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{{Infobox scientist
{{Notability|biographies|date=June 2010}}
| name = Korkut Uygun
{{Primarysources|date=June 2010}}
⚫
| image =
⚫
'''Korkut Uygun''' is a [[Turkish people|Turkish]] [[Chemical engineering|chemical engineering]] scientist and a [[Medical research scientist|medical researcher]].
| caption = Korkut Uygun
| birth_date = Jan, 1975
| birth_place = [[Bonn]], [[Germany]]
| nationality = [[Turkey|Turkish]]
| field = [[organ transplant|Transplantation]], [[Systems Biology]], [[Biomedical Engineering]]
| work_institution = [[Harvard Medical School]], [[Massachusetts General Hospital]]
| alma_mater = [[Boğaziçi University]], [[Wayne State University]]
⚫
| doctoral_advisor = [http://chem1.eng.wayne.edu/~yhuang/ Yinlun Huang]
| awards = [http://grants.nih.gov/grants/guide/pa-files/PA-11-197.html NIH Pathway to Independence Award], 2008; Massachusetts General Hospital Junior Faculty Award, 2009
| footnotes =
}}


⚫
'''Korkut Uygun''' is a [[Turkish people|Turkish]] [[chemical engineer]] and a [[medical researcher]].
Uygun is married to '''Başak Saygılı Uygun''' who is also a [[Medical research scientist|medical researcher]]. Uygun couple has a daughter called Elif Naz<ref>{{citation
⚫
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
⚫
| title =Lab News of 2010
⚫
| date =2 April 2010
⚫
| publisher =Wayne State University
⚫
| location =U.S.A.
| format =HTML
⚫
| accessdate =15 June 2010
⚫
}}</ref>.


==Career==
⚫
Uygun received his Ph.D. in [[Chemical engineering|chemical engineering]] from [[Wayne State University]] in 2004 <ref>{{citation
Uygun received his BSc and MSc from Boğaziçi University in Istanbul, Turkey, with Dr. Ugur Akman as his advisor on both his MSc and BSc theses.<ref>{{citation
| url =http://web.boun.edu.tr/akman/cv.html#AREF7
| title =Ugur Akman's CV
| date =Jan 2000
⚫
| publisher =Boğaziçi University
| location =Turkey
⚫
| accessdate =13 May 2011
⚫
}}</ref> He received Ph.D. in [[chemical engineering]] from [[Wayne State University]] in 2004.<ref>{{citation
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| title =Lab News of 2004
| title =Lab News of 2004
Line 19: Line 30:
| publisher =Wayne State University
| publisher =Wayne State University
| location =U.S.A.
| location =U.S.A.
| format =HTML
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref>. After working as a post-doctor in the research laboratory of the department that he received his Ph.D. for 2 years, he bacame a research associate in the "Center for Engineering in Medicine" of the [[Massachusetts General Hospital]]<ref>{{citation
}}</ref> After working for 2 years as a post-doctoral researcher in the research laboratory of the department where he received his Ph.D., in 2006 he became a research associate in the lab of Maish Yarmush at the "Center for Engineering in Medicine" of the [[Massachusetts General Hospital]],<ref>{{citation
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| title =Lab News of 2006
| title =Lab News of 2006
Line 27: Line 37:
| publisher =Wayne State University
| publisher =Wayne State University
| location =U.S.A.
| location =U.S.A.
| format =HTML
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref> in 2006. He bacame the leader of the "Organ Engineering Group" in the center. In 2008, he was promoted to "instructor in surgery (Bioengineering)" at [[Harvard Medical School]]<ref>{{citation
}}</ref> where he became the leader of the Organ Engineering Group. In 2008, he was promoted to instructor in surgery (Bioengineering) at [[Harvard Medical School]].<ref name="WayneChemLabNews2008">{{citation
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| title =Lab News of 2008
| title =Lab News of 2008
Line 35: Line 44:
| publisher =Wayne State University
| publisher =Wayne State University
| location =U.S.A.
| location =U.S.A.
| format =HTML
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref> In 2011 he was promoted to Assistant Professor in Surgery at Harvard Medical School, before being promoted to Associate Professor a few years later.<ref>{{citation
}}</ref>.
| url =http://cem.sbi.org/web/news-intro.htm
⚫
| title =CEM News
| date =2 March 2011
| publisher =Center for Engineering in Medicine
⚫
| location =U.S.A.
| accessdate =13 May 2011
⚫
}}</ref>


==Work==
==Work==
⚫
A major research objective of Uygun is to enhance utilization of discarded [[donor organ]]s in order to either increase the supply of [[Organ transplantation|transplantable organ]]s, utilize untransplantable organs as [[cell (biology)|cell]] sources for cell transplantation or [[bioartificial organ]] substitutes, such as bioartificial [[liver]]s, and if the organ proves completely unresuscitatable, utilize them as biocompatible scaffolds for tissue engineering.

⚫
In 2010, a team led by Uygun in the Center for Engineering in Medicine at [[Massachusetts General Hospital]] developed a technique that someday may allow growth of transplantable replacement livers.<ref>{{citation
⚫
Research objective of Uygun is to recondition discarded donor organs in order increase the supply of of transplantable organs, and utilize the unrecoverable organs as cell sources for cell transplantation or in bioartificial organ substitutes (such as bioartificial livers).

⚫
In 2010, a team led by Uygun in the "Center for Engineering in Medicine" at [[Massachusetts General Hospital]] has developed a technique that someday may allow growth of transplantable replacement livers<ref>{{citation
| url =http://www.massgeneral.org/about/pressrelease.aspx?id=1249
| url =http://www.massgeneral.org/about/pressrelease.aspx?id=1249
| title =Mass. General researchers develop functional, transplantable rat liver grafts
| title =Mass. General researchers develop functional, transplantable rat liver grafts
Line 49: Line 62:
| publisher =Massachusetts General Hospital - News Releases
| publisher =Massachusetts General Hospital - News Releases
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref>. Uygun's technique developed functional, transplantable rat liver grafts<ref>{{citation
}}</ref> Uygun's technique developed functional, transplantable rat liver grafts.<ref>{{citation
| url =http://esciencenews.com/articles/2010/06/13/mass.general.researchers.develop.functional.transplantable.rat.liver.grafts
| url =http://esciencenews.com/articles/2010/06/13/mass.general.researchers.develop.functional.transplantable.rat.liver.grafts
| title =Mass. General researchers develop functional, transplantable rat liver grafts
| title =Mass. General researchers develop functional, transplantable rat liver grafts
Line 55: Line 68:
| publisher =e! Science News
| publisher =e! Science News
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref>. The study was published in [[Nature Medicine]]<ref>Basak E Uygun, Alejandro Soto-Gutierrez, Hiroshi Yagi, Maria-Louisa Izamis, Maria A Guzzardi, Carley Shulman, Jack Milwid, Naoya Kobayashi, Arno Tilles, Francois Berthiaume, Martin Hertl, Yaakov Nahmias, Martin L Yarmush, Korkut Uygun. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. [http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.2170.html Nature Medicine], 2010; DOI: 10.1038/nm.2170</ref>. Uygun highlighted the significance of his work by saying "As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before"<ref>{{citation
}}</ref> The study was published in ''[[Nature Medicine]]''.<ref>Basak E Uygun, Alejandro Soto-Gutierrez, Hiroshi Yagi, Maria-Louisa Izamis, Maria A Guzzardi, Carley Shulman, Jack Milwid, Naoya Kobayashi, Arno Tilles, Francois Berthiaume, Martin Hertl, [[Yaakov Nahmias]], Martin L Yarmush, Korkut Uygun. [http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.2170.html "Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix"]. ''Nature Medicine'', 2010; {{doi|10.1038/nm.2170}}</ref> Uygun highlighted the significance of his work by saying, "As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before".<ref>{{citation
| url =http://www.sciencedaily.com/releases/2010/06/100613181240.htm
| url =https://www.sciencedaily.com/releases/2010/06/100613181240.htm
| title =Functional, Transplantable Rat Liver Grafts: Discarded Livers Have Potential to Be Reengineered Into Usable Replacement Organs
| title =Functional, Transplantable Rat Liver Grafts: Discarded Livers Have Potential to Be Reengineered Into Usable Replacement Organs
| date =15 June 2010
| date =15 June 2010
| publisher =ScienceDaily
| publisher =ScienceDaily
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref>. A novel technique was also used to "reintroduce hepatocytes, the cells that carry out most of the liver’’s primary functions, into the decellularized matrix"<ref>{{citation
}}</ref> A novel technique was also used to "reintroduce hepatocytes, the cells that carry out most of the liver’’s primary functions, into the decellularized matrix".<ref>{{citation
| url =http://infoway.co.in/tag/structure-of-the-heart?wscr=1680x1050
|url = http://infoway.co.in/tag/structure-of-the-heart?wscr=1680x1050
| title =Advance made towards development of transplantable replacement livers
|title = Advance made towards development of transplantable replacement livers
| date =14 June 2010
|date = 14 June 2010
| publisher =Infoway
|publisher = Infoway
| accessdate =15 June 2010
|accessdate = 15 June 2010
|archive-url = https://web.archive.org/web/20110721154654/http://infoway.co.in/tag/structure-of-the-heart?wscr=1680x1050
⚫
}}</ref>. The study was reported as "the first steps in growing working livers"<ref>{{cite news
|archive-date = 21 July 2011
|url-status = dead
⚫
}}</ref> The study was reported as "the first steps in growing working livers".<ref>{{cite news
|url=http://news.bbc.co.uk/2/hi/health/10293842.stm
|url=http://news.bbc.co.uk/2/hi/health/10293842.stm
|title=Scientists take first steps in growing working livers
|title=Scientists take first steps in growing working livers
Line 73: Line 89:
|date=13 June 2010
|date=13 June 2010
|accessdate=15 June 2010
|accessdate=15 June 2010
}}</ref> It is also the basis of a [http://www.wipo.int/pctdb/en/wo.jsp?WO=2011002926 patent application].
}}</ref>.


==Awards==
==Research Awards==
In 2008, Uygun was awarded a Career Award by NIDDK at NIH "Computer-Aided Development of a Liver Organ Culture System".<ref name="WayneChemLabNews2008"/>


In 2008, Uygun was awarded an NIH K99/R00 - Pathway to Independence Award: "Computer-Aided Development of a Liver Organ Culture System"<ref>{{citation
In 2009, Uygun was awarded by the [[National Science Foundation]] for a research project, "Liver Reengineering".<ref>{{citation
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| title =Lab News of 2008
| title =Lab News of 2009
| date =28 April 2008
| date =1 September 2009
| publisher =Wayne State University
| publisher =Wayne State University
| location =U.S.A.
| location =U.S.A.
| format =HTML
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref> which has funded the studies for whole organ decellularization and recellularization.
}}</ref>.


Uygun is also a Co-investigator and collaborator on several projects with [[Martin Yarmush]] and [[Mehmet Toner]]
In 2009, Uygun was awarded by the [[National Science Foundation]] for a very challenging research project, "Liver Reengineering"<ref>{{citation

==Personal life==
Uygun is married to '''Başak E. Saygılı''', who is also a medical researcher and faculty at [http://hms.harvard.edu/WhitePagesPublic.asp?task=showperson&id=ElQxaWNAPDM=&a=hms&r=2&kw= Harvard Medical School] and [http://cem.sbi.org/web/about-people-faculty.htm Center for Engineering in Medicine]; the couple has a daughter called Elif Naz.<ref>{{citation
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| url =http://chem1.eng.wayne.edu/~yhuang/labnews.htm
| title =Lab News of 2009
| title =Lab News of 2010
| date =1 September 2009
| date =2 April 2010
| publisher =Wayne State University
| publisher =Wayne State University
| location =U.S.A.
| location =U.S.A.
| format =HTML
| accessdate =15 June 2010
| accessdate =15 June 2010
}}</ref>.
}}</ref>


==References==
==References==
{{Reflist}}
{{Reflist}}

== External links ==
* [http://cem.sbi.org/web/index.htm Center for Engineering in Medicine Center for Engineering in Medicine]
* [https://www.ncbi.nlm.nih.gov/pubmed?term=korkut%20Uygun list of publications (PubMed)]

{{authority control}}

{{DEFAULTSORT:Uygun, Korkut}}
[[Category:1975 births]]
[[Category:Living people]]
[[Category:Wayne State University alumni]]
[[Category:21st-century Turkish scientists]]
[[Category:Turkish medical researchers]]
[[Category:Turkish chemical engineers]]
[[Category:Turkish biochemists]]
[[Category:Turkish bioengineers]]
[[Category:Harvard Medical School faculty]]

Latest revision as of 17:57, 24 August 2024

Korkut Uygun
BornJan, 1975
Bonn, Germany
NationalityTurkish
Alma materBoğaziçi University, Wayne State University
AwardsNIH Pathway to Independence Award, 2008; Massachusetts General Hospital Junior Faculty Award, 2009
Scientific career
FieldsTransplantation, Systems Biology, Biomedical Engineering
InstitutionsHarvard Medical School, Massachusetts General Hospital
Doctoral advisorYinlun Huang

Korkut Uygun is a Turkish chemical engineer and a medical researcher.

Career

[edit]

Uygun received his BSc and MSc from Boğaziçi University in Istanbul, Turkey, with Dr. Ugur Akman as his advisor on both his MSc and BSc theses.[1] He received Ph.D. in chemical engineering from Wayne State University in 2004.[2] After working for 2 years as a post-doctoral researcher in the research laboratory of the department where he received his Ph.D., in 2006 he became a research associate in the lab of Maish Yarmush at the "Center for Engineering in Medicine" of the Massachusetts General Hospital,[3] where he became the leader of the Organ Engineering Group. In 2008, he was promoted to instructor in surgery (Bioengineering) at Harvard Medical School.[4] In 2011 he was promoted to Assistant Professor in Surgery at Harvard Medical School, before being promoted to Associate Professor a few years later.[5]

Work

[edit]

A major research objective of Uygun is to enhance utilization of discarded donor organs in order to either increase the supply of transplantable organs, utilize untransplantable organs as cell sources for cell transplantation or bioartificial organ substitutes, such as bioartificial livers, and if the organ proves completely unresuscitatable, utilize them as biocompatible scaffolds for tissue engineering. In 2010, a team led by Uygun in the Center for Engineering in Medicine at Massachusetts General Hospital developed a technique that someday may allow growth of transplantable replacement livers.[6] Uygun's technique developed functional, transplantable rat liver grafts.[7] The study was published in Nature Medicine.[8] Uygun highlighted the significance of his work by saying, "As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before".[9] A novel technique was also used to "reintroduce hepatocytes, the cells that carry out most of the liver’’s primary functions, into the decellularized matrix".[10] The study was reported as "the first steps in growing working livers".[11] It is also the basis of a patent application.

Research Awards

[edit]

In 2008, Uygun was awarded a Career Award by NIDDK at NIH "Computer-Aided Development of a Liver Organ Culture System".[4]

In 2009, Uygun was awarded by the National Science Foundation for a research project, "Liver Reengineering".[12] which has funded the studies for whole organ decellularization and recellularization.

Uygun is also a Co-investigator and collaborator on several projects with Martin Yarmush and Mehmet Toner

Personal life

[edit]

Uygun is married to Başak E. Saygılı, who is also a medical researcher and faculty at Harvard Medical School and Center for Engineering in Medicine; the couple has a daughter called Elif Naz.[13]

References

[edit]
  1. ^ Ugur Akman's CV, Turkey: Boğaziçi University, Jan 2000, retrieved 13 May 2011
  2. ^ Lab News of 2004, U.S.A.: Wayne State University, 24 June 2004, retrieved 15 June 2010
  3. ^ Lab News of 2006, U.S.A.: Wayne State University, 7 July 2006, retrieved 15 June 2010
  4. ^ a b Lab News of 2008, U.S.A.: Wayne State University, 28 April 2008, retrieved 15 June 2010
  5. ^ CEM News, U.S.A.: Center for Engineering in Medicine, 2 March 2011, retrieved 13 May 2011
  6. ^ Mass. General researchers develop functional, transplantable rat liver grafts, Massachusetts General Hospital - News Releases, 13 June 2010, retrieved 15 June 2010
  7. ^ Mass. General researchers develop functional, transplantable rat liver grafts, e! Science News, 13 June 2010, retrieved 15 June 2010
  8. ^ Basak E Uygun, Alejandro Soto-Gutierrez, Hiroshi Yagi, Maria-Louisa Izamis, Maria A Guzzardi, Carley Shulman, Jack Milwid, Naoya Kobayashi, Arno Tilles, Francois Berthiaume, Martin Hertl, Yaakov Nahmias, Martin L Yarmush, Korkut Uygun. "Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix". Nature Medicine, 2010; doi:10.1038/nm.2170
  9. ^ Functional, Transplantable Rat Liver Grafts: Discarded Livers Have Potential to Be Reengineered Into Usable Replacement Organs, ScienceDaily, 15 June 2010, retrieved 15 June 2010
  10. ^ Advance made towards development of transplantable replacement livers, Infoway, 14 June 2010, archived from the original on 21 July 2011, retrieved 15 June 2010
  11. ^ "Scientists take first steps in growing working livers". BBC News. 13 June 2010. Retrieved 15 June 2010.
  12. ^ Lab News of 2009, U.S.A.: Wayne State University, 1 September 2009, retrieved 15 June 2010
  13. ^ Lab News of 2010, U.S.A.: Wayne State University, 2 April 2010, retrieved 15 June 2010
[edit]
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