to melanoma’s resilience and potential metastasis.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000272398Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047139Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.
  6. ^ Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. S2CID 39674808.
  7. ^ Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. S2CID 3492300.
  8. ^ a b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. S2CID 45838206.
  9. ^ Vasileva MH, Bennemann A, Zachmann K, Schön MP, Frank J, Ulaganathan VK (August 2024). "CD24 flags anastasis in melanoma cells". Apoptosis. doi:10.1007/s10495-024-01990-1. PMID 39136818.

Further reading

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